• 3154 Citations
  • 34 h-Index
1981 …2019

Research output per year

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Research Output

2019

Analysis of HIV-1 matrix-envelope cytoplasmic tail interactions

Alfadhli, A., Staubus, A. O., Tedbury, P. R., Novikova, M., Freed, E. O. & Barklis, E., Jan 1 2019, In : Journal of virology. 93, 21, e01079-19.

Research output: Contribution to journalArticle

5 Scopus citations

Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes

Barklis, E., Stephen, A. G., Staubus, A. O., Barklis, R. L. & Alfadhli, A., Sep 6 2019, In : Journal of molecular biology. 431, 19, p. 3706-3717 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Replication of HIV-1 envelope protein cytoplasmic domain variants in permissive and restrictive cells

Staubus, A. O., Alfadhli, A., Barklis, R. L. & Barklis, E., Dec 2019, In : Virology. 538, p. 1-10 10 p.

Research output: Contribution to journalArticle

2018

Lipid biosensor interactions with wild type and matrix deletion HIV-1 Gag proteins

Barklis, E., Staubus, A. O., Mack, A., Harper, L., Barklis, R. L. & Alfadhli, A., May 1 2018, In : Virology. 518, p. 264-271 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Analysis of K-Ras interactions by biotin ligase tagging

Ritchie, C., Mack, A., Harper, L., Alfadhli, A., Stork, P. J. S., Nan, X. & Barklis, E., Jul 1 2017, In : Cancer Genomics and Proteomics. 14, 4, p. 225-239 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties

Alfadhli, A., Mack, A., Harper, L., Berk, S., Ritchie, C. & Barklis, E., Nov 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5618-5625 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Trimer enhancement mutation effects on HIV-1 matrix protein binding activities

Alfadhli, A., Mack, A., Ritchie, C., Cylinder, I., Harper, L., Tedbury, P. R., Freed, E. O. & Barklis, E., Jun 1 2016, In : Journal of virology. 90, 12, p. 5657-5664 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Analysis of HIV-1 gag protein interactions via biotin ligase tagging

Ritchie, C., Cylinder, I., Platt, E. J. & Barklis, E., 2015, In : Journal of virology. 89, 7, p. 3988-4001 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

RRE-dependent HIV-1 Env RNA effects on Gag protein expression, assembly and release

López, C. S., Sloan, R., Cylinder, I., Kozak, S. L., Kabat, D. & Barklis, E., Aug 2014, In : Virology. 462-463, 1, p. 126-134 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

The roles of lipids and nucleic acids in HIV-1 assembly

Alfadhli, A. & Barklis, E., 2014, In : Frontiers in Microbiology. 5, MAY, 253.

Research output: Contribution to journalReview article

18 Scopus citations
2013

Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site

Alfadhli, A., McNett, H., Eccles, J., Tsagli, S., Noviello, C., Sloan, R., López, C. S., Peyton, D. H. & Barklis, E., Jan 4 2013, In : Journal of Biological Chemistry. 288, 1, p. 666-676 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Second site reversion of a mutation near the amino terminus of the HIV-1 capsid protein

López, C. S., Tsagli, S. M., Sloan, R., Eccles, J. & Barklis, E., Dec 1 2013, In : Virology. 447, 1-2, p. 95-103 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Virus assembly as a target for antiretroviral therapy

Barklis, E., Apr 1 2013, Advances in HIV-1 Assembly and Release. Springer New York, p. 185-214 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Sultam thioureas: Synthesis and antiviral activity against west nile virus

Feeny, R. M., Le, D. N., Parks, J. W., Epstein, M. G., Pagano, J. V., Abbene, A. C., Graham, E. B., Farrell, J. R., McGuire, J. R., Zoellner, R. W., Valente, E. J., Barklis, E. & Wood, W. J. L., Jan 1 2012, In : Synlett. 2, p. 301-305 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2011

Analysis of the N-terminal region of the murine leukemia virus nucleocapsid protein

Still, A., Huseby, D. & Barklis, E., Jan 1 2011, In : Virus Research. 155, 1, p. 181-188 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Determinants of the HIV-1 core assembly pathway

López, C. S., Eccles, J. D., Still, A., Sloan, R. E., Barklis, R. L., Tsagli, S. M. & Barklis, E., Aug 15 2011, In : Virology. 417, 1, p. 137-146 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

HIV-1 matrix protein binding to RNA

Alfadhli, A., McNett, H., Tsagli, S., Bächinger, H. P., Peyton, D. H. & Barklis, E., Jul 22 2011, In : Journal of molecular biology. 410, 4, p. 653-666 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Second-site compensatory mutations of HIV-1 capsid mutations

Noviello, C. M., López, C. S., Kukull, B., McNett, H., Still, A., Eccles, J., Sloan, R. & Barklis, E., May 2011, In : Journal of virology. 85, 10, p. 4730-4738 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2010

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

Dikeakos, J. D., Atkins, K. M., Thomas, L., Emert-Sedlak, L., Byeon, I. J. L., Jung, J., Ahn, J., Wortman, M. D., Kukull, B., Saito, M., Koizumi, H., Williamson, D. M., Hiyoshi, M., Barklis, E., Takiguchi, M., Suzu, S., Gronenborn, A. M., Smithgall, T. E. & Thomas, G., Oct 1 2010, In : Molecular biology of the cell. 21, 19, p. 3279-3292 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis

Zeng, S. X., Li, Y., Jin, Y., Zhang, Q., Keller, D. M., McQuaw, C. M., Barklis, E., Stone, S., Hoatlin, M., Zhao, Y. & Lu, H., Feb 1 2010, In : Molecular and cellular biology. 30, 4, p. 935-947 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
2009

Analysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids

Alfadhli, A., Still, A. & Barklis, E., Dec 1 2009, In : Journal of virology. 83, 23, p. 12196-12203 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

Characterization of the In Vitro HIV-1 Capsid Assembly Pathway

Barklis, E., Alfadhli, A., McQuaw, C., Yalamuri, S., Still, A., Barklis, R. L., Kukull, B. & López, C. S., Mar 27 2009, In : Journal of molecular biology. 387, 2, p. 376-389 14 p.

Research output: Contribution to journalArticle

38 Scopus citations

HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate

Alfadhli, A., Barklis, R. L. & Barklis, E., May 10 2009, In : Virology. 387, 2, p. 466-472 7 p.

Research output: Contribution to journalArticle

70 Scopus citations
2008

Analysis of human immunodeficiency virus matrix domain replacements

Scholz, I., Still, A., Dhenub, T. C., Coday, K., Webb, M. & Barklis, E., Feb 20 2008, In : Virology. 371, 2, p. 322-335 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
2007

HIV-1 Nef Assembles a Src Family Kinase-ZAP-70/Syk-PI3K Cascade to Downregulate Cell-Surface MHC-I

Hung, C. H., Thomas, L., Ruby, C. E., Atkins, K. M., Morris, N. P., Knight, Z. A., Scholz, I., Barklis, E., Weinberg, A. D., Shokat, K. M. & Thomas, G., Apr 19 2007, In : Cell Host and Microbe. 1, 2, p. 121-133 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Human immunodeficiency virus type 1 matrix protein assembles on membranes as a hexamer

Alfadhli, A., Huseby, D., Kapit, E., Colman, D. & Barklis, E., Feb 2007, In : Journal of virology. 81, 3, p. 1472-1478 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Sultam thiourea inhibition of West Nile virus

Barklis, E., Still, A., Sabri, M. I., Hirsch, A. J., Nikolich-Zugich, J., Brien, J., Dhenub, T. C., Scholz, I. & Alfadhli, A., Jul 2007, In : Antimicrobial agents and chemotherapy. 51, 7, p. 2642-2645 4 p.

Research output: Contribution to journalArticle

11 Scopus citations
2005

Analysis of human immunodeficiency virus type 1 Gag dimerization-induced assembly

Alfadhli, A., Dhenub, T. C., Still, A. & Barklis, E., Dec 2005, In : Journal of virology. 79, 23, p. 14498-14506 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication

Vana, M. L., Chen, A., Boross, P., Weber, I., Colman, D., Barklis, E. & Leis, J., Sep 27 2005, In : Retrovirology. 2, 58.

Research output: Contribution to journalArticle

1 Scopus citations

Virus particle core defects caused by mutations in the human immunodeficiency virus capsid N-terminal domain

Scholz, I., Arvidson, B., Huseby, D. & Barklis, E., Feb 1 2005, In : Journal of virology. 79, 3, p. 1470-1479 10 p.

Research output: Contribution to journalArticle

44 Scopus citations
2003

Analysis of the retrovirus capsid interdomain linker region

Arvidson, B., Seeds, J., Webb, M., Finlay, L. & Barklis, E., Mar 30 2003, In : Virology. 308, 1, p. 166-177 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Antiviral Inhibition of the HIV-1 capsid protein

Tang, C., Loeliger, E., Kinde, I., Kyere, S., Mayo, K., Barklis, E., Sun, Y., Huang, M. & Summers, M. F., Apr 11 2003, In : Journal of molecular biology. 327, 5, p. 1013-1020 8 p.

Research output: Contribution to journalArticle

159 Scopus citations

Retrovirus capsid protein assembly arrangements

Mayo, K., Huseby, D., McDermott, J., Arvidson, B., Finlay, L. & Barklis, E., Jan 1 2003, In : Journal of molecular biology. 325, 1, p. 225-237 13 p.

Research output: Contribution to journalArticle

63 Scopus citations
2002

Analysis of Rous sarcoma virus capsid protein variants assembled on lipid monolayers

Mayo, K., Vana, M. L., McDermott, J., Huseby, D., Leis, J. & Barklis, E., Jan 1 2002, In : Journal of molecular biology. 316, 3, p. 667-678 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

EMXtalOrg: An EM tilt data organization and processing system

McDermott, J. & Barklis, E., Oct 1 2002, In : Ultramicroscopy. 93, 1, p. 11-17 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Hantavirus nucleocapsid protein coiled-coil domains

Alfadhli, A., Steel, E., Finlay, L., Bächinger, H. P. & Barklis, E., Jul 26 2002, In : Journal of Biological Chemistry. 277, 30, p. 27103-27108 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Hexagonal organization of Moloney murine leukemia virus capsid proteins

Mayo, K., McDermott, J. & Barklis, E., Jan 1 2002, In : Virology. 298, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2001

Chemistry and discharge characteristics of Odukpani junction springs, Calabar Flank, south-eastern Nigeria

Zuber, G. & Barklis, E., Jan 1 2001, In : Environmental Geology. 40, 10, p. 1214-1223 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Hantavirus nucleocapsid protein oligomerization

Alfadhli, A., Love, Z., Arvidson, B., Seeds, J., Willey, J. & Barklis, E., 2001, In : Journal of virology. 75, 4, p. 2019-2023 5 p.

Research output: Contribution to journalArticle

70 Scopus citations
2000

Assembly of retrovirus capsid-nucleocapsid proteins in the presence of membranes or RNA

Zuber, G., McDermott, J., Karanjia, S., Zhao, W., Schmid, M. F. & Barklis, E., 2000, In : Journal of virology. 74, 16, p. 7431-7441 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Atomic force microscopy and electron microscopy analysis of retrovirus Gag proteins assembled in vitro on lipid bilayers

Zuber, G. & Barklis, E., Jan 1 2000, In : Biophysical Journal. 78, 1, p. 373-384 12 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Crosslink analysis of N-terminal, C-terminal, and N/B determining regions of the Moloney murine leukemia virus capsid protein

McDermott, J., Karanjia, S., Love, Z. & Barklis, E., Mar 30 2000, In : Virology. 269, 1, p. 190-200 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Three-dimensional organization of retroviral capsid proteins on a lipid monolayer

McDermott, J., Mayo, K. & Barklis, E., Sep 8 2000, In : Journal of molecular biology. 302, 1, p. 121-133 13 p.

Research output: Contribution to journalArticle

20 Scopus citations
1998

Analysis of the assembly function of the human immunodeficiency virus type 1 gag protein nucleocapsid domain

Zhang, Y., Qian, H., Love, Z. & Barklis, E., Mar 1998, In : Journal of virology. 72, 3, p. 1782-1789 8 p.

Research output: Contribution to journalArticle

Open Access
174 Scopus citations

Organization of HIV-1 capsid proteins on a lipid monolayer

Barklis, E., McDermott, J., Wilkens, S., Fuller, S. & Thompson, D., Mar 27 1998, In : Journal of Biological Chemistry. 273, 13, p. 7177-7180 4 p.

Research output: Contribution to journalArticle

55 Scopus citations
9 Scopus citations
1997

A role for two hairpin structures as a core RNA encapsidation signal in murine leukemia virus virions

Mougel, M. & Barklis, E., 1997, In : Journal of virology. 71, 10, p. 8061-8065 5 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Effects of nucleocapsid mutations on human immunodeficiency virus assembly and RNA encapsidation

Zhang, Y. & Barklis, E., Jan 1 1997, In : Journal of virology. 71, 9, p. 6765-6776 12 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations
2 Scopus citations