Alec Hirsch

Assistant Professor

  • 949 Citations
  • 16 h-Index
19942019
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  • 3 Similar Profiles
West Nile virus Medicine & Life Sciences
Dengue Virus Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
Dengue virus Agriculture & Biology
Virus Replication Medicine & Life Sciences
Flavivirus Medicine & Life Sciences
Macaca mulatta Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences

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Projects 2012 2015

Flavivirus
MicroRNAs
Japanese Encephalitis Virus
West Nile virus
Therapeutics

Research Output 1994 2019

  • 949 Citations
  • 16 h-Index
  • 23 Article
  • 2 Comment/debate
  • 1 Chapter

Dengue virus replication inhibition by dibenzothiepin derivatives

Mihai, D. P., Nitulescu, G. M., Smith, J. L., Hirsch, A. & Stecoza, C. E., Jan 1 2019, (Accepted/In press) In : Medicinal Chemistry Research.

Research output: Contribution to journalArticle

Dibenzothiepins
Thiepins
Dengue Virus
Virus Replication
Viruses
2 Citations (Scopus)

Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions

Smith, J. L., Sheridan, K., Parkins, C. J., Frueh, L., Jemison, A. L., Strode, K., Dow, G., Nilsen, A. & Hirsch, A., Jul 1 2018, In : Antiviral Research. 155, p. 12-19 8 p.

Research output: Contribution to journalArticle

Dengue Virus
Capsid Proteins
Structure-Activity Relationship
Virion
Antiviral Agents
11 Citations (Scopus)

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Dudley, D. M., Van Rompay, K. K., Coffey, L. L., Ardeshir, A., Keesler, R. I., Bliss-Moreau, E., Grigsby, P., Steinbach, R. J., Hirsch, A., MacAllister, R., Pecoraro, H. L., Colgin, L., Hodge, T., Streblow, D., Tardif, S., Patterson, J. L., Tamhankar, M., Seferovic, M., Aagaard, K. M., Martín, C. S. S. & 18 others, Chiu, C. Y., Panganiban, A. T., Veazey, R. S., Wang, X., Maness, N. J., Gilbert, M. H., Bohm, R. P., Adams Waldorf, K. M., Gale, M., Rajagopal, L., Hotchkiss, C. E., Mohr, E. L., Capuano, S. V., Simmons, H. A., Mejia, A., Friedrich, T. C., Golos, T. G. & O’Connor, D. H., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1104-1107 4 p.

Research output: Contribution to journalArticle

Stillbirth
Spontaneous Abortion
Viruses
Primates
Mothers
26 Citations (Scopus)

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Hirsch, A., Roberts, V., Grigsby, P., Haese, N., Schabel, M., Wang, X., Lo, J., Liu, Z., Kroenke, C. C., Smith, J. L., Kelleher, M., Broeckel, R., Kreklywich, C. N., Parkins, C. J., Denton, M., Smith, P., De Filippis, V., Messer, W., Nelson, J., Hennebold, J. & 12 others, Grafe, M., Colgin, L., Lewis, A., Ducore, R., Swanson, T., Legasse, A. W., Axthelm, M., MacAllister, R., Moses, A., Morgan, T., Frias, A. & Streblow, D., Dec 1 2018, In : Nature Communications. 9, 1, 263.

Research output: Contribution to journalArticle

viruses
infectious diseases
Fetal Development
Macaca mulatta
Viruses
29 Citations (Scopus)

A microRNA screen identifies the Wnt signaling pathway as a regulator of the interferon response during flavivirus infection

Smith, J. L., Jeng, S., McWeeney, S. & Hirsch, A., Apr 1 2017, In : Journal of Virology. 91, 8, e02388-16.

Research output: Contribution to journalArticle

Flavivirus Infections
Flavivirus
Wnt Signaling Pathway
interferons
MicroRNAs