Alec Hirsch

Assistant Professor

  • 1129 Citations
  • 18 h-Index
1994 …2020

Research output per year

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Research Output

  • 1129 Citations
  • 18 h-Index
  • 24 Article
  • 2 Comment/debate
  • 1 Chapter
  • 1 Review article
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Article
2020

The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection

Murphy Schafer, A. R., Smith, J. L., Pryke, K. M., DeFilippis, V. R. & Hirsch, A. J., Feb 14 2020, In : Frontiers in Microbiology. 11, 24.

Research output: Contribution to journalArticle

Open Access
2019

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

Kim, C., Jadhav, R. R., Gustafson, C. E., Smithey, M. J., Hirsch, A. J., Uhrlaub, J. L., Hildebrand, W. H., Nikolich-Žugich, J., Weyand, C. M. & Goronzy, J. J., Nov 19 2019, In : Cell Reports. 29, 8, p. 2202-2216.e5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Dengue virus replication inhibition by dibenzothiepin derivatives

Mihai, D. P., Nitulescu, G. M., Smith, J. L., Hirsch, A. & Stecoza, C. E., Jan 1 2019, (Accepted/In press) In : Medicinal Chemistry Research.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions

Smith, J. L., Sheridan, K., Parkins, C. J., Frueh, L., Jemison, A. L., Strode, K., Dow, G., Nilsen, A. & Hirsch, A., Jul 1 2018, In : Antiviral Research. 155, p. 12-19 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Dudley, D. M., Van Rompay, K. K., Coffey, L. L., Ardeshir, A., Keesler, R. I., Bliss-Moreau, E., Grigsby, P. L., Steinbach, R. J., Hirsch, A. J., MacAllister, R. P., Pecoraro, H. L., Colgin, L. M., Hodge, T., Streblow, D. N., Tardif, S., Patterson, J. L., Tamhankar, M., Seferovic, M., Aagaard, K. M., Martín, C. S. S. & 18 others, Chiu, C. Y., Panganiban, A. T., Veazey, R. S., Wang, X., Maness, N. J., Gilbert, M. H., Bohm, R. P., Adams Waldorf, K. M., Gale, M., Rajagopal, L., Hotchkiss, C. E., Mohr, E. L., Capuano, S. V., Simmons, H. A., Mejia, A., Friedrich, T. C., Golos, T. G. & O’Connor, D. H., Aug 1 2018, In : Nature medicine. 24, 8, p. 1104-1107 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Hirsch, A. J., Roberts, V. H. J., Grigsby, P. L., Haese, N., Schabel, M. C., Wang, X., Lo, J. O., Liu, Z., Kroenke, C. D., Smith, J. L., Kelleher, M., Broeckel, R., Kreklywich, C. N., Parkins, C. J., Denton, M., Smith, P., Defilippis, V., Messer, W., Nelson, J. A., Hennebold, J. D. & 12 others, Grafe, M., Colgin, L., Lewis, A., Ducore, R., Swanson, T., Legasse, A. W., Axthelm, M. K., MacAllister, R., Moses, A. V., Morgan, T. K., Frias, A. E. & Streblow, D. N., Dec 1 2018, In : Nature Communications. 9, 1, 263.

Research output: Contribution to journalArticle

61 Scopus citations
2017

A microRNA screen identifies the Wnt signaling pathway as a regulator of the interferon response during flavivirus infection

Smith, J. L., Jeng, S., McWeeney, S. & Hirsch, A., Apr 1 2017, In : Journal of Virology. 91, 8, e02388-16.

Research output: Contribution to journalArticle

49 Scopus citations

A novel agonist of the trif pathway induces a cellular state refractory to replication of Zika, Chikungunya, and dengue viruses

Pryke, K. M., Abraham, J., Sali, T. M., Gall, B. J., Archer, I., Liu, A., Bambina, S., Baird, J., Gough, M., Chakhtoura, M., Haddad, E. K., Kirby, I. T., Nilsen, A., Streblow, D. N., Hirsch, A. J., Smith, J. L. & Defilippis, V. R., May 1 2017, In : mBio. 8, 3, e00452-17.

Research output: Contribution to journalArticle

20 Scopus citations

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Hirsch, A. J., Smith, J. L., Haese, N. N., Broeckel, R. M., Parkins, C. J., Kreklywich, C., DeFilippis, V. R., Denton, M., Smith, P. P., Messer, W. B., Colgin, L. M. A., Ducore, R. M., Grigsby, P. L., Hennebold, J. D., Swanson, T., Legasse, A. W., Axthelm, M. K., MacAllister, R., Wiley, C. A., Nelson, J. A. & 1 others, Streblow, D. N., Mar 2017, In : PLoS pathogens. 13, 3, e1006219.

Research output: Contribution to journalArticle

124 Scopus citations
2014

Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling

Smith, J. L., Stein, D. A., Shum, D., Fischer, M. A., Radu, C., Bhinder, B., Djaballah, H., Nelson, J. A., Früh, K. & Hirsch, A. J., 2014, In : Journal of virology. 88, 10, p. 5533-5542 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2013

Flaviviruses are sensitive to inhibition of thymidine synthesis pathways

Fischer, M. A., Smith, J. L., Shum, D., Stein, D. A., Parkins, C., Bhinder, B., Radu, C., Hirsch, A. J., Djaballah, H., Nelson, J. A. & Früh, K., 2013, In : Journal of virology. 87, 17, p. 9411-9419 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Induction of the cellular microRNA, Hs_154, by west nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors

Smith, J. L., Grey, F. E., Uhrlaub, J. L., Nikolich-Zugich, J. & Hirsch, A. J., May 2012, In : Journal of virology. 86, 9, p. 5278-5287 10 p.

Research output: Contribution to journalArticle

46 Scopus citations
2011

Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence

Stein, D. A., Perry, S. T., Buck, M. D., Oehmen, C. S., Fischer, M. A., Poore, E., Smith, J. L., Lancaster, A. M., Hirsch, A. J., Slifka, M. K., Nelson, J. A., Shresta, S. & Früh, K., Oct 1 2011, In : Journal of virology. 85, 19, p. 10154-10166 13 p.

Research output: Contribution to journalArticle

36 Scopus citations
2010

High-content assay to identify inhibitors of dengue virus infection

Shum, D., Smith, J. L., Hirsch, A. J., Bhinder, B., Radu, C., Stein, D. A., Nelson, J. A., Früh, K. & Djaballah, H., Oct 1 2010, In : Assay and Drug Development Technologies. 8, 5, p. 553-570 18 p.

Research output: Contribution to journalArticle

56 Scopus citations

Immune response to the West Nile virus in aged non- human primates

Wertheimer, A. M., Uhrlaub, J. L., Hirsch, A., Medigeshi, G., Sprague, J., Legasse, A., Wilk, J., Wiley, C. A., Didier, P., Tesh, R. B., Murray, K. O., Axthelm, M. K., Wong, S. W. & Nikolich-Žugich, J., 2010, In : PloS one. 5, 12, e15514.

Research output: Contribution to journalArticle

16 Scopus citations
2009

Key role of T cell defects in age-related vulnerability to West Nile virus

Brien, J. D., Uhrlaub, J. L., Hirsch, A., Wiley, C. A. & Nikolich-Žugich, J., Nov 23 2009, In : Journal of Experimental Medicine. 206, 12, p. 2735-2745 11 p.

Research output: Contribution to journalArticle

93 Scopus citations

West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function

Medigeshi, G. R., Hirsch, A. J., Brien, J. D., Uhrlaub, J. L., Mason, P. W., Wiley, C., Nikolich-Zugich, J. & Nelson, J. A., Jun 1 2009, In : Journal of virology. 83, 12, p. 6125-6134 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
2008

West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of αvβ3 integrin

Medigeshi, G. R., Hirsch, A. J., Streblow, D. N., Nikolich-Zugich, J. & Nelson, J. A., Jun 1 2008, In : Journal of virology. 82, 11, p. 5212-5219 8 p.

Research output: Contribution to journalArticle

97 Scopus citations
2007

Sultam thiourea inhibition of West Nile virus

Barklis, E., Still, A., Sabri, M. I., Hirsch, A. J., Nikolich-Zugich, J., Brien, J., Dhenub, T. C., Scholz, I. & Alfadhli, A., Jul 2007, In : Antimicrobial agents and chemotherapy. 51, 7, p. 2642-2645 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis

Medigeshi, G. R., Lancaster, A. M., Hirsch, A. J., Briese, T., Lipkin, W. I., DeFilippis, V., Früh, K., Mason, P. W., Nikolich-Zugich, J. & Nelson, J. A., Oct 2007, In : Journal of virology. 81, 20, p. 10849-10860 12 p.

Research output: Contribution to journalArticle

149 Scopus citations
2005

The Src family kinase c-Yes is required for maturation of West Nile virus particles

Hirsch, A. J., Medigeshi, G. R., Meyers, H. L., DeFilippis, V., Früh, K., Briese, T., Lipkin, W. I. & Nelson, J. A., Sep 2005, In : Journal of virology. 79, 18, p. 11943-11951 9 p.

Research output: Contribution to journalArticle

62 Scopus citations
2004

Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Gα12

Melnychuk, R. M., Streblow, D. N., Smith, P. P., Hirsch, A. J., Pancheva, D. & Nelson, J. A., Aug 1 2004, In : Journal of virology. 78, 15, p. 8382-8391 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
1999

Human cytomegalovirus inhibits transcription of the CC chemokine MCP-1 gene

Hirsch, A. J. & Shenk, T., 1999, In : Journal of virology. 73, 1, p. 404-410 7 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations
1994

A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis

Armand, P., Knapp, A. C., Hirsch, A. J., Wieschaus, E. F. & Cole, M. D., Jun 1994, In : Molecular and cellular biology. 14, 6, p. 4145-4154 10 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations