Alec Hirsch

Assistant Professor

  • 984 Citations
  • 17 h-Index
19942019
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Research Output 1994 2019

  • 984 Citations
  • 17 h-Index
  • 23 Article
  • 2 Comment/debate
  • 1 Chapter
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Article
2019
1 Citation (Scopus)

Dengue virus replication inhibition by dibenzothiepin derivatives

Mihai, D. P., Nitulescu, G. M., Smith, J. L., Hirsch, A. & Stecoza, C. E., Jan 1 2019, (Accepted/In press) In : Medicinal Chemistry Research.

Research output: Contribution to journalArticle

Dibenzothiepins
Thiepins
Dengue Virus
Virus Replication
Viruses
2018
2 Citations (Scopus)

Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions

Smith, J. L., Sheridan, K., Parkins, C. J., Frueh, L., Jemison, A. L., Strode, K., Dow, G., Nilsen, A. & Hirsch, A., Jul 1 2018, In : Antiviral Research. 155, p. 12-19 8 p.

Research output: Contribution to journalArticle

Dengue Virus
Capsid Proteins
Structure-Activity Relationship
Virion
Antiviral Agents
17 Citations (Scopus)

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Dudley, D. M., Van Rompay, K. K., Coffey, L. L., Ardeshir, A., Keesler, R. I., Bliss-Moreau, E., Grigsby, P., Steinbach, R. J., Hirsch, A., MacAllister, R., Pecoraro, H. L., Colgin, L., Hodge, T., Streblow, D., Tardif, S., Patterson, J. L., Tamhankar, M., Seferovic, M., Aagaard, K. M., Martín, C. S. S. & 18 others, Chiu, C. Y., Panganiban, A. T., Veazey, R. S., Wang, X., Maness, N. J., Gilbert, M. H., Bohm, R. P., Adams Waldorf, K. M., Gale, M., Rajagopal, L., Hotchkiss, C. E., Mohr, E. L., Capuano, S. V., Simmons, H. A., Mejia, A., Friedrich, T. C., Golos, T. G. & O’Connor, D. H., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1104-1107 4 p.

Research output: Contribution to journalArticle

Stillbirth
Spontaneous Abortion
Viruses
Primates
Mothers
33 Citations (Scopus)

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Hirsch, A., Roberts, V., Grigsby, P., Haese, N., Schabel, M., Wang, X., Lo, J., Liu, Z., Kroenke, C. C., Smith, J. L., Kelleher, M., Broeckel, R., Kreklywich, C. N., Parkins, C. J., Denton, M., Smith, P., De Filippis, V., Messer, W., Nelson, J., Hennebold, J. & 12 others, Grafe, M., Colgin, L., Lewis, A., Ducore, R., Swanson, T., Legasse, A. W., Axthelm, M., MacAllister, R., Moses, A., Morgan, T., Frias, A. & Streblow, D., Dec 1 2018, In : Nature Communications. 9, 1, 263.

Research output: Contribution to journalArticle

viruses
infectious diseases
Fetal Development
Macaca mulatta
Viruses
2017
32 Citations (Scopus)

A microRNA screen identifies the Wnt signaling pathway as a regulator of the interferon response during flavivirus infection

Smith, J. L., Jeng, S., McWeeney, S. & Hirsch, A., Apr 1 2017, In : Journal of Virology. 91, 8, e02388-16.

Research output: Contribution to journalArticle

Flavivirus Infections
Flavivirus
Wnt Signaling Pathway
interferons
MicroRNAs
12 Citations (Scopus)

A novel agonist of the trif pathway induces a cellular state refractory to replication of Zika, Chikungunya, and dengue viruses

Pryke, K. M., Abraham, J., Sali, T. M., Gall, B. J., Archer, I., Liu, A., Bambina, S., Baird, J., Gough, M., Chakhtoura, M., Haddad, E. K., Kirby, I. T., Nilsen, A., Streblow, D., Hirsch, A., Smith, J. L. & De Filippis, V., May 1 2017, In : mBio. 8, 3, e00452-17.

Research output: Contribution to journalArticle

Chikungunya virus
Dengue Virus
Interferon Type I
Adaptive Immunity
Interferon Regulatory Factor-3
96 Citations (Scopus)

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Hirsch, A., Smith, J. L., Haese, N. N., Broeckel, R. M., Parkins, C. J., Kreklywich, C., De Filippis, V., Denton, M., Smith, P. P., Messer, W., Colgin, L., Ducore, R., Grigsby, P., Hennebold, J., Swanson, T., Legasse, A. W., Axthelm, M., MacAllister, R., Wiley, C. A., Nelson, J. & 1 others, Streblow, D., Mar 1 2017, In : PLoS Pathogens. 13, 3, e1006219.

Research output: Contribution to journalArticle

Macaca mulatta
Conjunctivitis
Exanthema
Fever
Joints
2014
23 Citations (Scopus)

Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling

Smith, J. L., Stein, D. A., Shum, D., Fischer, M. A., Radu, C., Bhinder, B., Djaballah, H., Nelson, J., Frueh, K. & Hirsch, A., 2014, In : Journal of Virology. 88, 10, p. 5533-5542 10 p.

Research output: Contribution to journalArticle

Dopamine D4 Receptors
Dengue virus
Dengue Virus
Virus Replication
virus replication
2013
16 Citations (Scopus)

Flaviviruses are sensitive to inhibition of thymidine synthesis pathways

Fischer, M. A., Smith, J. L., Shum, D., Stein, D. A., Parkins, C., Bhinder, B., Radu, C., Hirsch, A., Djaballah, H., Nelson, J. & Frueh, K., 2013, In : Journal of Virology. 87, 17, p. 9411-9419 9 p.

Research output: Contribution to journalArticle

Flaviviridae
Flavivirus
Dengue virus
Dengue Virus
thymidine
2012
42 Citations (Scopus)

Induction of the cellular microRNA, Hs_154, by west nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors

Smith, J. L., Grey, F. E., Uhrlaub, J. L., Nikolich-Zugich, J. & Hirsch, A., May 2012, In : Journal of Virology. 86, 9, p. 5278-5287 10 p.

Research output: Contribution to journalArticle

West Nile virus
MicroRNAs
microRNA
apoptosis
Apoptosis
2011
34 Citations (Scopus)

Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence

Stein, D. A., Perry, S. T., Buck, M. D., Oehmen, C. S., Fischer, M. A., Poore, E., Smith, J. L., Lancaster, A. M., Hirsch, A., Slifka, M., Nelson, J., Shresta, S. & Frueh, K., Oct 2011, In : Journal of Virology. 85, 19, p. 10154-10166 13 p.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
conserved sequences
Conserved Sequence
Virus Diseases
2010
52 Citations (Scopus)

High-content assay to identify inhibitors of dengue virus infection

Shum, D., Smith, J. L., Hirsch, A., Bhinder, B., Radu, C., Stein, D. A., Nelson, J., Frueh, K. & Djaballah, H., Oct 1 2010, In : Assay and Drug Development Technologies. 8, 5, p. 553-570 18 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Drug Repositioning
Small Molecule Libraries
Virus Attachment
14 Citations (Scopus)

Immune response to the West Nile virus in aged non- human primates

Wertheimer, A. M., Uhrlaub, J. L., Hirsch, A., Medigeshi, G., Sprague, J., Legasse, A., Wilk, J., Wiley, C. A., Didier, P., Tesh, R. B., Murray, K. O., Axthelm, M., Wong, S. & Nikolich-Žugich, J., 2010, In : PLoS One. 5, 12, e15514.

Research output: Contribution to journalArticle

West Nile virus
Viruses
Primates
immune response
Macaca
43 Citations (Scopus)

The use of RNAi-based screens to identify host proteins involved in viral replication

Hirsch, A., Feb 2010, In : Future Microbiology. 5, 2, p. 303-311 9 p.

Research output: Contribution to journalArticle

RNA Interference
Proteins
Flavivirus
Human Genome
Virus Replication
2009
87 Citations (Scopus)

Key role of T cell defects in age-related vulnerability to West Nile virus

Brien, J. D., Uhrlaub, J. L., Hirsch, A., Wiley, C. A. & Nikolich-Žugich, J., Nov 23 2009, In : Journal of Experimental Medicine. 206, 12, p. 2735-2745 11 p.

Research output: Contribution to journalArticle

West Nile virus
T-Lymphocytes
Virus Diseases
Immunity
Brain
41 Citations (Scopus)

West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function

Medigeshi, G. R., Hirsch, A., Brien, J. D., Uhrlaub, J. L., Mason, P. W., Wiley, C., Nikolich-Zugich, J. & Nelson, J., Jun 2009, In : Journal of Virology. 83, 12, p. 6125-6134 10 p.

Research output: Contribution to journalArticle

Claudins
West Nile virus
capsid
Capsid
protein degradation
2008
92 Citations (Scopus)

West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of αvβ3 integrin

Medigeshi, G. R., Hirsch, A., Streblow, D., Nikolich-Zugich, J. & Nelson, J., Jun 2008, In : Journal of Virology. 82, 11, p. 5212-5219 8 p.

Research output: Contribution to journalArticle

Membrane Microdomains
West Nile virus
Virus Internalization
integrins
Integrins
2007
10 Citations (Scopus)

Sultam thiourea inhibition of West Nile virus

Barklis, E., Still, A., Sabri, M. I., Hirsch, A., Nikolich-Zugich, J., Brien, J., Dhenub, T. C., Scholz, I. & Alfadhli, A., Jul 2007, In : Antimicrobial Agents and Chemotherapy. 51, 7, p. 2642-2645 4 p.

Research output: Contribution to journalArticle

West Nile virus
Thiourea
Virus Replication
Replicon
naphthosultone
136 Citations (Scopus)

West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis

Medigeshi, G. R., Lancaster, A. M., Hirsch, A., Briese, T., Lipkin, W. I., De Filippis, V., Frueh, K., Mason, P. W., Nikolich-Zugich, J. & Nelson, J., Oct 2007, In : Journal of Virology. 81, 20, p. 10849-10860 12 p.

Research output: Contribution to journalArticle

unfolded protein response
Unfolded Protein Response
West Nile virus
Virus Diseases
apoptosis
2005
61 Citations (Scopus)

The Src family kinase c-Yes is required for maturation of West Nile virus particles

Hirsch, A., Medigeshi, G. R., Meyers, H. L., De Filippis, V., Frueh, K., Briese, T., Lipkin, W. I. & Nelson, J., Sep 2005, In : Journal of Virology. 79, 18, p. 11943-11951 9 p.

Research output: Contribution to journalArticle

West Nile virus
src-Family Kinases
virion
Virion
phosphotransferases (kinases)
2004
49 Citations (Scopus)

Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Gα12

Melnychuk, R. M., Streblow, D., Smith, P. P., Hirsch, A., Pancheva, D. & Nelson, J., Aug 2004, In : Journal of Virology. 78, 15, p. 8382-8391 10 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
G-Protein-Coupled Receptors
Cytomegalovirus
G-proteins
GTP-Binding Proteins
1999
47 Citations (Scopus)

Human cytomegalovirus inhibits transcription of the CC chemokine MCP-1 gene

Hirsch, A. & Shenk, T., 1999, In : Journal of Virology. 73, 1, p. 404-410 7 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
CC Chemokines
1-methylcyclopropene
Cytomegalovirus
transcription (genetics)
1994
40 Citations (Scopus)

A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis

Armand, P., Knapp, A. C., Hirsch, A., Wieschaus, E. F. & Cole, M. D., Jun 1994, In : Molecular and Cellular Biology. 14, 6, p. 4145-4154 10 p.

Research output: Contribution to journalArticle

Epidermis
Drosophila
Muscles
Proteins
MM Form Creatine Kinase