Research Output 1987 2019

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2014
42 Citations (Scopus)

A comprehensive thalamocortical projection map at the mesoscopic level

Hunnicutt, B. J., Long, B. R., Kusefoglu, D., Gertz, K. J., Zhong, H. & Mao, T., Sep 1 2014, In : Nature Neuroscience. 17, 9, p. 1276-1285 10 p.

Research output: Contribution to journalArticle

Thalamus
Optogenetics
Injections
Executive Function
Synapses
5 Citations (Scopus)

An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST

Cargnin, F., Nechiporuk, T., Müllendorff, K., Stumpo, D. J., Blackshear, P. J., Ballas, N. & Mandel, G., Dec 10 2014, In : Journal of Neuroscience. 34, 50, p. 16650-16661 12 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Neurons
Phenotype
Ganglia
Nervous System
7 Citations (Scopus)

A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses

Park, J. Y., Mott, M., Williams, T., Ikeda, H., Wen, H., Linhoff, M. & Ono, F., 2014, In : Journal of Neuroscience. 34, 31, p. 10211-10218 8 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Synapses
Neuromuscular Junction
Muscles
Mutation
81 Citations (Scopus)

Channel formation by yeast F-ATP synthase and the role of dimerization in the mitochondrial permeability transition

Carraro, M., Giorgio, V., Sileikyte, J., Sartori, G., Forte, M., Lippe, G., Zoratti, M., Szabò, I. & Bernardi, P., Jun 6 2014, In : Journal of Biological Chemistry. 289, 23, p. 15980-15985 6 p.

Research output: Contribution to journalArticle

Dimerization
Yeast
Permeability
Adenosine Triphosphate
Yeasts

Channel formation by yeast F-ATP synthase and the role of dimerization in the mitochondrial permeability transition

Carraro, M., Giorgio, V., Sileikyte, J., Sartori, G., Forte, M., Lippe, G., Zoratti, M., Szabò, I. & Bernardi, P., Jun 6 2014, In : Journal of Biological Chemistry. 289, 23, p. 15980-15985 6 p.

Research output: Contribution to journalArticle

Dimerization
Yeast
Permeability
Adenosine Triphosphate
Yeasts
6 Citations (Scopus)

Coassembly and coupling of SK2 channels and mGlu5 receptors

García-Negredo, G., Soto, D., Llorente, J., Morató, X., Galenkamp, K. M. O., Gómez-Soler, M., Fernández-Dueñas, V., Watanabe, M., Adelman, J., Shigemoto, R., Fukazawa, Y., Luján, R. & Ciruela, F., Oct 29 2014, In : Journal of Neuroscience. 34, 44, p. 14793-14802 10 p.

Research output: Contribution to journalArticle

Apamin
Calcium-Activated Potassium Channels
Metabotropic Glutamate Receptors
Pyramidal Cells
Protein Transport
15 Citations (Scopus)

Corepressor Rcor1 is essential for murine erythropoiesis

Yao, H., Goldman, D., Nechiporuk, T., Kawane, S., McWeeney, S., Tyner, J., Fan, G., Kerenyi, M. A., Orkin, S. H., Fleming, W. & Mandel, G., May 15 2014, In : Blood. 123, 20, p. 3175-3184 10 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Erythropoiesis
Genes
Erythroblasts
Colony-Stimulating Factor Receptors
34 Citations (Scopus)

Critical roles of a small conductance Ca2+-activated K + channel (SK3) in the repolarization process of atrial myocytes

Zhang, X. D., Timofeyev, V., Li, N., Myers, R. E., Zhang, D. M., Singapuri, A., Lau, V. C., Bond, C. T., Adelman, J., Lieu, D. K. & Chiamvimonvat, N., Feb 2014, In : Cardiovascular Research. 101, 2, p. 317-325 9 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Muscle Cells
Action Potentials
pamidronate
Cardiac Myocytes
21 Citations (Scopus)

C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation

Nesti, E., Corson, G. M., McCleskey, M., Oyer, J. A. & Mandel, G., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. E3929-E3936

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Stem Cells
Neurogenesis
Phosphorylation
cis-trans-Isomerases
11 Citations (Scopus)

Desensitization of functional μ-opioid receptors increases agonist off-rate

Williams, J., 2014, In : Molecular Pharmacology. 86, 1, p. 52-61 10 p.

Research output: Contribution to journalArticle

Opioid Receptors
Photolysis
Opioid Analgesics
Leucine Enkephalin
GTP-Binding Proteins
14 Citations (Scopus)

Differential subcellular localization of SK3-containing channels in the hippocampus

Ballesteros-Merino, C., Watanabe, M., Shigemoto, R., Fukazawa, Y., Adelman, J. & Luján, R., 2014, In : European Journal of Neuroscience. 39, 6, p. 883-892 10 p.

Research output: Contribution to journalArticle

Hippocampus
Post-Synaptic Density
Calcium-Activated Potassium Channels
Dendritic Spines
Neuronal Plasticity
28 Citations (Scopus)

Distinct Ca2+ sources in dendritic spines of hippocampal CA1 Neurons Couple to SK and Kv4 Channels

Wang, K., Lin, M. T., Adelman, J. & Maylie, J., Jan 22 2014, In : Neuron. 81, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Dendritic Spines
Excitatory Postsynaptic Potentials
Neurons
N-Methyl-D-Aspartate Receptors
Dialysis
56 Citations (Scopus)

Dual-transmitter neurons: Functional implications of co-release and co-transmission

Vaaga, C. E., Borisovska, M. & Westbrook, G., 2014, In : Current Opinion in Neurobiology. 29, p. 25-32 8 p.

Research output: Contribution to journalArticle

Neurotransmitter Agents
Neurons
Product Packaging
Phenotype
Wounds and Injuries
11 Citations (Scopus)

Fatty acids increase neuronal hypertrophy of Pten knockdown neurons

Fricano, C. J., DeSpenza, T., Frazel, P. W., Li, M., James O'Malley, A., Westbrook, G. & Luikart, B. W., Apr 23 2014, In : Frontiers in Molecular Neuroscience. 7, 1 APR, 30.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Hypertrophy
Fatty Acids
Neurons
S 6
50 Citations (Scopus)

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

Penmatsa, A. & Gouaux, E., Mar 1 2014, In : Journal of Physiology. 592, 5, p. 863-869 7 p.

Research output: Contribution to journalArticle

Neurotransmitter Transport Proteins
Leucine
Sodium
Neurotransmitter Agents
Symporters
18 Citations (Scopus)

Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation

Orfila, J. E., Shimizu, K., Garske, A. K., Deng, G., Maylie, J., Traystman, R. J., Quillinan, N., Adelman, J. & Herson, P. S., Oct 1 2014, In : European Journal of Neuroscience. 40, 8, p. 3179-3188 10 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Potassium Channels
Cardiopulmonary Resuscitation
Heart Arrest
Ischemia
20 Citations (Scopus)

Live imaging of endogenous PSD-95 using ENABLED: A conditional strategy to fluorescently label endogenous proteins

Fortin, D. A., Tillo, S. E., Yang, G., Rah, J. C., Melander, J. B., Bai, S., Soler-Cedeño, O., Qin, M., Zemelman, B. V., Guo, C., Mao, T. & Zhong, H., Dec 10 2014, In : Journal of Neuroscience. 34, 50, p. 16698-16712 15 p.

Research output: Contribution to journalArticle

Exons
Neurons
Proteins
Parvalbumins
Dendritic Spines
2 Citations (Scopus)

Localization of SK2 channels relative to excitatory synaptic sites in the mouse developing Purkinje cells

Ballesteros-Merino, C., Martínez-Hernández, J., Aguado, C., Watanabe, M., Adelman, J. & Luján, R., Dec 15 2014, In : Frontiers in Neuroanatomy. 8, DEC, 154.

Research output: Contribution to journalArticle

Dendritic Spines
Purkinje Cells
Light
Calcium-Activated Potassium Channels
Immunoelectron Microscopy
11 Citations (Scopus)

Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons

Schnell, E., Long, T. H., Bensen, A. L., Washburn, E. K. & Westbrook, G., 2014, In : Frontiers in Neuroscience. 8 APR, 71.

Research output: Contribution to journalArticle

Neurons
Dendrites
Cell Survival
Spine
Growth
9 Citations (Scopus)
Closed Head Injuries
Neurogenesis
Nervous System
Wounds and Injuries
Injury Severity Score
250 Citations (Scopus)

NMDA receptor structures reveal subunit arrangement and pore architecture

Lee, C. H., Lü, W., Michel, J. C., Goehring, A., Du, J., Song, X. & Gouaux, E., 2014, In : Nature. 511, 7508, p. 191-197 7 p.

Research output: Contribution to journalArticle

Ion Channels
Magnesium
Dizocilpine Maleate
Xenopus laevis
Molecular Structure
37 Citations (Scopus)

Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns

Arcila, M. L., Betizeau, M., Cambronne, X., Guzman, E., Doerflinger, N., Bouhallier, F., Zhou, H., Wu, B., Rani, N., Bassett, D. S., Borello, U., Huissoud, C., Goodman, R., Dehay, C. & Kosik, K. S., Mar 19 2014, In : Neuron. 81, 6, p. 1255-1262 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Primates
Genes
Lateral Ventricles
Cerebral Cortex
28 Citations (Scopus)

Phase-locking precision is enhanced by multiquantal release at an auditory hair cell ribbon synapse

Li, G. L., Cho, S. & Von Gersdorff, H., 2014, In : Neuron. 83, 6, p. 1404-1417 14 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Synapses
Cochlear Nerve
Synaptic Potentials
Excitatory Postsynaptic Potentials
19 Citations (Scopus)
Auditory Hair Cells
Exocytosis
Synapses
Protons
HEPES
100 Citations (Scopus)

Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (translocator protein of 18 kDa (TSPO))

Šileikyte, J., Blachly-Dyson, E., Sewell, R., Carpi, A., Menabò, R., Di Lisa, F., Ricchelli, F., Bernardi, P. & Forte, M., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 13769-13781 13 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Membranes
Proteins
Permeability
Mitochondrial Membranes
118 Citations (Scopus)

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

Goehring, A., Lee, C. H., Wang, K. H., Michel, J. C., Claxton, D. P., Baconguis, I., Althoff, T., Fischer, S., Garcia, K. C. & Gouaux, E., Nov 27 2014, In : Nature Protocols. 9, 11, p. 2574-2585 12 p.

Research output: Contribution to journalArticle

Baculoviridae
Screening
Membrane Proteins
Cells
Acid Sensing Ion Channels
72 Citations (Scopus)

Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal

Matsui, A., Jarvie, B. C., Robinson, B. G., Hentges, S. T. & Williams, J., Jun 18 2014, In : Neuron. 82, 6, p. 1346-1356 11 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Nucleus Accumbens
gamma-Aminobutyric Acid
Opioid Analgesics
Interneurons
15 Citations (Scopus)

Specialized postsynaptic morphology enhances neurotransmitter dilution and high-frequency signaling at an auditory synapse

Graydon, C. W., Cho, S., Diamond, J. S., Kachar, B., Von Gersdorff, H. & Grimes, W. N., 2014, In : Journal of Neuroscience. 34, 24, p. 8358-8372 15 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Synapses
Neurotransmitter Agents
Extracellular Space
Rana pipiens
117 Citations (Scopus)

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states

Dürr, K. L., Chen, L., Stein, R. A., De Zorzi, R., Folea, I. M., Walz, T., McHaourab, H. S. & Gouaux, E., Aug 14 2014, In : Cell. 158, 4, p. 778-792 15 p.

Research output: Contribution to journalArticle

Ionotropic Glutamate Receptors
AMPA Receptors
Electron resonance
Electrons
Ligands
7 Citations (Scopus)

Subdiffractive microscopy: Techniques, applications, and challenges

Long, B. R., Robinson, D. C. & Zhong, H., Mar 2014, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 6, 2, p. 151-168 18 p.

Research output: Contribution to journalArticle

Microscopy
Microscopic examination
Macromolecular Substances
Molecular Dynamics Simulation
Fluorescence
44 Citations (Scopus)

The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation

Willer, T., Inamori, K. I., Venzke, D., Harvey, C., Morgensen, G., Hara, Y., Beltrán Valero de Bernabé, D., Yu, L., Wright, K. & Campbell, K. P., 2014, In : eLife. 3

Research output: Contribution to journalArticle

Dystroglycans
Glycosylation
Glucuronosyltransferase
Xylose
Ligands
3 Citations (Scopus)

The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist

Vaaga, C. E., Tovar, K. R. & Westbrook, G., Sep 15 2014, In : Journal of Neurophysiology. 112, 6, p. 1241-1245 5 p.

Research output: Contribution to journalArticle

glycyl-prolyl-glutamic acid
N-Methyl-D-Aspartate Receptors
Glutamic Acid
Brain
Ionotropic Glutamate Receptors
26 Citations (Scopus)

The rare DAT coding variant Val559 perturbs da neuron function, changes behavior, and alters in vivo responses to psychostimulants

Mergy, M. A., Gowrishankar, R., Gresch, P. J., Gantz, S. C., Williams, J., Davis, G. L., Wheeler, C. A., Stanwood, G. D., Hahn, M. K. & Blakely, R. D., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. E4779-E4788

Research output: Contribution to journalArticle

Dopamine
Neurons
Aptitude
Dopamine Plasma Membrane Transport Proteins
Dopamine D2 Receptors
13 Citations (Scopus)
Phosphatidylinositol 3-Kinases
Cardiac Myocytes
Somatomedins
Sheep
Phosphorylation
133 Citations (Scopus)

X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na+-selective channel

Baconguis, I., Bohlen, C. J., Goehring, A., Julius, D. & Gouaux, E., Feb 13 2014, In : Cell. 156, 4, p. 717-729 13 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Snakes
Degenerin Sodium Channels
X-Rays
Epithelial Sodium Channels
74 Citations (Scopus)

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.

Chen, L., Dürr, K. L. & Gouaux, E., 2014, In : Science. 345, 6200, p. 1021-1026 6 p.

Research output: Contribution to journalArticle

AMPA Receptors
Snails
X-Rays
Ligands
Ion Channel Gating
144 Citations (Scopus)

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

Althoff, T., Hibbs, R. E., Banerjee, S. & Gouaux, E., Aug 21 2014, In : Nature. 512, 7514, p. 333-337 5 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Ion Channels
Ivermectin
X-Rays
Caenorhabditis elegans
2013
13 Citations (Scopus)

Activation of axonal receptors by GABA spillover increases somatic firing

Pugh, J. R. & Jahr, C., 2013, In : Journal of Neuroscience. 33, 43, p. 16924-16929 6 p.

Research output: Contribution to journalArticle

GABA Receptors
Axons
Carisoprodol
GABA-A Receptors
gamma-Aminobutyric Acid
18 Citations (Scopus)

Activation of extrasynaptic NMDARs at individual parallel fiber-molecular layer interneuron synapses in cerebellum

Nahir, B. & Jahr, C., 2013, In : Journal of Neuroscience. 33, 41, p. 16323-16333 11 p.

Research output: Contribution to journalArticle

Interneurons
N-Methyl-D-Aspartate Receptors
Synapses
Cerebellum
Neuronal Plasticity
125 Citations (Scopus)

Allosteric activation of functionally asymmetric RAF kinase dimers

Hu, J., Stites, E. C., Yu, H., Germino, E. A., Meharena, H. S., Stork, P., Kornev, A. P., Taylor, S. S. & Shaw, A. S., Aug 29 2013, In : Cell. 154, 5, p. 1036-1046 11 p.

Research output: Contribution to journalArticle

Dimers
Phosphotransferases
Chemical activation
Phosphorylation
Dimerization
19 Citations (Scopus)

A selective 5-HT1a receptor agonist improves respiration in a mouse model of Rett syndrome

Levitt, E. S., Hunnicutt, B. J., Knopp, S. J., Williams, J. & Bissonnette, J. M., Dec 1 2013, In : Journal of Applied Physiology. 115, 11, p. 1626-1633 8 p.

Research output: Contribution to journalArticle

Rett Syndrome
Methyl-CpG-Binding Protein 2
Respiration
Apnea
G Protein-Coupled Inwardly-Rectifying Potassium Channels
10 Citations (Scopus)

BH3-only proteins Noxa, Bik, Bmf, and Bid activate Bax and Bak indirectly when studied in yeast model

Gérecová, G., Kopanicová, J., Jaká, P., Běhalová, L., Juhásová, B., Bhatia-Kiššová, I., Forte, M., Polčic, P. & Mentel, M., Dec 2013, In : FEMS Yeast Research. 13, 8, p. 747-754 8 p.

Research output: Contribution to journalArticle

Noxae
Yeasts
Proteins
Cell Death
bcl-2 Homologous Antagonist-Killer Protein
2 Citations (Scopus)

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

Dillon, T. J., Takahashi, M., Li, Y., Tavisala, S., Murray, S., Moran, A., Parker, D. & Stork, P., Apr 2013, In : International Immunology. 25, 4, p. 259-269 11 p.

Research output: Contribution to journalArticle

Thymocytes
raf Kinases
MAP Kinase Signaling System
T-Cell Antigen Receptor
Thymus Gland
13 Citations (Scopus)

Caged naloxone reveals opioid signaling deactivation kineticss

Banghart, M. R., Williams, J., Shah, R. C., Lavis, L. D. & Sabatini, B. L., Nov 2013, In : Molecular Pharmacology. 84, 5, p. 687-695 9 p.

Research output: Contribution to journalArticle

Opioid Receptors
Naloxone
Opioid Analgesics
Photolysis
Locus Coeruleus
14 Citations (Scopus)

Comparative phosphoproteomics reveals components of host cell invasion and post-transcriptional regulation during francisella infection

Nakayasu, E. S., Tempel, R., Cambronne, X., Petyuk, V. A., Jones, M. B., Gritsenko, M. A., Monroe, M. E., Yang, F., Smith, R. D., Adkins, J. N. & Heffron, F., Nov 2013, In : Molecular and Cellular Proteomics. 12, 11, p. 3297-3309 13 p.

Research output: Contribution to journalArticle

Francisella
Tristetraprolin
Cellular Structures
Phosphorylation
Cell death
90 Citations (Scopus)

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y. J., Yao, H., Trowbridge, J. J., Mandel, G. & Orkin, S. H., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6518-6523 6 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Co-Repressor Proteins
Globins
Erythroid Cells
Methyltransferases
489 Citations (Scopus)

Dimers of mitochondrial ATP synthase form the permeability transition pore

Giorgio, V., Von Stockum, S., Antoniel, M., Fabbro, A., Fogolari, F., Forte, M., Glick, G. D., Petronilli, V., Zoratti, M., Szabó, I., Lippe, G. & Bernardi, P., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 5887-5892 6 p.

Research output: Contribution to journalArticle

Mitochondrial Proton-Translocating ATPases
Permeability
Adenosine Triphosphate
Benzodiazepines
Voltage-Dependent Anion Channels
37 Citations (Scopus)

Distinct modes of dopamine and GABA release in a dual transmitter neuron

Borisovska, M., Bensen, A. L., Chong, G. & Westbrook, G., Jan 30 2013, In : Journal of Neuroscience. 33, 5, p. 1790-1796 7 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Dopamine
Neurons
Vesicular Monoamine Transport Proteins
Neurotransmitter Agents
31 Citations (Scopus)

Dysmyelination of auditory afferent axons increases the jitter of action potential timing during high-frequency firing

Kim, J. H., Renden, R. & Von Gersdorff, H., May 29 2013, In : Journal of Neuroscience. 33, 22, p. 9402-9407 6 p.

Research output: Contribution to journalArticle

Action Potentials
Axons
Long Evans Rats
Myelin Sheath
Brain Stem
3 Citations (Scopus)

Hierarchical excitatory synaptic connectivity in mouse olfactory cortex

McGinley, M. J. & Westbrook, G., Oct 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 16193-16198 6 p.

Research output: Contribution to journalArticle

Automatic Data Processing
Pyramidal Cells
Patch-Clamp Techniques
Analysis of Variance
Olfactory Cortex