Research Output 1987 2019

2019

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Zhao, Y., Chen, S., Swensen, A. C., Qian, W. J. & Gouaux, E., Apr 26 2019, In : Science. 364, 6438, p. 355-362 8 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
AMPA Receptors
Ion Channel Gating
Molecular Structure
Synapses

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

Jones, B. E., Tovar, K. R., Goehring, A., Jalali-Yazdi, F., Okada, N. J., Gouaux, E. & Westbrook, G., Jul 10 2019, In : Science Translational Medicine. 11, 500, eaaw0044.

Research output: Contribution to journalArticle

Vaccination
Encephalitis
Autoimmunity
Autoantibodies
Antibody-Producing Cells
1 Citation (Scopus)

Designing azobenzene-based tools for controlling neurotransmission

Leippe, P. & Frank, J., Aug 1 2019, In : Current Opinion in Structural Biology. 57, p. 23-30 8 p.

Research output: Contribution to journalReview article

Synaptic Transmission
Neurosciences
Ion Channels
Synapses
Pathology

Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

Okawa, H., Yu, W. Q., Matti, U., Schwarz, K., Odermatt, B., Zhong, H., Tsukamoto, Y., Lagnado, L., Rieke, F., Schmitz, F. & Wong, R. O. L., Dec 1 2019, In : Nature communications. 10, 1, 2167.

Research output: Contribution to journalArticle

Open Access
synapses
vertebrates
Synapses
ribbons
maintenance
3 Citations (Scopus)

Dystroglycan is a scaffold for extracellular axon guidance decisions

Lindenmaier, L. B., Parmentier, N., Guo, C., Tissir, F. & Wright, K., Feb 13 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Dystroglycans
Scaffolds
Cues
Extracellular Matrix Proteins
Axons
Synapses
Hippocampal Mossy Fibers
Optogenetics
Temporal Lobe Epilepsy
Presynaptic Terminals

Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L

Chatzi, C., Zhang, Y., Hendricks, W. D., Chen, Y., Schnell, E., Goodman, R. & Westbrook, G., Jun 24 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Dendritic Spines
Excitatory Postsynaptic Potentials
Neurons
Microdissection
Laser Capture Microdissection

F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria

Ling, T. Y., Yi, F., Lu, T., Wang, X. L., Sun, X., Willis, M. S., Wu, L. Q., Shen, W. K., Adelman, J. & Lee, H. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 11, p. 4160-4168 9 p.

Research output: Contribution to journalArticle

Open Access
Small-Conductance Calcium-Activated Potassium Channels
F-Box Proteins
Medical problems
Proteasome Endopeptidase Complex
Diabetes Mellitus

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease

Murphy, E., Bernardi, P., Cohen, M., Di Lisa, F., Forte, M., Molkentin, J. D. & Ovize, M., Apr 26 2019, In : Circulation research. 124, 9, p. 1294-1296 3 p.

Research output: Contribution to journalComment/debate

Open Access
Heart Diseases
Reactive Oxygen Species
Mitochondria
Heart Failure
Phosphorylation

Glia in the skin activate pain responses

Doan, R. A. & Monk, K., Aug 16 2019, In : Science. 365, 6454, p. 641-642 2 p.

Research output: Contribution to journalShort survey

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

Smith, G. A., Lin, T. H., Sheehan, A. E., Van der Goes van Naters, W., Neukomm, L. J., Graves, H. K., Bis-Brewer, D. M., Züchner, S. & Freeman, M., Jul 3 2019, In : Neuron. 103, 1, p. 52-65.e6

Research output: Contribution to journalArticle

Open Access
Glutathione Disulfide
Glutathione Transferase
Mitochondrial Dynamics
Glutathione
Axons

In memoriam Peter H. Seeburg

Adelman, J., Jan 1 2019, In : Cell and Tissue Research. 375, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

2 Citations (Scopus)

Insights into the mechanism and pharmacology of neurotransmitter sodium symporters

Navratna, V. & Gouaux, E., Feb 1 2019, In : Current Opinion in Structural Biology. 54, p. 161-170 10 p.

Research output: Contribution to journalReview article

Plasma Membrane Neurotransmitter Transport Proteins
Neurotransmitter Agents
Pharmacology
Ligands
Molecular Structure

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

Jackman, S., Chen, C. H. & Regehr, W. G., Feb 26 2019, In : Journal of visualized experiments : JoVE. 144

Research output: Contribution to journalArticle

Optogenetics
Silk
Viruses
Brain
Fibroins

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

Harty, B. L., Coelho, F., Pease-Raissi, S. E., Mogha, A., Ackerman, S. D., Herbert, A. L., Gereau, R. W., Golden, J. P., Lyons, D. A., Chan, J. R. & Monk, K., Dec 1 2019, In : Nature communications. 10, 1, 2976.

Research output: Contribution to journalArticle

Open Access
axons
Ubiquitin-Protein Ligases
Schwann Cells
Axons
Neurology

Next-generation interfaces for studying neural function

Frank, J., Antonini, M. J. & Anikeeva, P., Jan 1 2019, (Accepted/In press) In : Nature biotechnology.

Research output: Contribution to journalReview article

Disease control
Optical communication
Neurons
Brain
Biochemical Phenomena

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Kol, M., Williams, B., Toombs-Ruane, H., Franquelim, H. G., Korneev, S., Schroeer, C., Schwille, P., Trauner, D., Holthuis, J. C. & Frank, J., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Sphingolipids
Ceramides
Biosynthesis
ceramide glucosyltransferase
Light
4 Citations (Scopus)

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Kliewer, A., Schmiedel, F., Sianati, S., Bailey, A., Bateman, J. T., Levitt, E. S., Williams, J., Christie, M. J. & Schulz, S., Dec 1 2019, In : Nature Communications. 10, 1, 367.

Research output: Contribution to journalArticle

analgesia
phosphorylation
Phosphorylation
Opioid Receptors
GTP-Binding Proteins
1 Citation (Scopus)

Presynaptic diversity revealed by Ca 2+ -permeable AMPA receptors at the calyx of held synapse

Lujan, B., Dagostin, A. & Von Gersdorff, H., Apr 17 2019, In : Journal of Neuroscience. 39, 16, p. 2981-2994 14 p.

Research output: Contribution to journalArticle

AMPA Receptors
Synapses
Hearing
Action Potentials
Brain Stem
3 Citations (Scopus)

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

Coleman, J. A., Yang, D., Zhao, Z., Wen, P. C., Yoshioka, C., Tajkhorshid, E. & Gouaux, E., Jan 1 2019, In : Nature.

Research output: Contribution to journalLetter

Ibogaine
Serotonin Plasma Membrane Transport Proteins
Plasma Membrane Neurotransmitter Transport Proteins
Serotonin
Neurotransmitter Agents
1 Citation (Scopus)

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

Campbell, N. G., Shekar, A., Aguilar, J. I., Peng, D., Navratna, V., Yang, D., Morley, A. N., Duran, A. M., Galli, G., O’Grady, B., Ramachandran, R., Sutcliffe, J. S., Sitte, H. H., Erreger, K., Meiler, J., Stockner, T., Bellan, L. M., Matthies, H. J. G., Gouaux, E., Mchaourab, H. S. & 1 others, Galli, A., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3853-3862 10 p.

Research output: Contribution to journalArticle

Dopamine
Dopamine Plasma Membrane Transport Proteins
X Ray Crystallography
Electron Spin Resonance Spectroscopy
Brain Diseases
1 Citation (Scopus)

Structural basis for mammalian nucleotide sugar transport

Ahuja, S. & Whorton, M., Apr 15 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Sugars
Nucleotides
Cytidine Monophosphate N-Acetylneuraminic Acid
Glycosylation
Substrates
3 Citations (Scopus)

Structure and mechanism of AMPA receptor — auxiliary protein complexes

Chen, S. & Gouaux, E., Feb 1 2019, In : Current Opinion in Structural Biology. 54, p. 104-111 8 p.

Research output: Contribution to journalReview article

AMPA Receptors
Proteins
Cryoelectron Microscopy
Ionotropic Glutamate Receptors
Kainic Acid Receptors

Synapse-specific opioid modulation of thalamo-cortico-striatal circuits

Birdsong, W. T., Jongbloets, B. C., Engeln, K. A., Wang, D., Scherrer, G. & Mao, T., May 1 2019, In : eLife. 8, e41356.

Research output: Contribution to journalArticle

Open Access
Corpus Striatum
Gyrus Cinguli
Thalamus
Synapses
Opioid Analgesics
1 Citation (Scopus)

The accessible chromatin landscape of the murine hippocampus at single-cell resolution

Sinnamon, J. R., Torkenczy, K. A., Linhoff, M. W., Vitak, S. A., Mulqueen, R. M., Pliner, H. A., Trapnell, C., Steemers, F. J., Mandel, G. & Adey, A., May 1 2019, In : Genome Research. 29, 5, p. 857-869 13 p.

Research output: Contribution to journalArticle

Open Access
Chromatin
Hippocampus
Transposases
Neurons
Pyramidal Cells

The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors

Morgan, R. K., Anderson, G. R., Araç, D., Aust, G., Balenga, N., Boucard, A., Bridges, J. P., Engel, F. B., Formstone, C. J., Glitsch, M. D., Gray, R. S., Hall, R. A., Hsiao, C. C., Kim, H. Y., Knierim, A. B., Kusuluri, D. K., Leon, K., Liebscher, I., Piao, X., Prömel, S. & 12 others, Scholz, N., Srivastava, S., Thor, D., Tolias, K. F., Ushkaryov, Y. A., Vallon, M., Van Meir, E. G., Vanhollebeke, B., Wolfrum, U., Wright, K., Monk, K. & Mogha, A., Jan 1 2019, In : Annals of the New York Academy of Sciences.

Research output: Contribution to journalComment/debate

GTP-Binding Proteins
Adhesion
Education
1 Citation (Scopus)

The Mitochondrial Permeability Transition in Mitochondrial Disorders

Šileikytė, J. & Forte, M., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1 p.

Research output: Contribution to journalReview article

Open Access
Mitochondrial Diseases
Permeability
Chemical activation
Mitochondrial Proton-Translocating ATPases
Membranes
Optical Imaging
Cyclic AMP-Dependent Protein Kinases
Photons
Microscopy
Microscopic examination
2018
6 Citations (Scopus)

A Highly Sensitive A-Kinase Activity Reporter for Imaging Neuromodulatory Events in Awake Mice

Ma, L., Jongbloets, B. C., Xiong, W-H., Melander, J. B., Qin, M., Lameyer, T. J., Harrison, M. F., Zemelman, B. V., Mao, T. & Zhong, H., Aug 22 2018, In : Neuron. 99, 4, p. 665-679.e5

Research output: Contribution to journalArticle

Protein Kinases
Phosphotransferases
Optical Imaging
Photons
Neurotransmitter Agents

Allegro giusto: piccolo, bassoon and clarinet set the tempo of vesicle pool replenishment

Dagostin, A., Kushmerick, C. & Von Gersdorff, H., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1315-1316 2 p.

Research output: Contribution to journalArticle

frovatriptan
5 Citations (Scopus)

Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome

Rakela, B., Brehm, P. & Mandel, G., Jan 9 2018, In : eLife. 7, e31629.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rett Syndrome
Astrocytes
Modulation
Defects

Blocking slow exocytosis with slow Ca2+ buffers slows recovery from depression

Jackman, S. & Von Gersdorff, H., Oct 1 2018, In : Journal of Physiology. 596, 19, p. 4555-4557 3 p.

Research output: Contribution to journalComment/debate

Exocytosis
Buffers

Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation

Vahedi-Hunter, T. A., Estep, J. A., Rosette, K. A., Rutlin, M. L., Wright, K. & Riccomagno, M. M., Dec 1 2018, In : Scientific Reports. 8, 1, 5996.

Research output: Contribution to journalArticle

Spinal Ganglia
Fasciculation
Proteins
Peripheral Nervous System
Cues
4 Citations (Scopus)

Cellular tolerance at the µ-opioid receptor is phosphorylation dependent

Arttamangkul, S., Heinz, D. A., Bunzow, J. R., Song, X. & Williams, J., Mar 28 2018, In : eLife. 7, e34989.

Research output: Contribution to journalArticle

Phosphorylation
Opioid Receptors
Morphine
Wild Animals
Locus Coeruleus
2 Citations (Scopus)

Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses

Vincent, P. F. Y., Cho, S., Tertrais, M., Bouleau, Y., Von Gersdorff, H. & Dulon, D., Dec 18 2018, In : Cell Reports. 25, 12, p. 3451-3464.e3

Research output: Contribution to journalArticle

Synaptic Vesicles
Inner Auditory Hair Cells
Synapses
Protons
Cells
Acid Sensing Ion Channels
crystallography
Crystallography
Organized Financing
Divalent Cations
18 Citations (Scopus)

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

Phulera, S., Zhu, H., Yu, J., Claxton, D. P., Yoder, N., Yoshioka, C. & Gouaux, E., Jul 25 2018, In : eLife. 7, e39383.

Research output: Contribution to journalArticle

GABA-A Receptors
Benzodiazepines
gamma-Aminobutyric Acid
Ion Channels
Cysteine Loop Ligand-Gated Ion Channel Receptors
2 Citations (Scopus)

Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat

Carlin, D., Golden, J. P., Mogha, A., Samineni, V. K., Monk, K., Gereau, R. W. & Cavalli, V., Mar 1 2018, In : eNeuro. 5, 2

Research output: Contribution to journalArticle

Nociceptors
Tuberous Sclerosis
Ion Channels
Hot Temperature
Sensory Receptor Cells

Desensitization and Tolerance of Mu Opioid Receptors on Pontine Kölliker-Fuse Neurons

Levitt, E. S. & Williams, J., Jan 1 2018, In : Molecular Pharmacology. 93, 1, p. 8-13 6 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Neurons
Locus Coeruleus
Morphine
Opioid Analgesics
3 Citations (Scopus)

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography

Yoder, N. & Gouaux, E., Aug 1 2018, In : PLoS One. 13, 8, e0202134.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
crystallography
Crystallography
Divalent Cations
ion channels

Epilepsy-specific citation classics revisited

Kellogg, M., Westbrook, G. & Spencer, D., Mar 1 2018, In : Epilepsy Currents. 18, 2, p. 72-83 12 p.

Research output: Contribution to journalReview article

Epilepsy
Dimming (lamps)
Rage
Mammals
mammals
Light
1 Citation (Scopus)

Expression and purification of a functional heteromeric GABAA receptor for structural studies

Claxton, D. P. & Gouaux, E., Jul 1 2018, In : PLoS One. 13, 7, e0201210.

Research output: Contribution to journalArticle

GABA-A Receptors
Purification
receptors
gamma-Aminobutyric Acid
Cysteine Loop Ligand-Gated Ion Channel Receptors

Flow Cytometry Analysis of Free Intracellular NAD+ Using a Targeted Biosensor

Eller, J. M., Stewart, M. L., Slepian, A. J., Markwardt, S., Wiedrick, J., Cohen, M., Goodman, R. & Cambronne, X., Jan 1 2018, (Accepted/In press) In : Current Protocols in Cytometry. e54.

Research output: Contribution to journalArticle

Flow cytometry
Biosensing Techniques
Biosensors
NAD
Flow Cytometry
4 Citations (Scopus)

Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior

Cho, S., Muthukumar, A. K., Stork, W. T., Coutinho-Budd, J. C. & Freeman, M., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11316-11321 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Focal Adhesions
Astrocytes
Seizures
Matrix Metalloproteinase 1
23 Citations (Scopus)

Gating mechanisms of acid-sensing ion channels

Yoder, N., Yoshioka, C. & Gouaux, E., Mar 15 2018, In : Nature. 555, 7696, p. 397-401 5 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Thumb
Protons
Degenerin Sodium Channels
Chickens
7 Citations (Scopus)

GPR56/ADG RG1 regulates development and maintenance of peripheral myelin

Ackerman, S. D., Luo, R., Poitelon, Y., Mogha, A., Harty, B. L., D'Rozario, M., Sanchez, N. E., Lakkaraju, A. K. K., Gamble, P., Li, J., Qu, J., MacEwan, M. R., Ray, W. Z., Aguzzi, A., Feltri, M. L., Piao, X. & Monk, K., Mar 1 2018, In : Journal of Experimental Medicine. 215, 3, p. 941-961 21 p.

Research output: Contribution to journalArticle

Myelin Sheath
Schwann Cells
Maintenance
Peripheral Nervous System
Axons

Influences: Sodium channel excitement

Mandel, G., Aug 1 2018, In : Journal of General Physiology. 150, 8, p. 1047-1049 3 p.

Research output: Contribution to journalArticle

Sodium Channels
2 Citations (Scopus)

Live imaging of Schwann cell development in zebrafish

Cunningham, R. L. & Monk, K., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 401-405 5 p. (Methods in Molecular Biology; vol. 1739).

Research output: Chapter in Book/Report/Conference proceedingChapter

Schwann Cells
Zebrafish
Larva
4 Citations (Scopus)

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Peters, O. M., Lewis, E. A., Osterloh, J. M., Weiss, A., Salameh, J. S., Metterville, J., Brown, R. H. & Freeman, M., Nov 1 2018, In : Human Molecular Genetics. 27, 21, p. 3761-3771 11 p.

Research output: Contribution to journalArticle

Nerve Degeneration
Amyotrophic Lateral Sclerosis
Motor Neurons
Axons
Axotomy