Research Output

2020

A Lipid Photoswitch Controls Fluidity in Supported Bilayer Membranes

Urban, P., Pritzl, S. D., Ober, M. F., Dirscherl, C. F., Pernpeintner, C., Konrad, D. B., Frank, J. A., Trauner, D., Nickel, B. & Lohmueller, T., Mar 17 2020, In : Langmuir. 36, 10, p. 2629-2634 6 p.

Research output: Contribution to journalArticle

A novel class of cardioprotective small-molecule PTP inhibitors

Antonucci, S., Di Sante, M., Sileikyte, J., Deveraux, J., Bauer, T., Bround, M. J., Menabò, R., Paillard, M., Alanova, P., Carraro, M., Ovize, M., Molkentin, J. D., Cohen, M., Forte, M. A., Bernardi, P., Di Lisa, F. & Murphy, E., Jan 2020, In : Pharmacological Research. 151, 104548.

Research output: Contribution to journalArticle

2 Scopus citations

Photoactivatable Dopamine and Sulpiride to Explore the Function of Dopaminergic Neurons and Circuits

Asad, N., Mclain, D. E., Condon, A. F., Gore, S., Hampton, S. E., Vijay, S., Williams, J. T. & Dore, T. M., Mar 18 2020, In : ACS Chemical Neuroscience. 11, 6, p. 939-951 13 p.

Research output: Contribution to journalArticle

Open Access

Title: Cerebellar purkinje cell activity modulates aggressive behavior

Jackman, S. L., Chen, C. H., Offermann, H. L., Drew, I. R., Harrison, B. M., Bowman, A. M., Flick, K. M., Flaquer, I. & Regehr, W. G., Apr 2020, In : eLife. 9

Research output: Contribution to journalArticle

Open Access

α2δ-2 Protein Controls Structure and Function at the Cerebellar Climbing Fiber Synapse

Beeson, K. A., Beeson, R., Westbrook, G. L. & Schnell, E., Mar 18 2020, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 40, 12, p. 2403-2415 13 p.

Research output: Contribution to journalArticle

2019

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Zhao, Y., Chen, S., Swensen, A. C., Qian, W. J. & Gouaux, E., Apr 26 2019, In : Science. 364, 6438, p. 355-362 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

Jones, B. E., Tovar, K. R., Goehring, A., Jalali-Yazdi, F., Okada, N. J., Gouaux, E. & Westbrook, G., Jul 10 2019, In : Science Translational Medicine. 11, 500, eaaw0044.

Research output: Contribution to journalArticle

4 Scopus citations

Designing azobenzene-based tools for controlling neurotransmission

Leippe, P. & Frank, J., Aug 1 2019, In : Current Opinion in Structural Biology. 57, p. 23-30 8 p.

Research output: Contribution to journalReview article

3 Scopus citations

Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

Okawa, H., Yu, W. Q., Matti, U., Schwarz, K., Odermatt, B., Zhong, H., Tsukamoto, Y., Lagnado, L., Rieke, F., Schmitz, F. & Wong, R. O. L., Dec 1 2019, In : Nature communications. 10, 1, 2167.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Dystroglycan is a scaffold for extracellular axon guidance decisions

Lindenmaier, L. B., Parmentier, N., Guo, C., Tissir, F. & Wright, K. M., Feb 2019, In : eLife. 8, e42143.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L

Chatzi, C., Zhang, Y., Hendricks, W. D., Chen, Y., Schnell, E., Goodman, R. & Westbrook, G., Jun 24 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria

Ling, T. Y., Yi, F., Lu, T., Wang, X. L., Sun, X., Willis, M. S., Wu, L. Q., Shen, W. K., Adelman, J. P. & Lee, H. C., Mar 15 2019, In : Journal of Biological Chemistry. 294, 11, p. 4160-4168 9 p.

Research output: Contribution to journalArticle

Open Access

Flow Cytometry Analysis of Free Intracellular NAD+ Using a Targeted Biosensor

Eller, J. M., Stewart, M. L., Slepian, A. J., Markwardt, S., Wiedrick, J., Cohen, M. S., Goodman, R. H. & Cambronne, X. A., Apr 2019, In : Current Protocols in Cytometry. 88, 1, e54.

Research output: Contribution to journalArticle

1 Scopus citations

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease

Murphy, E., Bernardi, P., Cohen, M., Di Lisa, F., Forte, M., Molkentin, J. D. & Ovize, M., Apr 26 2019, In : Circulation research. 124, 9, p. 1294-1296 3 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Glia in the skin activate pain responses

Doan, R. A. & Monk, K., Aug 16 2019, In : Science. 365, 6454, p. 641-642 2 p.

Research output: Contribution to journalShort survey

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

Smith, G. A., Lin, T. H., Sheehan, A. E., Van der Goes van Naters, W., Neukomm, L. J., Graves, H. K., Bis-Brewer, D. M., Züchner, S. & Freeman, M. R., Jul 3 2019, In : Neuron. 103, 1, p. 52-65.e6

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Healthy attachments: Cell adhesion molecules collectively control myelin integrity

Li, J. & Monk, K. R., Sep 1 2019, In : Journal of Cell Biology. 218, 9, p. 2824-2825 2 p.

Research output: Contribution to journalShort survey

Open Access

How to build a fast and highly sensitive sound detector that remains robust to temperature shifts

Chen, M. & Von Gersdorff, H., Sep 11 2019, In : Journal of Neuroscience. 39, 37, p. 7260-7276 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators

Patriarchi, T., Cho, J. R., Merten, K., Marley, A., Broussard, G. J., Liang, R., Williams, J., Nimmerjahn, A., von Zastrow, M., Gradinaru, V. & Tian, L., Dec 1 2019, In : Nature protocols. 14, 12, p. 3471-3505 35 p.

Research output: Contribution to journalArticle

2 Scopus citations

In memoriam Peter H. Seeburg

Adelman, J., Jan 1 2019, In : Cell and Tissue Research. 375, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

Insights into the mechanism and pharmacology of neurotransmitter sodium symporters

Navratna, V. & Gouaux, E., Feb 2019, In : Current Opinion in Structural Biology. 54, p. 161-170 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

Jackman, S., Chen, C. H. & Regehr, W. G., Feb 26 2019, In : Journal of visualized experiments : JoVE. 144

Research output: Contribution to journalArticle

1 Scopus citations

Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem

Milinkeviciute, G., Henningfield, C. M., Muniak, M. A., Chokr, S. M., Green, K. N. & Cramer, K. S., Aug 28 2019, In : Frontiers in Neural Circuits. 13, 55.

Research output: Contribution to journalArticle

Open Access

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

Harty, B. L., Coelho, F., Pease-Raissi, S. E., Mogha, A., Ackerman, S. D., Herbert, A. L., Gereau, R. W., Golden, J. P., Lyons, D. A., Chan, J. R. & Monk, K. R., Dec 1 2019, In : Nature communications. 10, 1, 2976.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis

Kant, S., Craige, S. M., Chen, K., Reif, M. M., Learnard, H., Kelly, M., Caliz, A. D., Tran, K. V., Ramo, K., Peters, O. M., Freeman, M., Davis, R. J. & Keaney, J. F., Dec 1 2019, In : Nature communications. 10, 1, 4223.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Next-generation interfaces for studying neural function

Frank, J. A., Antonini, M. J. & Anikeeva, P., Sep 1 2019, In : Nature biotechnology. 37, 9, p. 1013-1023 11 p.

Research output: Contribution to journalReview article

9 Scopus citations

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Kol, M., Williams, B., Toombs-Ruane, H., Franquelim, H. G., Korneev, S., Schroeer, C., Schwille, P., Trauner, D., Holthuis, J. C. & Frank, J., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Kliewer, A., Schmiedel, F., Sianati, S., Bailey, A., Bateman, J. T., Levitt, E. S., Williams, J. T., Christie, M. J. & Schulz, S., Dec 1 2019, In : Nature communications. 10, 1, 367.

Research output: Contribution to journalArticle

37 Scopus citations

Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Gu, P., Gong, J., Shang, Y., Wang, F., Ruppell, K. T., Ma, Z., Sheehan, A. E., Freeman, M. R. & Xiang, Y., Dec 2 2019, In : Current Biology. 29, 23, p. 3961-3973.e6

Research output: Contribution to journalArticle

Presynaptic diversity revealed by Ca2+-permeable AMPA receptors at the calyx of held synapse

Lujan, B., Dagostin, A. & Von Gersdorff, H., Apr 17 2019, In : Journal of Neuroscience. 39, 16, p. 2981-2994 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

Robinson, B. G., Cai, X., Wang, J., Bunzow, J. R., Williams, J. T. & Kaeser, P. S., Sep 2019, In : eLife. 8, e47972.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Separation of acute desensitization and long-term tolerance of m-opioid receptors is determined by the degree of C-terminal phosphorylation

Arttamangkul, S., Leff, E. R., Koita, O., Birdsong, W. T. & Williams, J. T., Oct 2019, In : Molecular pharmacology. 96, 4, p. 505-514 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

Coleman, J. A., Yang, D., Zhao, Z., Wen, P. C., Yoshioka, C., Tajkhorshid, E. & Gouaux, E., May 2 2019, In : Nature. 569, 7754, p. 141-145 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

Campbell, N. G., Shekar, A., Aguilar, J. I., Peng, D., Navratna, V., Yang, D., Morley, A. N., Duran, A. M., Galli, G., O’Grady, B., Ramachandran, R., Sutcliffe, J. S., Sitte, H. H., Erreger, K., Meiler, J., Stockner, T., Bellan, L. M., Matthies, H. J. G., Gouaux, E., Mchaourab, H. S. & 1 others, Galli, A., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3853-3862 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structural basis for mammalian nucleotide sugar transport

Ahuja, S. & Whorton, M., Apr 15 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Structure and mechanism of AMPA receptor — auxiliary protein complexes

Chen, S. & Gouaux, E., Feb 1 2019, In : Current Opinion in Structural Biology. 54, p. 104-111 8 p.

Research output: Contribution to journalReview article

6 Scopus citations

Synapse-specific opioid modulation of thalamo-cortico-striatal circuits

Birdsong, W. T., Jongbloets, B. C., Engeln, K. A., Wang, D., Scherrer, G. & Mao, T., May 1 2019, In : eLife. 8, e41356.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

The accessible chromatin landscape of the murine hippocampus at single-cell resolution

Sinnamon, J. R., Torkenczy, K. A., Linhoff, M. W., Vitak, S. A., Mulqueen, R. M., Pliner, H. A., Trapnell, C., Steemers, F. J., Mandel, G. & Adey, A., May 1 2019, In : Genome Research. 29, 5, p. 857-869 13 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The expanding functional roles and signaling mechanisms of adhesion g protein–coupled receptors

Morgan, R. K., Anderson, G. R., Araç, D., Aust, G., Balenga, N., Boucard, A., Bridges, J. P., Engel, F. B., Formstone, C. J., Glitsch, M. D., Gray, R. S., Hall, R. A., Hsiao, C. C., Kim, H. Y., Knierim, A. B., Kusuluri, D. K., Leon, K., Liebscher, I., Piao, X., Prömel, S. & 12 others, Scholz, N., Srivastava, S., Thor, D., Tolias, K. F., Ushkaryov, Y. A., Vallon, M., Van Meir, E. G., Vanhollebeke, B., Wolfrum, U., Wright, K. M., Monk, K. R. & Mogha, A., Jan 1 2019, Annals of the New York Academy of Sciences. 1 ed. Blackwell Publishing Inc., p. 5-25 21 p. (Annals of the New York Academy of Sciences; vol. 1456, no. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

The mitochondrial permeability transition in mitochondrial disorders

Šileikytė, J. & Forte, M., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 3403075.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

Arttamangkul, S., Plazek, A., Platt, E. J., Jin, H., Murray, T. F., Birdsong, W. T., Rice, K. C., Farrens, D. L. & Williams, J. T., Oct 7 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations

Zebrafish neuromuscular junction: The power of N

Brehm, P. & Wen, H., Nov 20 2019, In : Neuroscience Letters. 713, 134503.

Research output: Contribution to journalReview article

2018

A Highly Sensitive A-Kinase Activity Reporter for Imaging Neuromodulatory Events in Awake Mice

Ma, L., Jongbloets, B. C., Xiong, W-H., Melander, J. B., Qin, M., Lameyer, T. J., Harrison, M. F., Zemelman, B. V., Mao, T. & Zhong, H., Aug 22 2018, In : Neuron. 99, 4, p. 665-679.e5

Research output: Contribution to journalArticle

14 Scopus citations

Allegro giusto: piccolo, bassoon and clarinet set the tempo of vesicle pool replenishment

Dagostin, A., Kushmerick, C. & Von Gersdorff, H., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1315-1316 2 p.

Research output: Contribution to journalArticle

Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome

Rakela, B., Brehm, P. & Mandel, G., Jan 9 2018, In : eLife. 7, e31629.

Research output: Contribution to journalArticle

9 Scopus citations

Blocking slow exocytosis with slow Ca2+ buffers slows recovery from depression

Jackman, S. & Von Gersdorff, H., Oct 1 2018, In : Journal of Physiology. 596, 19, p. 4555-4557 3 p.

Research output: Contribution to journalComment/debate

Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation

Vahedi-Hunter, T. A., Estep, J. A., Rosette, K. A., Rutlin, M. L., Wright, K. M. & Riccomagno, M. M., Dec 1 2018, In : Scientific Reports. 8, 1, 5996.

Research output: Contribution to journalArticle