Research Output

2020

A novel class of cardioprotective small-molecule PTP inhibitors

Antonucci, S., Di Sante, M., Sileikyte, J., Deveraux, J., Bauer, T., Bround, M. J., Menabò, R., Paillard, M., Alanova, P., Carraro, M., Ovize, M., Molkentin, J. D., Cohen, M., Forte, M. A., Bernardi, P., Di Lisa, F. & Murphy, E., Jan 2020, In : Pharmacological Research. 151, 104548.

Research output: Contribution to journalArticle

2019

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Zhao, Y., Chen, S., Swensen, A. C., Qian, W. J. & Gouaux, E., Apr 26 2019, In : Science. 364, 6438, p. 355-362 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

Jones, B. E., Tovar, K. R., Goehring, A., Jalali-Yazdi, F., Okada, N. J., Gouaux, E. & Westbrook, G., Jul 10 2019, In : Science Translational Medicine. 11, 500, eaaw0044.

Research output: Contribution to journalArticle

1 Scopus citations

Designing azobenzene-based tools for controlling neurotransmission

Leippe, P. & Frank, J., Aug 1 2019, In : Current Opinion in Structural Biology. 57, p. 23-30 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

Okawa, H., Yu, W. Q., Matti, U., Schwarz, K., Odermatt, B., Zhong, H., Tsukamoto, Y., Lagnado, L., Rieke, F., Schmitz, F. & Wong, R. O. L., Dec 1 2019, In : Nature communications. 10, 1, 2167.

Research output: Contribution to journalArticle

Open Access

Dystroglycan is a scaffold for extracellular axon guidance decisions

Lindenmaier, L. B., Parmentier, N., Guo, C., Tissir, F. & Wright, K., Feb 13 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L

Chatzi, C., Zhang, Y., Hendricks, W. D., Chen, Y., Schnell, E., Goodman, R. & Westbrook, G., Jun 24 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria

Ling, T. Y., Yi, F., Lu, T., Wang, X. L., Sun, X., Willis, M. S., Wu, L. Q., Shen, W. K., Adelman, J. & Lee, H. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 11, p. 4160-4168 9 p.

Research output: Contribution to journalArticle

Open Access

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease

Murphy, E., Bernardi, P., Cohen, M., Di Lisa, F., Forte, M., Molkentin, J. D. & Ovize, M., Apr 26 2019, In : Circulation research. 124, 9, p. 1294-1296 3 p.

Research output: Contribution to journalComment/debate

Open Access

Glia in the skin activate pain responses

Doan, R. A. & Monk, K., Aug 16 2019, In : Science. 365, 6454, p. 641-642 2 p.

Research output: Contribution to journalShort survey

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

Smith, G. A., Lin, T. H., Sheehan, A. E., Van der Goes van Naters, W., Neukomm, L. J., Graves, H. K., Bis-Brewer, D. M., Züchner, S. & Freeman, M., Jul 3 2019, In : Neuron. 103, 1, p. 52-65.e6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Healthy attachments: Cell adhesion molecules collectively control myelin integrity

Li, J. & Monk, K., Sep 2 2019, In : The Journal of cell biology. 218, 9, p. 2824-2825 2 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators

Patriarchi, T., Cho, J. R., Merten, K., Marley, A., Broussard, G. J., Liang, R., Williams, J., Nimmerjahn, A., von Zastrow, M., Gradinaru, V. & Tian, L., Dec 1 2019, In : Nature protocols. 14, 12, p. 3471-3505 35 p.

Research output: Contribution to journalArticle

1 Scopus citations

In memoriam Peter H. Seeburg

Adelman, J., Jan 1 2019, In : Cell and Tissue Research. 375, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

Insights into the mechanism and pharmacology of neurotransmitter sodium symporters

Navratna, V. & Gouaux, E., Feb 1 2019, In : Current Opinion in Structural Biology. 54, p. 161-170 10 p.

Research output: Contribution to journalReview article

4 Scopus citations

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

Jackman, S., Chen, C. H. & Regehr, W. G., Feb 26 2019, In : Journal of visualized experiments : JoVE. 144

Research output: Contribution to journalArticle

Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem

Milinkeviciute, G., Henningfield, C. M., Muniak, M. A., Chokr, S. M., Green, K. N. & Cramer, K. S., Aug 28 2019, In : Frontiers in Neural Circuits. 13, 55.

Research output: Contribution to journalArticle

Open Access

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

Harty, B. L., Coelho, F., Pease-Raissi, S. E., Mogha, A., Ackerman, S. D., Herbert, A. L., Gereau, R. W., Golden, J. P., Lyons, D. A., Chan, J. R. & Monk, K., Dec 1 2019, In : Nature communications. 10, 1, 2976.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis

Kant, S., Craige, S. M., Chen, K., Reif, M. M., Learnard, H., Kelly, M., Caliz, A. D., Tran, K. V., Ramo, K., Peters, O. M., Freeman, M., Davis, R. J. & Keaney, J. F., Dec 1 2019, In : Nature communications. 10, 1, 4223.

Research output: Contribution to journalArticle

Open Access

Next-generation interfaces for studying neural function

Frank, J., Antonini, M. J. & Anikeeva, P., Jan 1 2019, (Accepted/In press) In : Nature biotechnology.

Research output: Contribution to journalReview article

4 Scopus citations

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Kol, M., Williams, B., Toombs-Ruane, H., Franquelim, H. G., Korneev, S., Schroeer, C., Schwille, P., Trauner, D., Holthuis, J. C. & Frank, J., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Kliewer, A., Schmiedel, F., Sianati, S., Bailey, A., Bateman, J. T., Levitt, E. S., Williams, J., Christie, M. J. & Schulz, S., Dec 1 2019, In : Nature Communications. 10, 1, 367.

Research output: Contribution to journalArticle

20 Scopus citations

Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Gu, P., Gong, J., Shang, Y., Wang, F., Ruppell, K. T., Ma, Z., Sheehan, A. E., Freeman, M. R. & Xiang, Y., Dec 2 2019, In : Current Biology. 29, 23, p. 3961-3973.e6

Research output: Contribution to journalArticle

Presynaptic diversity revealed by Ca 2+ -permeable AMPA receptors at the calyx of held synapse

Lujan, B., Dagostin, A. & Von Gersdorff, H., Apr 17 2019, In : Journal of Neuroscience. 39, 16, p. 2981-2994 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

Robinson, B. G., Cai, X., Wang, J., Bunzow, J. R., Williams, J. T. & Kaeser, P. S., Sep 2019, In : eLife. 8, e47972.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Separation of Acute Desensitization and Long-Term Tolerance of µ-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation

Arttamangkul, S., Leff, E. R., Koita, O., Birdsong, W. T. & Williams, J. T., Oct 1 2019, In : Molecular pharmacology. 96, 4, p. 505-514 10 p.

Research output: Contribution to journalArticle

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

Coleman, J. A., Yang, D., Zhao, Z., Wen, P. C., Yoshioka, C., Tajkhorshid, E. & Gouaux, E., Jan 1 2019, In : Nature.

Research output: Contribution to journalLetter

9 Scopus citations

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

Campbell, N. G., Shekar, A., Aguilar, J. I., Peng, D., Navratna, V., Yang, D., Morley, A. N., Duran, A. M., Galli, G., O’Grady, B., Ramachandran, R., Sutcliffe, J. S., Sitte, H. H., Erreger, K., Meiler, J., Stockner, T., Bellan, L. M., Matthies, H. J. G., Gouaux, E., Mchaourab, H. S. & 1 others, Galli, A., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3853-3862 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structural basis for mammalian nucleotide sugar transport

Ahuja, S. & Whorton, M., Apr 15 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Structure and mechanism of AMPA receptor — auxiliary protein complexes

Chen, S. & Gouaux, E., Feb 1 2019, In : Current Opinion in Structural Biology. 54, p. 104-111 8 p.

Research output: Contribution to journalReview article

5 Scopus citations

Synapse-specific opioid modulation of thalamo-cortico-striatal circuits

Birdsong, W. T., Jongbloets, B. C., Engeln, K. A., Wang, D., Scherrer, G. & Mao, T., May 1 2019, In : eLife. 8, e41356.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The accessible chromatin landscape of the murine hippocampus at single-cell resolution

Sinnamon, J. R., Torkenczy, K. A., Linhoff, M. W., Vitak, S. A., Mulqueen, R. M., Pliner, H. A., Trapnell, C., Steemers, F. J., Mandel, G. & Adey, A., May 1 2019, In : Genome Research. 29, 5, p. 857-869 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors

Morgan, R. K., Anderson, G. R., Araç, D., Aust, G., Balenga, N., Boucard, A., Bridges, J. P., Engel, F. B., Formstone, C. J., Glitsch, M. D., Gray, R. S., Hall, R. A., Hsiao, C. C., Kim, H. Y., Knierim, A. B., Kusuluri, D. K., Leon, K., Liebscher, I., Piao, X., Prömel, S. & 12 others, Scholz, N., Srivastava, S., Thor, D., Tolias, K. F., Ushkaryov, Y. A., Vallon, M., Van Meir, E. G., Vanhollebeke, B., Wolfrum, U., Wright, K., Monk, K. & Mogha, A., Jan 1 2019, In : Annals of the New York Academy of Sciences.

Research output: Contribution to journalComment/debate

The Mitochondrial Permeability Transition in Mitochondrial Disorders

Šileikytė, J. & Forte, M., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1 p.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

Arttamangkul, S., Plazek, A., Platt, E. J., Jin, H., Murray, T. F., Birdsong, W. T., Rice, K. C., Farrens, D. L. & Williams, J. T., Oct 7 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

Zebrafish neuromuscular junction: The power of N

Brehm, P. & Wen, H., Nov 20 2019, In : Neuroscience Letters. 713, 134503.

Research output: Contribution to journalReview article

2018

A Highly Sensitive A-Kinase Activity Reporter for Imaging Neuromodulatory Events in Awake Mice

Ma, L., Jongbloets, B. C., Xiong, W-H., Melander, J. B., Qin, M., Lameyer, T. J., Harrison, M. F., Zemelman, B. V., Mao, T. & Zhong, H., Aug 22 2018, In : Neuron. 99, 4, p. 665-679.e5

Research output: Contribution to journalArticle

7 Scopus citations

Allegro giusto: piccolo, bassoon and clarinet set the tempo of vesicle pool replenishment

Dagostin, A., Kushmerick, C. & Von Gersdorff, H., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1315-1316 2 p.

Research output: Contribution to journalArticle

Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome

Rakela, B., Brehm, P. & Mandel, G., Jan 9 2018, In : eLife. 7, e31629.

Research output: Contribution to journalArticle

7 Scopus citations

Blocking slow exocytosis with slow Ca2+ buffers slows recovery from depression

Jackman, S. & Von Gersdorff, H., Oct 1 2018, In : Journal of Physiology. 596, 19, p. 4555-4557 3 p.

Research output: Contribution to journalComment/debate

Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation

Vahedi-Hunter, T. A., Estep, J. A., Rosette, K. A., Rutlin, M. L., Wright, K. & Riccomagno, M. M., Dec 1 2018, In : Scientific Reports. 8, 1, 5996.

Research output: Contribution to journalArticle

Cellular tolerance at the µ-opioid receptor is phosphorylation dependent

Arttamangkul, S., Heinz, D. A., Bunzow, J. R., Song, X. & Williams, J., Mar 28 2018, In : eLife. 7, e34989.

Research output: Contribution to journalArticle

10 Scopus citations

Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses

Vincent, P. F. Y., Cho, S., Tertrais, M., Bouleau, Y., Von Gersdorff, H. & Dulon, D., Dec 18 2018, In : Cell Reports. 25, 12, p. 3451-3464.e3

Research output: Contribution to journalArticle

5 Scopus citations

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

Phulera, S., Zhu, H., Yu, J., Claxton, D. P., Yoder, N., Yoshioka, C. & Gouaux, E., Jul 25 2018, In : eLife. 7, e39383.

Research output: Contribution to journalArticle

28 Scopus citations

Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat

Carlin, D., Golden, J. P., Mogha, A., Samineni, V. K., Monk, K., Gereau, R. W. & Cavalli, V., Mar 1 2018, In : eNeuro. 5, 2

Research output: Contribution to journalArticle

2 Scopus citations