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2020

A novel class of cardioprotective small-molecule PTP inhibitors

Antonucci, S., Di Sante, M., Sileikyte, J., Deveraux, J., Bauer, T., Bround, M. J., Menabò, R., Paillard, M., Alanova, P., Carraro, M., Ovize, M., Molkentin, J. D., Cohen, M., Forte, M. A., Bernardi, P., Di Lisa, F. & Murphy, E., Jan 2020, In : Pharmacological Research. 151, 104548.

Research output: Contribution to journalArticle

2019

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Zhao, Y., Chen, S., Swensen, A. C., Qian, W. J. & Gouaux, E., Apr 26 2019, In : Science. 364, 6438, p. 355-362 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

Jones, B. E., Tovar, K. R., Goehring, A., Jalali-Yazdi, F., Okada, N. J., Gouaux, E. & Westbrook, G., Jul 10 2019, In : Science Translational Medicine. 11, 500, eaaw0044.

Research output: Contribution to journalArticle

1 Scopus citations

Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

Okawa, H., Yu, W. Q., Matti, U., Schwarz, K., Odermatt, B., Zhong, H., Tsukamoto, Y., Lagnado, L., Rieke, F., Schmitz, F. & Wong, R. O. L., Dec 1 2019, In : Nature communications. 10, 1, 2167.

Research output: Contribution to journalArticle

Open Access

Dystroglycan is a scaffold for extracellular axon guidance decisions

Lindenmaier, L. B., Parmentier, N., Guo, C., Tissir, F. & Wright, K., Feb 13 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L

Chatzi, C., Zhang, Y., Hendricks, W. D., Chen, Y., Schnell, E., Goodman, R. & Westbrook, G., Jun 24 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria

Ling, T. Y., Yi, F., Lu, T., Wang, X. L., Sun, X., Willis, M. S., Wu, L. Q., Shen, W. K., Adelman, J. & Lee, H. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 11, p. 4160-4168 9 p.

Research output: Contribution to journalArticle

Open Access

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

Smith, G. A., Lin, T. H., Sheehan, A. E., Van der Goes van Naters, W., Neukomm, L. J., Graves, H. K., Bis-Brewer, D. M., Züchner, S. & Freeman, M., Jul 3 2019, In : Neuron. 103, 1, p. 52-65.e6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations

Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators

Patriarchi, T., Cho, J. R., Merten, K., Marley, A., Broussard, G. J., Liang, R., Williams, J., Nimmerjahn, A., von Zastrow, M., Gradinaru, V. & Tian, L., Dec 1 2019, In : Nature protocols. 14, 12, p. 3471-3505 35 p.

Research output: Contribution to journalArticle

1 Scopus citations

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

Jackman, S., Chen, C. H. & Regehr, W. G., Feb 26 2019, In : Journal of visualized experiments : JoVE. 144

Research output: Contribution to journalArticle

Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem

Milinkeviciute, G., Henningfield, C. M., Muniak, M. A., Chokr, S. M., Green, K. N. & Cramer, K. S., Aug 28 2019, In : Frontiers in Neural Circuits. 13, 55.

Research output: Contribution to journalArticle

Open Access

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

Harty, B. L., Coelho, F., Pease-Raissi, S. E., Mogha, A., Ackerman, S. D., Herbert, A. L., Gereau, R. W., Golden, J. P., Lyons, D. A., Chan, J. R. & Monk, K., Dec 1 2019, In : Nature communications. 10, 1, 2976.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis

Kant, S., Craige, S. M., Chen, K., Reif, M. M., Learnard, H., Kelly, M., Caliz, A. D., Tran, K. V., Ramo, K., Peters, O. M., Freeman, M., Davis, R. J. & Keaney, J. F., Dec 1 2019, In : Nature communications. 10, 1, 4223.

Research output: Contribution to journalArticle

Open Access

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Kol, M., Williams, B., Toombs-Ruane, H., Franquelim, H. G., Korneev, S., Schroeer, C., Schwille, P., Trauner, D., Holthuis, J. C. & Frank, J., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Kliewer, A., Schmiedel, F., Sianati, S., Bailey, A., Bateman, J. T., Levitt, E. S., Williams, J., Christie, M. J. & Schulz, S., Dec 1 2019, In : Nature Communications. 10, 1, 367.

Research output: Contribution to journalArticle

20 Scopus citations

Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Gu, P., Gong, J., Shang, Y., Wang, F., Ruppell, K. T., Ma, Z., Sheehan, A. E., Freeman, M. R. & Xiang, Y., Dec 2 2019, In : Current Biology. 29, 23, p. 3961-3973.e6

Research output: Contribution to journalArticle

Presynaptic diversity revealed by Ca 2+ -permeable AMPA receptors at the calyx of held synapse

Lujan, B., Dagostin, A. & Von Gersdorff, H., Apr 17 2019, In : Journal of Neuroscience. 39, 16, p. 2981-2994 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

Robinson, B. G., Cai, X., Wang, J., Bunzow, J. R., Williams, J. T. & Kaeser, P. S., Sep 2019, In : eLife. 8, e47972.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Separation of Acute Desensitization and Long-Term Tolerance of µ-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation

Arttamangkul, S., Leff, E. R., Koita, O., Birdsong, W. T. & Williams, J. T., Oct 1 2019, In : Molecular pharmacology. 96, 4, p. 505-514 10 p.

Research output: Contribution to journalArticle

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

Campbell, N. G., Shekar, A., Aguilar, J. I., Peng, D., Navratna, V., Yang, D., Morley, A. N., Duran, A. M., Galli, G., O’Grady, B., Ramachandran, R., Sutcliffe, J. S., Sitte, H. H., Erreger, K., Meiler, J., Stockner, T., Bellan, L. M., Matthies, H. J. G., Gouaux, E., Mchaourab, H. S. & 1 others, Galli, A., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3853-3862 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structural basis for mammalian nucleotide sugar transport

Ahuja, S. & Whorton, M., Apr 15 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Synapse-specific opioid modulation of thalamo-cortico-striatal circuits

Birdsong, W. T., Jongbloets, B. C., Engeln, K. A., Wang, D., Scherrer, G. & Mao, T., May 1 2019, In : eLife. 8, e41356.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The accessible chromatin landscape of the murine hippocampus at single-cell resolution

Sinnamon, J. R., Torkenczy, K. A., Linhoff, M. W., Vitak, S. A., Mulqueen, R. M., Pliner, H. A., Trapnell, C., Steemers, F. J., Mandel, G. & Adey, A., May 1 2019, In : Genome Research. 29, 5, p. 857-869 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

Arttamangkul, S., Plazek, A., Platt, E. J., Jin, H., Murray, T. F., Birdsong, W. T., Rice, K. C., Farrens, D. L. & Williams, J. T., Oct 7 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2018

A Highly Sensitive A-Kinase Activity Reporter for Imaging Neuromodulatory Events in Awake Mice

Ma, L., Jongbloets, B. C., Xiong, W-H., Melander, J. B., Qin, M., Lameyer, T. J., Harrison, M. F., Zemelman, B. V., Mao, T. & Zhong, H., Aug 22 2018, In : Neuron. 99, 4, p. 665-679.e5

Research output: Contribution to journalArticle

7 Scopus citations

Allegro giusto: piccolo, bassoon and clarinet set the tempo of vesicle pool replenishment

Dagostin, A., Kushmerick, C. & Von Gersdorff, H., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1315-1316 2 p.

Research output: Contribution to journalArticle

Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome

Rakela, B., Brehm, P. & Mandel, G., Jan 9 2018, In : eLife. 7, e31629.

Research output: Contribution to journalArticle

7 Scopus citations

Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation

Vahedi-Hunter, T. A., Estep, J. A., Rosette, K. A., Rutlin, M. L., Wright, K. & Riccomagno, M. M., Dec 1 2018, In : Scientific Reports. 8, 1, 5996.

Research output: Contribution to journalArticle

Cellular tolerance at the µ-opioid receptor is phosphorylation dependent

Arttamangkul, S., Heinz, D. A., Bunzow, J. R., Song, X. & Williams, J., Mar 28 2018, In : eLife. 7, e34989.

Research output: Contribution to journalArticle

10 Scopus citations

Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses

Vincent, P. F. Y., Cho, S., Tertrais, M., Bouleau, Y., Von Gersdorff, H. & Dulon, D., Dec 18 2018, In : Cell Reports. 25, 12, p. 3451-3464.e3

Research output: Contribution to journalArticle

5 Scopus citations

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

Phulera, S., Zhu, H., Yu, J., Claxton, D. P., Yoder, N., Yoshioka, C. & Gouaux, E., Jul 25 2018, In : eLife. 7, e39383.

Research output: Contribution to journalArticle

28 Scopus citations

Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat

Carlin, D., Golden, J. P., Mogha, A., Samineni, V. K., Monk, K., Gereau, R. W. & Cavalli, V., Mar 1 2018, In : eNeuro. 5, 2

Research output: Contribution to journalArticle

2 Scopus citations

Desensitization and Tolerance of Mu Opioid Receptors on Pontine Kölliker-Fuse Neurons

Levitt, E. S. & Williams, J., Jan 1 2018, In : Molecular Pharmacology. 93, 1, p. 8-13 6 p.

Research output: Contribution to journalArticle

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography

Yoder, N. & Gouaux, E., Aug 1 2018, In : PLoS One. 13, 8, e0202134.

Research output: Contribution to journalArticle

4 Scopus citations

Expression and purification of a functional heteromeric GABAA receptor for structural studies

Claxton, D. P. & Gouaux, E., Jul 1 2018, In : PLoS One. 13, 7, e0201210.

Research output: Contribution to journalArticle

1 Scopus citations

Flow Cytometry Analysis of Free Intracellular NAD+ Using a Targeted Biosensor

Eller, J. M., Stewart, M. L., Slepian, A. J., Markwardt, S., Wiedrick, J., Cohen, M., Goodman, R. & Cambronne, X., Jan 1 2018, (Accepted/In press) In : Current Protocols in Cytometry. e54.

Research output: Contribution to journalArticle

1 Scopus citations

Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior

Cho, S., Muthukumar, A. K., Stork, W. T., Coutinho-Budd, J. C. & Freeman, M., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11316-11321 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Gating mechanisms of acid-sensing ion channels

Yoder, N., Yoshioka, C. & Gouaux, E., Mar 15 2018, In : Nature. 555, 7696, p. 397-401 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

GPR56/ADG RG1 regulates development and maintenance of peripheral myelin

Ackerman, S. D., Luo, R., Poitelon, Y., Mogha, A., Harty, B. L., D'Rozario, M., Sanchez, N. E., Lakkaraju, A. K. K., Gamble, P., Li, J., Qu, J., MacEwan, M. R., Ray, W. Z., Aguzzi, A., Feltri, M. L., Piao, X. & Monk, K., Mar 1 2018, In : Journal of Experimental Medicine. 215, 3, p. 941-961 21 p.

Research output: Contribution to journalArticle

12 Scopus citations

Influences: Sodium channel excitement

Mandel, G., Aug 1 2018, In : Journal of General Physiology. 150, 8, p. 1047-1049 3 p.

Research output: Contribution to journalArticle

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Peters, O. M., Lewis, E. A., Osterloh, J. M., Weiss, A., Salameh, J. S., Metterville, J., Brown, R. H. & Freeman, M., Nov 1 2018, In : Human Molecular Genetics. 27, 21, p. 3761-3771 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanism of NMDA receptor channel block by MK-801 and memantine

Song, X., Jensen, M. O., Jogini, V., Stein, R. A., Lee, C. H., McHaourab, H. S., Shaw, D. E. & Gouaux, E., Apr 26 2018, In : Nature. 556, 7702, p. 515-519 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor

Jalali-Yazdi, F., Chowdhury, S., Yoshioka, C. & Gouaux, E., Nov 29 2018, In : Cell. 175, 6, p. 1520-1532.e15

Research output: Contribution to journalArticle

10 Scopus citations

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

Giera, S., Luo, R., Ying, Y., Ackerman, S. D., Jeong, S. J., Stoveken, H. M., Folts, C. J., Welsh, C. A., Tall, G. G., Stevens, B., Monk, K. & Piao, X., May 29 2018, In : eLife. 7, e33385.

Research output: Contribution to journalArticle

17 Scopus citations

Mutations in dock1 disrupt early Schwann cell development

Cunningham, R. L., Herbert, A. L., Harty, B. L., Ackerman, S. D. & Monk, K., Aug 8 2018, In : Neural Development. 13, 1, 17.

Research output: Contribution to journalArticle

1 Scopus citations

Neuronal activity induces glutathione metabolism gene expression in astrocytes

McGann, J. C. & Mandel, G., Sep 1 2018, In : GLIA. 66, 9, p. 2024-2039 16 p.

Research output: Contribution to journalArticle

2 Scopus citations