YAPping about differentiation therapy in muscle cancer

Matthew N. Svalina, Charles Keller

    Research output: Contribution to journalShort surveypeer-review

    7 Scopus citations

    Abstract

    Overcoming a presumed differentiation block in the childhood muscle cancer embryonal rhabdomyosarcoma is often thought to hold promise as an approach to replace cytotoxic chemotherapy with molecularly-targeted differentiation therapies. In this issue of Cancer Cell, Tremblay and colleagues implicate YAP1 and the Hippo signaling pathway in the maintenance of differentiation-arrested and proliferative phenotypes for embryonal rhabdomyosarcoma.

    Original languageEnglish (US)
    Pages (from-to)154-155
    Number of pages2
    JournalCancer Cell
    Volume26
    Issue number2
    DOIs
    StatePublished - Aug 11 2014

    ASJC Scopus subject areas

    • Oncology
    • Cell Biology
    • Cancer Research

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