WNK Kinase Signaling in Ion Homeostasis and Human Disease

Masoud Shekarabi, Jinwei Zhang, Arjun R. Khanna, David Ellison, Eric Delpire, Kristopher T. Kahle

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

Original languageEnglish (US)
Pages (from-to)285-299
Number of pages15
JournalCell Metabolism
Volume25
Issue number2
DOIs
StatePublished - Feb 7 2017

Fingerprint

Homeostasis
Phosphotransferases
Ions
Cell Size
gamma-Aminobutyric Acid
Nervous System
Cations
Epithelial Cells
Cell Proliferation
Kidney

Keywords

  • chloride
  • GABA
  • homeostasis
  • KCC2
  • KCC3
  • kidney
  • NCC
  • NKCC1
  • WNK1
  • WNK3
  • WNK4

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Shekarabi, M., Zhang, J., Khanna, A. R., Ellison, D., Delpire, E., & Kahle, K. T. (2017). WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism, 25(2), 285-299. https://doi.org/10.1016/j.cmet.2017.01.007

WNK Kinase Signaling in Ion Homeostasis and Human Disease. / Shekarabi, Masoud; Zhang, Jinwei; Khanna, Arjun R.; Ellison, David; Delpire, Eric; Kahle, Kristopher T.

In: Cell Metabolism, Vol. 25, No. 2, 07.02.2017, p. 285-299.

Research output: Contribution to journalReview article

Shekarabi, M, Zhang, J, Khanna, AR, Ellison, D, Delpire, E & Kahle, KT 2017, 'WNK Kinase Signaling in Ion Homeostasis and Human Disease', Cell Metabolism, vol. 25, no. 2, pp. 285-299. https://doi.org/10.1016/j.cmet.2017.01.007
Shekarabi M, Zhang J, Khanna AR, Ellison D, Delpire E, Kahle KT. WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism. 2017 Feb 7;25(2):285-299. https://doi.org/10.1016/j.cmet.2017.01.007
Shekarabi, Masoud ; Zhang, Jinwei ; Khanna, Arjun R. ; Ellison, David ; Delpire, Eric ; Kahle, Kristopher T. / WNK Kinase Signaling in Ion Homeostasis and Human Disease. In: Cell Metabolism. 2017 ; Vol. 25, No. 2. pp. 285-299.
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