WNK Kinase Signaling in Ion Homeostasis and Human Disease

Masoud Shekarabi; Jinwei Zhang; Arjun R. Khanna; David H. Ellison; Eric Delpire; Kristopher T. Kahle

doi:10.1016/j.cmet.2017.01.007

WNK Kinase Signaling in Ion Homeostasis and Human Disease

Masoud Shekarabi, Jinwei Zhang, Arjun R. Khanna, David H. Ellison, Eric Delpire, Kristopher T. Kahle

Oregon Clinical and Translational Research Institute

Research output: Contribution to journal › Review article › peer-review

150 Scopus citations

Abstract

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl⁻ cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

Original language	English (US)
Pages (from-to)	285-299
Number of pages	15
Journal	Cell Metabolism
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2017.01.007
State	Published - Feb 7 2017

Keywords

GABA
KCC2
KCC3
NCC
NKCC1
WNK1
WNK3
WNK4
chloride
homeostasis
kidney

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2017.01.007

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title = "WNK Kinase Signaling in Ion Homeostasis and Human Disease",

abstract = "WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl− cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.",

keywords = "GABA, KCC2, KCC3, NCC, NKCC1, WNK1, WNK3, WNK4, chloride, homeostasis, kidney",

author = "Masoud Shekarabi and Jinwei Zhang and Khanna, {Arjun R.} and Ellison, {David H.} and Eric Delpire and Kahle, {Kristopher T.}",

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T1 - WNK Kinase Signaling in Ion Homeostasis and Human Disease

AU - Shekarabi, Masoud

AU - Zhang, Jinwei

AU - Khanna, Arjun R.

AU - Ellison, David H.

AU - Delpire, Eric

AU - Kahle, Kristopher T.

PY - 2017/2/7

Y1 - 2017/2/7

N2 - WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl− cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

AB - WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl− cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

KW - GABA

KW - KCC2

KW - KCC3

KW - NCC

KW - NKCC1

KW - WNK1

KW - WNK3

KW - WNK4

KW - chloride

KW - homeostasis

KW - kidney

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WNK Kinase Signaling in Ion Homeostasis and Human Disease

Abstract

Keywords

ASJC Scopus subject areas

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