WNK Kinase Signaling in Ion Homeostasis and Human Disease

Masoud Shekarabi, Jinwei Zhang, Arjun R. Khanna, David H. Ellison, Eric Delpire, Kristopher T. Kahle

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

Original languageEnglish (US)
Pages (from-to)285-299
Number of pages15
JournalCell Metabolism
Volume25
Issue number2
DOIs
StatePublished - Feb 7 2017

Keywords

  • GABA
  • KCC2
  • KCC3
  • NCC
  • NKCC1
  • WNK1
  • WNK3
  • WNK4
  • chloride
  • homeostasis
  • kidney

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Shekarabi, M., Zhang, J., Khanna, A. R., Ellison, D. H., Delpire, E., & Kahle, K. T. (2017). WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism, 25(2), 285-299. https://doi.org/10.1016/j.cmet.2017.01.007