Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors

Juliann Chmielecki, Aimee M. Crago, Mara Rosenberg, Rachael O'Connor, Sarah R. Walker, Lauren Ambrogio, Daniel Auclair, Aaron McKenna, Michael C. Heinrich, David A. Frank, Matthew Meyerson

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    296 Scopus citations

    Abstract

    Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.

    Original languageEnglish (US)
    Pages (from-to)131-132
    Number of pages2
    JournalNature genetics
    Volume45
    Issue number2
    DOIs
    StatePublished - Feb 1 2013

    ASJC Scopus subject areas

    • Genetics

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  • Cite this

    Chmielecki, J., Crago, A. M., Rosenberg, M., O'Connor, R., Walker, S. R., Ambrogio, L., Auclair, D., McKenna, A., Heinrich, M. C., Frank, D. A., & Meyerson, M. (2013). Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nature genetics, 45(2), 131-132. https://doi.org/10.1038/ng.2522