Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
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Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. / Chmielecki, Juliann; Crago, Aimee M.; Rosenberg, Mara; O'Connor, Rachael; Walker, Sarah R.; Ambrogio, Lauren; Auclair, Daniel; McKenna, Aaron; Heinrich, Michael; Frank, David A.; Meyerson, Matthew.In: Nature Genetics, Vol. 45, No. 2, 02.2013, p. 131-132.
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