Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors

Juliann Chmielecki, Aimee M. Crago, Mara Rosenberg, Rachael O'Connor, Sarah R. Walker, Lauren Ambrogio, Daniel Auclair, Aaron McKenna, Michael C. Heinrich, David A. Frank, Matthew Meyerson

Research output: Contribution to journalArticlepeer-review

381 Scopus citations

Abstract

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.

Original languageEnglish (US)
Pages (from-to)131-132
Number of pages2
JournalNature genetics
Volume45
Issue number2
DOIs
StatePublished - Feb 2013

ASJC Scopus subject areas

  • Genetics

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