White matter connectivity and aerobic fitness in male adolescents

Megan M. Herting, John B. Colby, Elizabeth R. Sowell, Bonnie Nagel

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Exercise has been shown to have positive effects on the brain and behavior throughout various stages of the lifespan. However, little is known about the impact of exercise on neurodevelopment during the adolescent years, particularly with regard to white matter microstructure, as assessed by diffusion tensor imaging (DTI). Both tract-based spatial statistics (TBSS) and tractography-based along-tract statistics were utilized to examine the relationship between white matter microstructure and aerobic exercise in adolescent males, ages 15-18. Furthermore, we examined the data by both (1) grouping individuals based on aerobic fitness self-reports (high fit (HF) vs. low fit (LF)), and (2) using VO2 peak as a continuous variable across the entire sample. Results showed that HF youth had an overall higher number of streamline counts compared to LF peers, which was driven by group differences in corticospinal tract (CST) and anterior corpus callosum (Fminor). In addition, VO2 peak was negatively related to FA in the left CST. Together, these results suggest that aerobic fitness relates to white matter connectivity and microstructure in tracts carrying frontal and motor fibers during adolescence. Furthermore, the current study highlights the importance of considering the environmental factor of aerobic exercise when examining adolescent brain development.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalDevelopmental Cognitive Neuroscience
Volume7
DOIs
StatePublished - Jan 2014

Fingerprint

Exercise
Pyramidal Tracts
Adolescent Development
Diffusion Tensor Imaging
Corpus Callosum
Brain
Self Report
White Matter

Keywords

  • Adolescence
  • Aerobic exercise
  • Diffusion tensor imaging
  • Tractography
  • White matter

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

White matter connectivity and aerobic fitness in male adolescents. / Herting, Megan M.; Colby, John B.; Sowell, Elizabeth R.; Nagel, Bonnie.

In: Developmental Cognitive Neuroscience, Vol. 7, 01.2014, p. 65-75.

Research output: Contribution to journalArticle

Herting, Megan M. ; Colby, John B. ; Sowell, Elizabeth R. ; Nagel, Bonnie. / White matter connectivity and aerobic fitness in male adolescents. In: Developmental Cognitive Neuroscience. 2014 ; Vol. 7. pp. 65-75.
@article{87aabe29580e4b749c56abd9510b55f3,
title = "White matter connectivity and aerobic fitness in male adolescents",
abstract = "Exercise has been shown to have positive effects on the brain and behavior throughout various stages of the lifespan. However, little is known about the impact of exercise on neurodevelopment during the adolescent years, particularly with regard to white matter microstructure, as assessed by diffusion tensor imaging (DTI). Both tract-based spatial statistics (TBSS) and tractography-based along-tract statistics were utilized to examine the relationship between white matter microstructure and aerobic exercise in adolescent males, ages 15-18. Furthermore, we examined the data by both (1) grouping individuals based on aerobic fitness self-reports (high fit (HF) vs. low fit (LF)), and (2) using VO2 peak as a continuous variable across the entire sample. Results showed that HF youth had an overall higher number of streamline counts compared to LF peers, which was driven by group differences in corticospinal tract (CST) and anterior corpus callosum (Fminor). In addition, VO2 peak was negatively related to FA in the left CST. Together, these results suggest that aerobic fitness relates to white matter connectivity and microstructure in tracts carrying frontal and motor fibers during adolescence. Furthermore, the current study highlights the importance of considering the environmental factor of aerobic exercise when examining adolescent brain development.",
keywords = "Adolescence, Aerobic exercise, Diffusion tensor imaging, Tractography, White matter",
author = "Herting, {Megan M.} and Colby, {John B.} and Sowell, {Elizabeth R.} and Bonnie Nagel",
year = "2014",
month = "1",
doi = "10.1016/j.dcn.2013.11.003",
language = "English (US)",
volume = "7",
pages = "65--75",
journal = "Developmental Cognitive Neuroscience",
issn = "1878-9293",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - White matter connectivity and aerobic fitness in male adolescents

AU - Herting, Megan M.

AU - Colby, John B.

AU - Sowell, Elizabeth R.

AU - Nagel, Bonnie

PY - 2014/1

Y1 - 2014/1

N2 - Exercise has been shown to have positive effects on the brain and behavior throughout various stages of the lifespan. However, little is known about the impact of exercise on neurodevelopment during the adolescent years, particularly with regard to white matter microstructure, as assessed by diffusion tensor imaging (DTI). Both tract-based spatial statistics (TBSS) and tractography-based along-tract statistics were utilized to examine the relationship between white matter microstructure and aerobic exercise in adolescent males, ages 15-18. Furthermore, we examined the data by both (1) grouping individuals based on aerobic fitness self-reports (high fit (HF) vs. low fit (LF)), and (2) using VO2 peak as a continuous variable across the entire sample. Results showed that HF youth had an overall higher number of streamline counts compared to LF peers, which was driven by group differences in corticospinal tract (CST) and anterior corpus callosum (Fminor). In addition, VO2 peak was negatively related to FA in the left CST. Together, these results suggest that aerobic fitness relates to white matter connectivity and microstructure in tracts carrying frontal and motor fibers during adolescence. Furthermore, the current study highlights the importance of considering the environmental factor of aerobic exercise when examining adolescent brain development.

AB - Exercise has been shown to have positive effects on the brain and behavior throughout various stages of the lifespan. However, little is known about the impact of exercise on neurodevelopment during the adolescent years, particularly with regard to white matter microstructure, as assessed by diffusion tensor imaging (DTI). Both tract-based spatial statistics (TBSS) and tractography-based along-tract statistics were utilized to examine the relationship between white matter microstructure and aerobic exercise in adolescent males, ages 15-18. Furthermore, we examined the data by both (1) grouping individuals based on aerobic fitness self-reports (high fit (HF) vs. low fit (LF)), and (2) using VO2 peak as a continuous variable across the entire sample. Results showed that HF youth had an overall higher number of streamline counts compared to LF peers, which was driven by group differences in corticospinal tract (CST) and anterior corpus callosum (Fminor). In addition, VO2 peak was negatively related to FA in the left CST. Together, these results suggest that aerobic fitness relates to white matter connectivity and microstructure in tracts carrying frontal and motor fibers during adolescence. Furthermore, the current study highlights the importance of considering the environmental factor of aerobic exercise when examining adolescent brain development.

KW - Adolescence

KW - Aerobic exercise

KW - Diffusion tensor imaging

KW - Tractography

KW - White matter

UR - http://www.scopus.com/inward/record.url?scp=84890490361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890490361&partnerID=8YFLogxK

U2 - 10.1016/j.dcn.2013.11.003

DO - 10.1016/j.dcn.2013.11.003

M3 - Article

VL - 7

SP - 65

EP - 75

JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

SN - 1878-9293

ER -