Wearable cardioverter-defibrillators in pediatric cardiomyopathy: A cost-utility analysis

Patrick D. Evers, Jeffrey B. Anderson, Thomas D. Ryan, Richard J. Czosek, Timothy K. Knilans, David S. Spar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. Patients with severe cardiac dysfunction are thought to be at risk of sudden cardiac arrest (SCA). After diagnosis, a period of medical optimization is recommended before permanent implantable cardioverter-defibrillator (ICD) implantation. Wearable cardioverter-defibrillators (WCDs) provide an option for arrhythmia protection as an outpatient during this optimization. Objective: The purpose of this study was to determine the strategy that optimizes cost and survival during medical optimization of a patient with DCM before ICD placement. Methods: A Markov state transition model was constructed for the 3 clinical approaches to compare costs, clinical outcomes, and quality of life: (1) “Inpatient,” (2) “Home-WCD,” and (3) “Home-No WCD.” Transitional probabilities, costs, and utility metrics were extracted from the existing literature. Cost-effectiveness was assessed comparing each paradigm's incremental cost-effectiveness ratio against a societal willingness-to-pay threshold of $50,000 per quality-adjusted life year. Results: The cost-utility analysis illustrated that Home-WCD met the willingness-to-pay threshold with an incremental cost-effectiveness ratio of $20,103 per quality-adjusted life year and 4 mortalities prevented per 100 patients as compared with Home-No WCD. One-way sensitivity analyses demonstrated that Home-No WCD became the most cost-effective solution when the probability of SCA fell below 0.2% per week, the probability of SCA survival with a WCD fell below 9.8%, or the probability of SCA survival with Home-No WCD quadrupled from base-case assumptions. Conclusion: Based on the existing literature probabilities of SCA in pediatric patients with DCM undergoing medical optimization before ICD implantation, sending a patient home with a WCD may be a cost-effective strategy.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalHeart Rhythm
Volume17
Issue number2
DOIs
StatePublished - Feb 2020
Externally publishedYes

Keywords

  • Arrhythmia
  • Cost-utility
  • Dilated cardiomyopathy
  • Pediatrics
  • Wearable cardioverter-defibrillators

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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