Walking in circles: Navigation deficits from Parkinson's disease but not from cerebellar ataxia

C. Paquette, E. Franzén, G. M. Jones, Fay Horak

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), eight subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalNeuroscience
Volume190
DOIs
StatePublished - Sep 5 2011

Fingerprint

Cerebellar Ataxia
Walking
Parkinson Disease
Basal Ganglia
Levodopa
Cerebellum
Healthy Volunteers
Control Groups

Keywords

  • Gait
  • Kinematics
  • Levodopa
  • Navigation
  • Task performance and analysis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Walking in circles : Navigation deficits from Parkinson's disease but not from cerebellar ataxia. / Paquette, C.; Franzén, E.; Jones, G. M.; Horak, Fay.

In: Neuroscience, Vol. 190, 05.09.2011, p. 177-183.

Research output: Contribution to journalArticle

Paquette, C. ; Franzén, E. ; Jones, G. M. ; Horak, Fay. / Walking in circles : Navigation deficits from Parkinson's disease but not from cerebellar ataxia. In: Neuroscience. 2011 ; Vol. 190. pp. 177-183.
@article{c690d17c65f4408f999ebc74c4216039,
title = "Walking in circles: Navigation deficits from Parkinson's disease but not from cerebellar ataxia",
abstract = "Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), eight subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.",
keywords = "Gait, Kinematics, Levodopa, Navigation, Task performance and analysis",
author = "C. Paquette and E. Franz{\'e}n and Jones, {G. M.} and Fay Horak",
year = "2011",
month = "9",
day = "5",
doi = "10.1016/j.neuroscience.2011.06.020",
language = "English (US)",
volume = "190",
pages = "177--183",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Walking in circles

T2 - Navigation deficits from Parkinson's disease but not from cerebellar ataxia

AU - Paquette, C.

AU - Franzén, E.

AU - Jones, G. M.

AU - Horak, Fay

PY - 2011/9/5

Y1 - 2011/9/5

N2 - Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), eight subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.

AB - Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), eight subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.

KW - Gait

KW - Kinematics

KW - Levodopa

KW - Navigation

KW - Task performance and analysis

UR - http://www.scopus.com/inward/record.url?scp=80051591960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051591960&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2011.06.020

DO - 10.1016/j.neuroscience.2011.06.020

M3 - Article

C2 - 21704129

AN - SCOPUS:80051591960

VL - 190

SP - 177

EP - 183

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -