Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography

Hrebesh M. Subhash, Viviana Davila, Hai Sun, Anh Nguyen-Huynh, Alfred Nuttall, Ruikang K. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Studying the inner ear microstructures and microvascular dynamics is extremely important to understand the cochlear function and to further advance the diagnosis, prevention and treatment of many otologic disorders. There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea and the micro vascular perfusion within it for both clinical as well as fundamental studies. In this study, we explored the feasibility of high-speed spectral domain optical coherence tomography (SD-OCT) and ultra-high sensitive optical microangiography (UHS-OMAG) for volumetric in vivo imaging of intracochlear microstructures and microvascular perfusion in mice, respectively.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7889
DOIs
StatePublished - 2011
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
CountryUnited States
CitySan Francisco, CA
Period1/24/111/26/11

Fingerprint

Optical tomography
Cochlea
Optical Coherence Tomography
mice
Perfusion
tomography
high speed
Imaging techniques
cochlea
microstructure
Microstructure
anatomy
ear
Inner Ear
Blood Vessels
Anatomy
disorders

Keywords

  • biomedical optical imaging
  • blood flow measurement
  • image processing
  • Optical coherence tomography
  • optical interferometry
  • optical microangiography
  • spectral interferometry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography. / Subhash, Hrebesh M.; Davila, Viviana; Sun, Hai; Nguyen-Huynh, Anh; Nuttall, Alfred; Wang, Ruikang K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7889 2011. 78892V.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Subhash, HM, Davila, V, Sun, H, Nguyen-Huynh, A, Nuttall, A & Wang, RK 2011, Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7889, 78892V, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, San Francisco, CA, United States, 1/24/11. https://doi.org/10.1117/12.874182
Subhash, Hrebesh M. ; Davila, Viviana ; Sun, Hai ; Nguyen-Huynh, Anh ; Nuttall, Alfred ; Wang, Ruikang K. / Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7889 2011.
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