TY - GEN
T1 - Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography
AU - Subhash, Hrebesh M.
AU - Davila, Viviana
AU - Sun, Hai
AU - Nguyen-Huynh, Anh T.
AU - Nuttall, Alfred L.
AU - Wang, Ruikang K.
PY - 2011
Y1 - 2011
N2 - Studying the inner ear microstructures and microvascular dynamics is extremely important to understand the cochlear function and to further advance the diagnosis, prevention and treatment of many otologic disorders. There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea and the micro vascular perfusion within it for both clinical as well as fundamental studies. In this study, we explored the feasibility of high-speed spectral domain optical coherence tomography (SD-OCT) and ultra-high sensitive optical microangiography (UHS-OMAG) for volumetric in vivo imaging of intracochlear microstructures and microvascular perfusion in mice, respectively.
AB - Studying the inner ear microstructures and microvascular dynamics is extremely important to understand the cochlear function and to further advance the diagnosis, prevention and treatment of many otologic disorders. There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea and the micro vascular perfusion within it for both clinical as well as fundamental studies. In this study, we explored the feasibility of high-speed spectral domain optical coherence tomography (SD-OCT) and ultra-high sensitive optical microangiography (UHS-OMAG) for volumetric in vivo imaging of intracochlear microstructures and microvascular perfusion in mice, respectively.
KW - Optical coherence tomography
KW - biomedical optical imaging
KW - blood flow measurement
KW - image processing
KW - optical interferometry
KW - optical microangiography
KW - spectral interferometry
UR - http://www.scopus.com/inward/record.url?scp=79953736593&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953736593&partnerID=8YFLogxK
U2 - 10.1117/12.874182
DO - 10.1117/12.874182
M3 - Conference contribution
AN - SCOPUS:79953736593
SN - 9780819484260
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
T2 - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
Y2 - 24 January 2011 through 26 January 2011
ER -