Vitamin E treatment for tardive dyskinesia

Lenard A. Adler, John Rotrosen, Robert Edson, Philip Lavori, James Lohr, Robert Hitzemann, Dennis Raisch, Michael Caligiuri, Kathlene Tracy

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Abstract

Background: Several short-term, controlled trials have documented the efficacy of vitamin E in treating tardive dyskinesia. However, the persistent nature of the disease prompted us to perform a multicenter, longer-term trial of vitamin E. Methods: The study was a prospective, randomized, 9-site trial of up to 2 years of treatment with d-vitamin E (1600 IU/d) vs matching placebo. One hundred fifty-eight subjects with tardive dyskinesia who were receiving neuroleptic medications were enrolled. The blinded assessments performed were clinical (Abnormal Involuntary Movements Scale, Barnes Akathisia Scale, and Modified Simpson-Angus [for Extrapyramidal Symptoms] Scale)and electromechanical assessments of movement disorders, psychiatric status (Brief Psychiatric Rating Scale), and functioning (Global Assessment of Functioning). There were no significant differences in baseline demographic characteristics or in study assessments between the group that received vitamin E and the group that received placebo. Results: Vitamin E was well tolerated and subject compliance with medication was good and similar between treatment groups. One hundred seven subjects (70% of those receiving vitamin E and 66% of subjects receiving placebo) completed at least 1 year of treatment. There were no significant effects of vitamin E on total scores or subscale scores for the AIMS, electromechanical measures of dyskinesia, or scores from the other 4 scales. Conclusion: This long-term, randomized trial of vitamin E vs placebo found no evidence for efficacy of vitamin E in the treatment of tardive dyskinesia.

Original languageEnglish (US)
Pages (from-to)836-841
Number of pages6
JournalArchives of General Psychiatry
Volume56
Issue number9
DOIs
StatePublished - Sep 1 1999

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ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Adler, L. A., Rotrosen, J., Edson, R., Lavori, P., Lohr, J., Hitzemann, R., Raisch, D., Caligiuri, M., & Tracy, K. (1999). Vitamin E treatment for tardive dyskinesia. Archives of General Psychiatry, 56(9), 836-841. https://doi.org/10.1001/archpsyc.56.9.836