Vitamin D deficiency in older men

Eric Orwoll, Carrie Nielson, Lynn Marshall, Lori Lambert, Kathleen F. Holton, Andrew R. Hoffman, Elizabeth Barrett-Connor, James M. Shikany, Tien Dam, Jane A. Cauley

Research output: Contribution to journalArticle

106 Scopus citations


Context: Vitamin D deficiency is not adequately evaluated in older men. Objective: The aim of the study was to determine the prevalence of vitamin D deficiency and identify risk factors for its occurrence. Design and Setting: We conducted a cross-sectional evaluation of 1606 older men in the general community who were enrolled in the Osteoporotic Fractures in Men Study. Participants: A randomly selected subcohort of a large population of men from six U.S. communities participated in the study. Main Outcome Measures: Serum concentrations of 25-hydroxyvitamin D 2 [25(OH)D 2] and 25(OH)D 3 were measured using mass spectrometry. Results: Deficiency [25(OH)D 80yrold, did not engage in lawn/garden work, and had a body mass index greater than 25 kg/m 2 and vitamin D intake below 400 IU/d, the prevalence of vitamin D deficiency was 86%. 25(OH)D 2 levels were present in a small fraction of men and accounted for a low proportion of total 25(OH)D levels. The use of vitamin D supplements was reported by 58% of men, but supplement use had a small effect on total 25(OH)D levels and, despite supplement use, low levels remained frequent. Conclusions: Vitamin D deficiency is common in older men and is especially prevalent in obese, sedentary men living at higher latitudes. Use of vitamin D supplements at levels reported here did not result in adequate vitamin D nutrition.

Original languageEnglish (US)
Pages (from-to)1214-1222
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Apr 2009


ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Orwoll, E., Nielson, C., Marshall, L., Lambert, L., Holton, K. F., Hoffman, A. R., Barrett-Connor, E., Shikany, J. M., Dam, T., & Cauley, J. A. (2009). Vitamin D deficiency in older men. Journal of Clinical Endocrinology and Metabolism, 94(4), 1214-1222.