Vitamin D deficiency in older men

Eric Orwoll, Carrie Nielson, Lynn Marshall, Lori Lambert, Kathleen F. Holton, Andrew R. Hoffman, Elizabeth Barrett-Connor, James M. Shikany, Tien Dam, Jane A. Cauley

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Context: Vitamin D deficiency is not adequately evaluated in older men. Objective: The aim of the study was to determine the prevalence of vitamin D deficiency and identify risk factors for its occurrence. Design and Setting: We conducted a cross-sectional evaluation of 1606 older men in the general community who were enrolled in the Osteoporotic Fractures in Men Study. Participants: A randomly selected subcohort of a large population of men from six U.S. communities participated in the study. Main Outcome Measures: Serum concentrations of 25-hydroxyvitamin D 2 [25(OH)D 2] and 25(OH)D 3 were measured using mass spectrometry. Results: Deficiency [25(OH)D 80yrold, did not engage in lawn/garden work, and had a body mass index greater than 25 kg/m 2 and vitamin D intake below 400 IU/d, the prevalence of vitamin D deficiency was 86%. 25(OH)D 2 levels were present in a small fraction of men and accounted for a low proportion of total 25(OH)D levels. The use of vitamin D supplements was reported by 58% of men, but supplement use had a small effect on total 25(OH)D levels and, despite supplement use, low levels remained frequent. Conclusions: Vitamin D deficiency is common in older men and is especially prevalent in obese, sedentary men living at higher latitudes. Use of vitamin D supplements at levels reported here did not result in adequate vitamin D nutrition.

Original languageEnglish (US)
Pages (from-to)1214-1222
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number4
DOIs
StatePublished - Apr 2009

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Vitamin D Deficiency
Vitamin D
25-Hydroxyvitamin D 2
Ergocalciferols
Osteoporotic Fractures
Nutrition
Mass spectrometry
Mass Spectrometry
Body Mass Index
Outcome Assessment (Health Care)
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Vitamin D deficiency in older men. / Orwoll, Eric; Nielson, Carrie; Marshall, Lynn; Lambert, Lori; Holton, Kathleen F.; Hoffman, Andrew R.; Barrett-Connor, Elizabeth; Shikany, James M.; Dam, Tien; Cauley, Jane A.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 4, 04.2009, p. 1214-1222.

Research output: Contribution to journalArticle

Orwoll, E, Nielson, C, Marshall, L, Lambert, L, Holton, KF, Hoffman, AR, Barrett-Connor, E, Shikany, JM, Dam, T & Cauley, JA 2009, 'Vitamin D deficiency in older men', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 4, pp. 1214-1222. https://doi.org/10.1210/jc.2008-1784
Orwoll, Eric ; Nielson, Carrie ; Marshall, Lynn ; Lambert, Lori ; Holton, Kathleen F. ; Hoffman, Andrew R. ; Barrett-Connor, Elizabeth ; Shikany, James M. ; Dam, Tien ; Cauley, Jane A. / Vitamin D deficiency in older men. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 4. pp. 1214-1222.
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