Virus-induced asthma attacks

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Viral infections are responsible for the majority of asthma attacks in both children and adults. Vagally mediated reflex bronchoconstriction is potentiated due to loss of function of inhibitory M2 muscarinic receptors on the airway parasympathetic nerves. Multiple mechanisms are involved. Production of interferons may down regulate the expression of the M2 receptor gene. This effect is reversed by steroids. In allergic animals (and perhaps in atopic humans) eosinophils are recruited to the airway nerves, where they are activated, releasing major basic protein, which binds to the M2 receptors, blocking their function. Despite these negative physiological consequences of eosinophil activation, eosinophils are capable of exerting a potent antiviral effect. Thus, the inflammatory response to viral infections may have positive, as well as negative, consequences.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalJournal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
Volume17
Issue number2
DOIs
StatePublished - 2004

Fingerprint

Eosinophils
Asthma
Virus Diseases
Viruses
Muscarinic M2 Receptors
Bronchoconstriction
Interferons
Antiviral Agents
Reflex
Down-Regulation
Steroids
Genes
Proteins

Keywords

  • Gene expression
  • Lung
  • Parainfluenza
  • Vagus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Virus-induced asthma attacks. / Jacoby, David.

In: Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung, Vol. 17, No. 2, 2004, p. 169-173.

Research output: Contribution to journalArticle

@article{dcd24be2ee8242ffa3d1edf693617145,
title = "Virus-induced asthma attacks",
abstract = "Viral infections are responsible for the majority of asthma attacks in both children and adults. Vagally mediated reflex bronchoconstriction is potentiated due to loss of function of inhibitory M2 muscarinic receptors on the airway parasympathetic nerves. Multiple mechanisms are involved. Production of interferons may down regulate the expression of the M2 receptor gene. This effect is reversed by steroids. In allergic animals (and perhaps in atopic humans) eosinophils are recruited to the airway nerves, where they are activated, releasing major basic protein, which binds to the M2 receptors, blocking their function. Despite these negative physiological consequences of eosinophil activation, eosinophils are capable of exerting a potent antiviral effect. Thus, the inflammatory response to viral infections may have positive, as well as negative, consequences.",
keywords = "Gene expression, Lung, Parainfluenza, Vagus",
author = "David Jacoby",
year = "2004",
doi = "10.1089/0894268041457156",
language = "English (US)",
volume = "17",
pages = "169--173",
journal = "Journal of Aerosol Medicine and Pulmonary Drug Delivery",
issn = "1941-2711",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

TY - JOUR

T1 - Virus-induced asthma attacks

AU - Jacoby, David

PY - 2004

Y1 - 2004

N2 - Viral infections are responsible for the majority of asthma attacks in both children and adults. Vagally mediated reflex bronchoconstriction is potentiated due to loss of function of inhibitory M2 muscarinic receptors on the airway parasympathetic nerves. Multiple mechanisms are involved. Production of interferons may down regulate the expression of the M2 receptor gene. This effect is reversed by steroids. In allergic animals (and perhaps in atopic humans) eosinophils are recruited to the airway nerves, where they are activated, releasing major basic protein, which binds to the M2 receptors, blocking their function. Despite these negative physiological consequences of eosinophil activation, eosinophils are capable of exerting a potent antiviral effect. Thus, the inflammatory response to viral infections may have positive, as well as negative, consequences.

AB - Viral infections are responsible for the majority of asthma attacks in both children and adults. Vagally mediated reflex bronchoconstriction is potentiated due to loss of function of inhibitory M2 muscarinic receptors on the airway parasympathetic nerves. Multiple mechanisms are involved. Production of interferons may down regulate the expression of the M2 receptor gene. This effect is reversed by steroids. In allergic animals (and perhaps in atopic humans) eosinophils are recruited to the airway nerves, where they are activated, releasing major basic protein, which binds to the M2 receptors, blocking their function. Despite these negative physiological consequences of eosinophil activation, eosinophils are capable of exerting a potent antiviral effect. Thus, the inflammatory response to viral infections may have positive, as well as negative, consequences.

KW - Gene expression

KW - Lung

KW - Parainfluenza

KW - Vagus

UR - http://www.scopus.com/inward/record.url?scp=3242660664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242660664&partnerID=8YFLogxK

U2 - 10.1089/0894268041457156

DO - 10.1089/0894268041457156

M3 - Article

C2 - 15294068

AN - SCOPUS:3242660664

VL - 17

SP - 169

EP - 173

JO - Journal of Aerosol Medicine and Pulmonary Drug Delivery

JF - Journal of Aerosol Medicine and Pulmonary Drug Delivery

SN - 1941-2711

IS - 2

ER -