@article{c3d4fc2ac6c64598b76ba99397c8b58e,
title = "Virologic characterization of multidrug-resistant cytomegalovirus infection in 2 transplant recipients treated With maribavir",
abstract = "The experimental cytomegalovirus UL97 kinase inhibitor maribavir was used to treat 2 cases of infection in which viral mutations that conferred ganciclovir and foscarnet resistance had evolved sequentially. In one case, viral shedding was cleared without evidence of maribavir resistance in an isolate obtained after therapy. In the other case, a high-grade viremia was initially reduced 50-fold but rebounded 2 months later, coincident with the emergence of viral UL97 mutations T409M and H411Y, which confer maribavir resistance. The relatively rapid onset of maribavir resistance probably resulted from incomplete viral suppression in an immunosuppressed host with a high viral load.",
author = "Lynns Strasfeld and Ingi Lee and Walter Tatarowicz and Stephen Villano and Sunwen Chou",
note = "Funding Information: Received 10 December 2009; accepted 21 January 2010; electronically published 26 May 2010. Potential conflicts of interest: L.S. is a ViroPharma Clinical Trial Investigator; W.T. and S.V. are employees of ViroPharma; I.L.: no conflict. Financial support: Department of Veterans Affairs, ViroPharma–Department of Veterans Affairs Cooperative and Research Development Agreement ( L.S. and S.C.). Presented in part: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, California, September 2009 (abstract V-1256). Reprints or correspondence: Dr Sunwen Chou, VA Medical Ctr P3ID, 3710 SW US Veterans Hospital Rd, Portland, OR 97239 (chous@ohsu.edu).",
year = "2010",
month = jul,
day = "1",
doi = "10.1086/653122",
language = "English (US)",
volume = "202",
pages = "104--108",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",
}