@article{d71d896083854054ac1f8bb2c8538d48,
title = "Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS)",
abstract = "Introduction: The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by the National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance in dementia and mild cognitive impairment due to Alzheimer Disease. This paper describes a revision, the UDSNB 3.0. Methods: The Neuropsychology Work Group of the NIA Clinical Task Force recommended revisions through a process of due diligence to address shortcomings of the original battery. The UDSNB 3.0 covers episodic memory, processing speed, executive function, language, and constructional ability. Data from 3602 cognitively normal participants in the National Alzheimer Coordinating Center database were analyzed. Results: Descriptive statistics are presented. Multivariable linear regression analyses demonstrated score differences by age, sex, and education and were also used to create a normative calculator available online. Discussion: The UDSNB 3.0 neuropsychological battery provides a valuable non proprietary resource for conducting research on cognitive aging and dementia.",
keywords = "UDS, cognition, dementia, neuropsychological test",
author = "Sandra Weintraub and Lilah Besser and Dodge, {Hiroko H.} and Merilee Teylan and Steven Ferris and Goldstein, {Felicia C.} and Bruno Giordani and Joel Kramer and David Loewenstein and Dan Marson and Dan Mungas and David Salmon and Kathleen Welsh-Bohmer and Zhou, {Xiao Hua} and Shirk, {Steven D.} and Alireza Atri and Kukull, {Walter A.} and Creighton Phelps and Morris, {John C.}",
note = "Funding Information: S.W.: is participating in clinical trials of antidementia drugs from Eli Lilly and Company. K.W.-B.: received honoraria from Merck, Roche,T3D, Diffusion, and Biogen Companies. K.W.-B. is currently receiving funding from Takeda Pharmaceutical Company in her role as the Neuro-psychology Lead for the TOMMORROW clinical trial program. D.M.: serves as a consultant for Janssen. Neither J.C.M. nor his family owns stock or has equity interest (outside of mutual funds or other externally directed accounts) in any pharmaceutical or biotechnology company. J.C.M. is currently participating in clinical trials of antidementia drugs from Eli Lilly and Company, Biogen, and Janssen. J.C.M. serves as a consultant for Lilly USA. He receives research support from Eli Lilly/Avid Radiopharmaceuticals and is funded by NIH grants #P50 AG005681; P01AG003991; P01AG026276; and UF01AG032438. The remaining authors declare no conflicts of interest. Funding Information: The Uniform Data Set Neuropsychology Work Group dedicates this paper to the memory of Dr Steven Ferris, who passed away on April 5, 2017. He was a cherished and highly respected member of our community who made major contributions to the creation of the UDS and to the work that went into this publication. We all mourn his loss. The Uniform Data Set Neuropsychology Work Group wishes to thank the following individuals for giving their permission to include tests they created in the UDSNB 3.0: Zaid Nasreddine, MD (MoCA); Suzanne Craft, PhD ({"}Craft Story{"} and scoring method); Andrew Saykin, PhD for providing data on the equivalence of forms of the Craft Story to Logical Memory; Tamar Gollan, PhD for the MINT; Joel Kramer for providing alternate number strings for the number span test; and Kate Possin and Joel Kramer for the Benson complex figure test. We also wish to thank Nina Silverberg, PhD, for her insightful leadership throughout the conduct of this project. The NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA-funded ADCs: P30 AG019610 (PI Eric Reiman, MD), P30 AG013846 (PI Neil Kowall, MD), P50 AG008702 (PI Scott Small, MD), P50 AG025688 (PI Allan Levey,MD, PhD), P50 AG047266 (PI Todd Golde, MD, PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn Albert, PhD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG016574 (PI Ronald Petersen, MD, PhD), P50 AG005138 (PI Mary Sano, PhD), P30 AG008051 (PI Thomas Wisniewski, MD), P30 AG013854 (PI M. Marsel Mesulam, MD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P50 AG047366 (PI Victor Henderson, MD, MS), P30 AG010129 (PI Charles DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG005131 (PI James Brewer, MD, PhD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982 (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD), P30 AG053760 (PI Henry Paulson, MD, PhD), P30 AG010124 (PI John Trojanowski, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005142 (PI Helena Chui,MD), P30 AG012300 (PI Roger Rosenberg,MD), P30 AG049638 (PI Suzanne Craft, PhD), P50 AG005136 (PI Thomas Grabowski, MD), P50 AG033514 (PI Sanjay Asthana,MD, FRCP), P50 AG005681 (PI JohnMorris,MD), P50 AG047270 (PI Stephen Strittmatter, MD, PhD). S.W.: is participating in clinical trials of antidementia drugs from Eli Lilly and Company. K.W.-B.: received honoraria from Merck, Roche,T3D, Diffusion, and Biogen Companies. K.W.-B. is currently receiving funding from Takeda Pharmaceutical Company in her role as the Neuropsychology Lead for the TOMMORROW clinical trial program. D.M.: serves as a consultant for Janssen. Neither J.C.M. nor his family owns stock or has equity interest (outside of mutual funds or other externally directed accounts) in any pharmaceutical or biotechnology company. J.C.M. is currently participating in clinical trials of antidementia drugs from Eli Lilly and Company, Biogen, and Janssen. J.C.M. serves as a consultant for Lilly USA. He receives research support from Eli Lilly/Avid Radiopharmaceuticals and is funded by NIH grants #P50 AG005681; P01AG003991; P01AG026276; and UF01AG032438. Funding Information: The NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA-funded ADCs: P30 AG019610 (PI Eric Reiman, MD), P30 AG013846 (PI Neil Kowall, MD), P50 AG008702 (PI Scott Small, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P50 AG047266 (PI Todd Golde, MD, PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn Albert, PhD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG016574 (PI Ronald Petersen, MD, PhD), P50 AG005138 (PI Mary Sano, PhD), P30 AG008051 (PI Thomas Wisniewski, MD), P30 AG013854 (PI M. Marsel Mesulam, MD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P50 AG047366 (PI Victor Henderson, MD, MS), P30 AG010129 (PI Charles DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG005131 (PI James Brewer, MD, PhD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982 (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD), P30 AG053760 (PI Henry Paulson, MD, PhD), P30 AG010124 (PI John Trojanowski, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005142 (PI Helena Chui, MD), P30 AG012300 (PI Roger Rosenberg, MD), P30 AG049638 (PI Suzanne Craft, PhD), P50 AG005136 (PI Thomas Grabowski, MD), P50 AG033514 (PI Sanjay Asthana, MD, FRCP), P50 AG005681 (PI John Morris, MD), P50 AG047270 (PI Stephen Strittmatter, MD, PhD). Publisher Copyright: {\textcopyright} 2017 The Author(s). Published by Wolters Kluwer Health, Inc.",
year = "2018",
doi = "10.1097/WAD.0000000000000223",
language = "English (US)",
volume = "32",
pages = "10--17",
journal = "Alzheimer Disease and Associated Disorders",
issn = "0893-0341",
publisher = "Lippincott Williams and Wilkins",
number = "1",
}