Vasopressin deficiency abolishes a sexually dimorphic behavior in Brattleboro rats

M. D. Brot, I. L. Bernstein, Daniel Dorsa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The role of vasopressin (VP) in a sexually dimorphic behavior, the extinction of a conditioned taste aversion, was investigated in male and female rats of three different genotypes. This behavior was examined with a two bottle test in the wild-type Long-Evans (LE) rats, and then in partially VP deficient heterozygous (HET-BB) and completely VP deficient homozygous (HO-BB) Brattleboro rats. In Experiment 1, non-deprived male and female LE rats were given aversions to a sucrose solution by pairing it with a LiCl injection. The rate of extinction of the aversion upon reexposure to ad lib sucrose solution was examined and observed to be sexually dimorphic. Female LE rats extinguished at a significantly more rapid rate than males. Experiment 2 compared HET-BB and HO-BB male and female rats using the same paradigm. Neither of these VP-deficient groups showed sexual dimorphism of the extinction behavior. The data suggest that intact VP levels are necessary to observe the expression of this sexually dimorphic behavior.

Original languageEnglish (US)
Pages (from-to)839-843
Number of pages5
JournalPhysiology and Behavior
Volume51
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Brattleboro Rats
Neurogenic Diabetes Insipidus
Vasopressins
Long Evans Rats
Sucrose
Inbred BB Rats
Sex Characteristics
Genotype
Injections
Psychological Extinction

Keywords

  • Brattleboro rats
  • Conditioned taste aversion
  • Diabetes insipidus
  • Extinction
  • Sex differences
  • Sexual dimorphism
  • Testosterone
  • Vasopressin

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Vasopressin deficiency abolishes a sexually dimorphic behavior in Brattleboro rats. / Brot, M. D.; Bernstein, I. L.; Dorsa, Daniel.

In: Physiology and Behavior, Vol. 51, No. 4, 1992, p. 839-843.

Research output: Contribution to journalArticle

@article{017f121782a746c786ab61d3baa349c4,
title = "Vasopressin deficiency abolishes a sexually dimorphic behavior in Brattleboro rats",
abstract = "The role of vasopressin (VP) in a sexually dimorphic behavior, the extinction of a conditioned taste aversion, was investigated in male and female rats of three different genotypes. This behavior was examined with a two bottle test in the wild-type Long-Evans (LE) rats, and then in partially VP deficient heterozygous (HET-BB) and completely VP deficient homozygous (HO-BB) Brattleboro rats. In Experiment 1, non-deprived male and female LE rats were given aversions to a sucrose solution by pairing it with a LiCl injection. The rate of extinction of the aversion upon reexposure to ad lib sucrose solution was examined and observed to be sexually dimorphic. Female LE rats extinguished at a significantly more rapid rate than males. Experiment 2 compared HET-BB and HO-BB male and female rats using the same paradigm. Neither of these VP-deficient groups showed sexual dimorphism of the extinction behavior. The data suggest that intact VP levels are necessary to observe the expression of this sexually dimorphic behavior.",
keywords = "Brattleboro rats, Conditioned taste aversion, Diabetes insipidus, Extinction, Sex differences, Sexual dimorphism, Testosterone, Vasopressin",
author = "Brot, {M. D.} and Bernstein, {I. L.} and Daniel Dorsa",
year = "1992",
doi = "10.1016/0031-9384(92)90124-K",
language = "English (US)",
volume = "51",
pages = "839--843",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Vasopressin deficiency abolishes a sexually dimorphic behavior in Brattleboro rats

AU - Brot, M. D.

AU - Bernstein, I. L.

AU - Dorsa, Daniel

PY - 1992

Y1 - 1992

N2 - The role of vasopressin (VP) in a sexually dimorphic behavior, the extinction of a conditioned taste aversion, was investigated in male and female rats of three different genotypes. This behavior was examined with a two bottle test in the wild-type Long-Evans (LE) rats, and then in partially VP deficient heterozygous (HET-BB) and completely VP deficient homozygous (HO-BB) Brattleboro rats. In Experiment 1, non-deprived male and female LE rats were given aversions to a sucrose solution by pairing it with a LiCl injection. The rate of extinction of the aversion upon reexposure to ad lib sucrose solution was examined and observed to be sexually dimorphic. Female LE rats extinguished at a significantly more rapid rate than males. Experiment 2 compared HET-BB and HO-BB male and female rats using the same paradigm. Neither of these VP-deficient groups showed sexual dimorphism of the extinction behavior. The data suggest that intact VP levels are necessary to observe the expression of this sexually dimorphic behavior.

AB - The role of vasopressin (VP) in a sexually dimorphic behavior, the extinction of a conditioned taste aversion, was investigated in male and female rats of three different genotypes. This behavior was examined with a two bottle test in the wild-type Long-Evans (LE) rats, and then in partially VP deficient heterozygous (HET-BB) and completely VP deficient homozygous (HO-BB) Brattleboro rats. In Experiment 1, non-deprived male and female LE rats were given aversions to a sucrose solution by pairing it with a LiCl injection. The rate of extinction of the aversion upon reexposure to ad lib sucrose solution was examined and observed to be sexually dimorphic. Female LE rats extinguished at a significantly more rapid rate than males. Experiment 2 compared HET-BB and HO-BB male and female rats using the same paradigm. Neither of these VP-deficient groups showed sexual dimorphism of the extinction behavior. The data suggest that intact VP levels are necessary to observe the expression of this sexually dimorphic behavior.

KW - Brattleboro rats

KW - Conditioned taste aversion

KW - Diabetes insipidus

KW - Extinction

KW - Sex differences

KW - Sexual dimorphism

KW - Testosterone

KW - Vasopressin

UR - http://www.scopus.com/inward/record.url?scp=0026535909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026535909&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(92)90124-K

DO - 10.1016/0031-9384(92)90124-K

M3 - Article

C2 - 1594683

AN - SCOPUS:0026535909

VL - 51

SP - 839

EP - 843

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 4

ER -