Vasodilators in the canine mesenteric circulation

Evaluation of a potential aid in the diagnosis of gastrointestinal bleeding

M. Sovak, Josef Rosch, R. C. Lakin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Radiodiagnostic potential of intra-arterially injected vasodilating agents was investigated by their effects on total and segmenal resistances (VR) of mesenteric vasculature, blood flow in superior mesenteric artery and its bleeding branch; heart rate and ventricular and systemic blood pressure. Dipyridamole, isox-suprine, prochlorperazine, lidocaine, meglumine diatrizoate and carbon dioxide were poor dilators. Phentolamine produced hypotension; glucagon and serpasil an extremely long dilation. A large and short vasodilation was produced with tolazoline and nylidrin, but both agents increased VR of the postcapillary segment and caused transient hypotension and arrhythmias, nylidrin’s side effects were smaller. Oxygen produced large and long vasodilation and minimal systemic effects. It is concluded that oxygen or possibly nylidrin are suitable agents should an intermittently bleeding mesenteric artery be dilated for diagnostic purposes prior to angiography.

Original languageEnglish (US)
Pages (from-to)595-607
Number of pages13
JournalInvestigative Radiology
Volume10
Issue number6
StatePublished - 1975

Fingerprint

Nylidrin
Splanchnic Circulation
Vasodilator Agents
Canidae
Hemorrhage
Vasodilation
Hypotension
Prochlorperazine
Tolazoline
Diatrizoate Meglumine
Oxygen
Mesenteric Arteries
Superior Mesenteric Artery
Dipyridamole
Phentolamine
Reserpine
Lidocaine
Glucagon
Carbon Dioxide
Cardiac Arrhythmias

Keywords

  • Angiography
  • Contrast media
  • Gastrointestinal hemorrhage
  • Intra-arterial oxygen
  • Nylidrin
  • Tolazoline
  • Vasodilators

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Vasodilators in the canine mesenteric circulation : Evaluation of a potential aid in the diagnosis of gastrointestinal bleeding. / Sovak, M.; Rosch, Josef; Lakin, R. C.

In: Investigative Radiology, Vol. 10, No. 6, 1975, p. 595-607.

Research output: Contribution to journalArticle

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