Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Malika Aid, Kathleen Busman-Sahay, Samuel J. Vidal, Zoltan Maliga, Stephen Bondoc, Carly Starke, Margaret Terry, Connor A. Jacobson, Linda Wrijil, Sarah Ducat, Olga R. Brook, Andrew D. Miller, Maciel Porto, Kathryn L. Pellegrini, Maria Pino, Timothy N. Hoang, Abishek Chandrashekar, Shivani Patel, Kathryn Stephenson, Steven E. BosingerHanne Andersen, Mark G. Lewis, Jonathan L. Hecht, Peter K. Sorger, Amanda J. Martinot, Jacob D. Estes, Dan H. Barouch

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macrophage, cytokine, and thrombosis cascades.

Original languageEnglish (US)
Pages (from-to)1354-1366.e13
JournalCell
Volume183
Issue number5
DOIs
StatePublished - Nov 25 2020

Keywords

  • IFNα
  • SARS-CoV-2
  • coagulation
  • collagen
  • complement
  • macrophage
  • platelet
  • thrombosis
  • vWF
  • vascular

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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