Vascular Cell Physiology Under Shear Flow: Role of Cell Mechanics and Mechanotransduction

Devon Scott, Wei Tan, Jerry S.H. Lee, Owen McCarty, Monica T. Hinds

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Whether examined at the micro- or macroscale, biological phenomenona are not exempt from physical laws and principles. The vasculature is frequently utilized as a model system to better understand and analyze the consequences of biophysical forces on biochemical processes and ultimate biological phenotypes. Given the complexities of biological systems, there is an inherent need to focus in order to properly elucidate mechanisms. Mechanotransduction and cell mechanics in various stages of angiogenesis have long been examined at distinct length-scales ranging from subcellular, cellular, multi-cellular, tissue, and beyond. This chapter will highlight research over the past decades that have contributed to revealing the importance and interplay between biophysical forces (compressive and shear flow) and biological behavior (motility, regulation of smooth muscle cells, polarity). Abnormal biophysical forces, such as hypertension, contribute significantly to vascular diseases, including atherosclerosis and aneurysm formation. Understanding the relationship between biophysical forces and biological behavior is required to understand the mechanisms of vascular disease.

Original languageEnglish (US)
Title of host publicationStudies in Mechanobiology, Tissue Engineering and Biomaterials
PublisherSpringer
Pages121-141
Number of pages21
DOIs
StatePublished - 2013

Publication series

NameStudies in Mechanobiology, Tissue Engineering and Biomaterials
Volume12
ISSN (Print)1868-2006
ISSN (Electronic)1868-2014

Keywords

  • Arterial Stiffness
  • Focal Adhesion
  • Pulmonary Hypertension
  • Pulsatile Flow
  • Pulse Pressure

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanics of Materials
  • Biomaterials
  • Biotechnology
  • Biophysics
  • Medicine (miscellaneous)

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  • Cite this

    Scott, D., Tan, W., Lee, J. S. H., McCarty, O., & Hinds, M. T. (2013). Vascular Cell Physiology Under Shear Flow: Role of Cell Mechanics and Mechanotransduction. In Studies in Mechanobiology, Tissue Engineering and Biomaterials (pp. 121-141). (Studies in Mechanobiology, Tissue Engineering and Biomaterials; Vol. 12). Springer. https://doi.org/10.1007/978-3-642-30856-7_6