Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)

S. Chinn, P. Burney, D. Jarvis, C. Luczynska, E. Lai, P. Burney, S. Chinn, C. Luczynska, D. Jarvis, P. Vermeire, H. Kesteloot, J. Bousquet, J. Bousquet, J. Knani, D. Nowak, H. Magnussen, J. Prichard, S. Allwright, D. MacLeod, R. de Marco & 75 others R. de Marco Lo Cascio, C. Campello, B. Rijcken, J. M. Antó, J. Sunyer, F. Burgos, J. Castellsagué, J. Roca, J. B. Soriano, A. Tobías, J. Alves, J. A. Marques, G. Boman, C. Janson, E. Björnsson, N. Nielsen, P. Paoletti, W. Popp, M. Abramson, J. Kutin, P. Vermeire, F. van Bastelaer, F. Neukirch, R. Liard, I. Pin, C. Pison, A. Taytard, H. E. Wichmann, J. Heinrich, N. Papageorgiou, P. Avarlis, M. Gaga, C. Marossis, T. Gislason, D. Gislason, M. Bugiani, C. Bucca, C. Romano, A. Marinoni, T. Cerveri, L. Casali, A. Kremer, J. Crane, S. Lewis, A. Gulsvik, E. Omenaas, N. Muniozguren, J. Ramos González, A. Capelastegui, J. Castillo, J. Rodriguez Portal, J. Martinez-Moratalla, E. Almar, J. Maldonado Pérez, A. Pereira, J. Sánchez, J. Quiros, I. Huerta, F. Pavo, L. Rosenhall, E. Norrman, B. Lundbäck, N. Lindholm, P. Plaschke, U. Ackermann-Liebrich, N. Künzli, A. Perruchoud, M. Burr, J. Layzell, R. Hall, B. Harrison, J. Stark, A (Sonia) Buist, W. Vollmer, Molly Osborne

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge delivered by Mefar dosimeter according to a standardized protocol used in 35 centres in 16 countries. Data were obtained from 13,161 men and women, aged 20-44 yrs at the start of the study. The dose of methacholine producing a 20% fall in forced expiratory volume in one second (FEV1) (PD20) and the regression coefficient of percentage decline in FEV1 with log dose, were calculated ('slope', after transformation), with and without calibration of nebulizers by weight and adjustment for nonresponsc bias. Standardization for baseline lung function and variation in smoking prevalence was applied to slope. Results were robust to whichever summary measure was used, and to the various adjustments. Responsiveness was low in Iceland and Switzerland, and in most centres in Sweden, Italy and Spain, and high in New Zealand, Australia, the USA, Britain, France, Denmark and Germany. Bronchial responsiveness varies considerably in Europe, and high levels are not confined to the English-speaking world.

Original languageEnglish (US)
Pages (from-to)2495-2501
Number of pages7
JournalEuropean Respiratory Journal
Volume10
Issue number11
DOIs
StatePublished - Nov 1997
Externally publishedYes

Fingerprint

Methacholine Chloride
European Union
Health Surveys
Social Adjustment
Iceland
Nebulizers and Vaporizers
Forced Expiratory Volume
Denmark
Switzerland
New Zealand
Sweden
Spain
Italy
Calibration
France
Germany
Smoking
Pharmacology
Weights and Measures
Lung

Keywords

  • Bronchial provocation tests
  • Epidemiology
  • Methacholine
  • Multi-centre study

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS). / Chinn, S.; Burney, P.; Jarvis, D.; Luczynska, C.; Lai, E.; Burney, P.; Chinn, S.; Luczynska, C.; Jarvis, D.; Vermeire, P.; Kesteloot, H.; Bousquet, J.; Bousquet, J.; Knani, J.; Nowak, D.; Magnussen, H.; Prichard, J.; Allwright, S.; MacLeod, D.; de Marco, R.; Lo Cascio, R. de Marco; Campello, C.; Rijcken, B.; Antó, J. M.; Sunyer, J.; Burgos, F.; Castellsagué, J.; Roca, J.; Soriano, J. B.; Tobías, A.; Alves, J.; Marques, J. A.; Boman, G.; Janson, C.; Björnsson, E.; Nielsen, N.; Paoletti, P.; Popp, W.; Abramson, M.; Kutin, J.; Vermeire, P.; van Bastelaer, F.; Neukirch, F.; Liard, R.; Pin, I.; Pison, C.; Taytard, A.; Wichmann, H. E.; Heinrich, J.; Papageorgiou, N.; Avarlis, P.; Gaga, M.; Marossis, C.; Gislason, T.; Gislason, D.; Bugiani, M.; Bucca, C.; Romano, C.; Marinoni, A.; Cerveri, T.; Casali, L.; Kremer, A.; Crane, J.; Lewis, S.; Gulsvik, A.; Omenaas, E.; Muniozguren, N.; Ramos González, J.; Capelastegui, A.; Castillo, J.; Rodriguez Portal, J.; Martinez-Moratalla, J.; Almar, E.; Maldonado Pérez, J.; Pereira, A.; Sánchez, J.; Quiros, J.; Huerta, I.; Pavo, F.; Rosenhall, L.; Norrman, E.; Lundbäck, B.; Lindholm, N.; Plaschke, P.; Ackermann-Liebrich, U.; Künzli, N.; Perruchoud, A.; Burr, M.; Layzell, J.; Hall, R.; Harrison, B.; Stark, J.; Buist, A (Sonia); Vollmer, W.; Osborne, Molly.

In: European Respiratory Journal, Vol. 10, No. 11, 11.1997, p. 2495-2501.

Research output: Contribution to journalArticle

Chinn, S, Burney, P, Jarvis, D, Luczynska, C, Lai, E, Burney, P, Chinn, S, Luczynska, C, Jarvis, D, Vermeire, P, Kesteloot, H, Bousquet, J, Bousquet, J, Knani, J, Nowak, D, Magnussen, H, Prichard, J, Allwright, S, MacLeod, D, de Marco, R, Lo Cascio, RDM, Campello, C, Rijcken, B, Antó, JM, Sunyer, J, Burgos, F, Castellsagué, J, Roca, J, Soriano, JB, Tobías, A, Alves, J, Marques, JA, Boman, G, Janson, C, Björnsson, E, Nielsen, N, Paoletti, P, Popp, W, Abramson, M, Kutin, J, Vermeire, P, van Bastelaer, F, Neukirch, F, Liard, R, Pin, I, Pison, C, Taytard, A, Wichmann, HE, Heinrich, J, Papageorgiou, N, Avarlis, P, Gaga, M, Marossis, C, Gislason, T, Gislason, D, Bugiani, M, Bucca, C, Romano, C, Marinoni, A, Cerveri, T, Casali, L, Kremer, A, Crane, J, Lewis, S, Gulsvik, A, Omenaas, E, Muniozguren, N, Ramos González, J, Capelastegui, A, Castillo, J, Rodriguez Portal, J, Martinez-Moratalla, J, Almar, E, Maldonado Pérez, J, Pereira, A, Sánchez, J, Quiros, J, Huerta, I, Pavo, F, Rosenhall, L, Norrman, E, Lundbäck, B, Lindholm, N, Plaschke, P, Ackermann-Liebrich, U, Künzli, N, Perruchoud, A, Burr, M, Layzell, J, Hall, R, Harrison, B, Stark, J, Buist, AS, Vollmer, W & Osborne, M 1997, 'Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)', European Respiratory Journal, vol. 10, no. 11, pp. 2495-2501. https://doi.org/10.1183/09031936.97.10112495
Chinn, S. ; Burney, P. ; Jarvis, D. ; Luczynska, C. ; Lai, E. ; Burney, P. ; Chinn, S. ; Luczynska, C. ; Jarvis, D. ; Vermeire, P. ; Kesteloot, H. ; Bousquet, J. ; Bousquet, J. ; Knani, J. ; Nowak, D. ; Magnussen, H. ; Prichard, J. ; Allwright, S. ; MacLeod, D. ; de Marco, R. ; Lo Cascio, R. de Marco ; Campello, C. ; Rijcken, B. ; Antó, J. M. ; Sunyer, J. ; Burgos, F. ; Castellsagué, J. ; Roca, J. ; Soriano, J. B. ; Tobías, A. ; Alves, J. ; Marques, J. A. ; Boman, G. ; Janson, C. ; Björnsson, E. ; Nielsen, N. ; Paoletti, P. ; Popp, W. ; Abramson, M. ; Kutin, J. ; Vermeire, P. ; van Bastelaer, F. ; Neukirch, F. ; Liard, R. ; Pin, I. ; Pison, C. ; Taytard, A. ; Wichmann, H. E. ; Heinrich, J. ; Papageorgiou, N. ; Avarlis, P. ; Gaga, M. ; Marossis, C. ; Gislason, T. ; Gislason, D. ; Bugiani, M. ; Bucca, C. ; Romano, C. ; Marinoni, A. ; Cerveri, T. ; Casali, L. ; Kremer, A. ; Crane, J. ; Lewis, S. ; Gulsvik, A. ; Omenaas, E. ; Muniozguren, N. ; Ramos González, J. ; Capelastegui, A. ; Castillo, J. ; Rodriguez Portal, J. ; Martinez-Moratalla, J. ; Almar, E. ; Maldonado Pérez, J. ; Pereira, A. ; Sánchez, J. ; Quiros, J. ; Huerta, I. ; Pavo, F. ; Rosenhall, L. ; Norrman, E. ; Lundbäck, B. ; Lindholm, N. ; Plaschke, P. ; Ackermann-Liebrich, U. ; Künzli, N. ; Perruchoud, A. ; Burr, M. ; Layzell, J. ; Hall, R. ; Harrison, B. ; Stark, J. ; Buist, A (Sonia) ; Vollmer, W. ; Osborne, Molly. / Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS). In: European Respiratory Journal. 1997 ; Vol. 10, No. 11. pp. 2495-2501.
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abstract = "Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge delivered by Mefar dosimeter according to a standardized protocol used in 35 centres in 16 countries. Data were obtained from 13,161 men and women, aged 20-44 yrs at the start of the study. The dose of methacholine producing a 20{\%} fall in forced expiratory volume in one second (FEV1) (PD20) and the regression coefficient of percentage decline in FEV1 with log dose, were calculated ('slope', after transformation), with and without calibration of nebulizers by weight and adjustment for nonresponsc bias. Standardization for baseline lung function and variation in smoking prevalence was applied to slope. Results were robust to whichever summary measure was used, and to the various adjustments. Responsiveness was low in Iceland and Switzerland, and in most centres in Sweden, Italy and Spain, and high in New Zealand, Australia, the USA, Britain, France, Denmark and Germany. Bronchial responsiveness varies considerably in Europe, and high levels are not confined to the English-speaking world.",
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TY - JOUR

T1 - Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)

AU - Chinn, S.

AU - Burney, P.

AU - Jarvis, D.

AU - Luczynska, C.

AU - Lai, E.

AU - Burney, P.

AU - Chinn, S.

AU - Luczynska, C.

AU - Jarvis, D.

AU - Vermeire, P.

AU - Kesteloot, H.

AU - Bousquet, J.

AU - Bousquet, J.

AU - Knani, J.

AU - Nowak, D.

AU - Magnussen, H.

AU - Prichard, J.

AU - Allwright, S.

AU - MacLeod, D.

AU - de Marco, R.

AU - Lo Cascio, R. de Marco

AU - Campello, C.

AU - Rijcken, B.

AU - Antó, J. M.

AU - Sunyer, J.

AU - Burgos, F.

AU - Castellsagué, J.

AU - Roca, J.

AU - Soriano, J. B.

AU - Tobías, A.

AU - Alves, J.

AU - Marques, J. A.

AU - Boman, G.

AU - Janson, C.

AU - Björnsson, E.

AU - Nielsen, N.

AU - Paoletti, P.

AU - Popp, W.

AU - Abramson, M.

AU - Kutin, J.

AU - Vermeire, P.

AU - van Bastelaer, F.

AU - Neukirch, F.

AU - Liard, R.

AU - Pin, I.

AU - Pison, C.

AU - Taytard, A.

AU - Wichmann, H. E.

AU - Heinrich, J.

AU - Papageorgiou, N.

AU - Avarlis, P.

AU - Gaga, M.

AU - Marossis, C.

AU - Gislason, T.

AU - Gislason, D.

AU - Bugiani, M.

AU - Bucca, C.

AU - Romano, C.

AU - Marinoni, A.

AU - Cerveri, T.

AU - Casali, L.

AU - Kremer, A.

AU - Crane, J.

AU - Lewis, S.

AU - Gulsvik, A.

AU - Omenaas, E.

AU - Muniozguren, N.

AU - Ramos González, J.

AU - Capelastegui, A.

AU - Castillo, J.

AU - Rodriguez Portal, J.

AU - Martinez-Moratalla, J.

AU - Almar, E.

AU - Maldonado Pérez, J.

AU - Pereira, A.

AU - Sánchez, J.

AU - Quiros, J.

AU - Huerta, I.

AU - Pavo, F.

AU - Rosenhall, L.

AU - Norrman, E.

AU - Lundbäck, B.

AU - Lindholm, N.

AU - Plaschke, P.

AU - Ackermann-Liebrich, U.

AU - Künzli, N.

AU - Perruchoud, A.

AU - Burr, M.

AU - Layzell, J.

AU - Hall, R.

AU - Harrison, B.

AU - Stark, J.

AU - Buist, A (Sonia)

AU - Vollmer, W.

AU - Osborne, Molly

PY - 1997/11

Y1 - 1997/11

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KW - Bronchial provocation tests

KW - Epidemiology

KW - Methacholine

KW - Multi-centre study

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