Variable degree of Growth Hormone (GH) and Insulin-like Growth Factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients

Evidence from an IGF-based dosing study of short children

Pinchas Cohen, John Germak, Alan D. Rogol, Wayne Weng, Anne Marie Kappelgaard, Ronald (Ron) Rosenfeld

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Context: We recently showed that, in IGF-based GH therapy, the IGF-I target chosen affects GH dose requirements, and higher IGF-I targets are associated with more robust growth parameters. Objective: The objective of the study was to compare the response of GH-deficient (GHD) vs. idiopathic short-stature (ISS) children to IGF-based GH therapy. Design: This was a 2-yr, open-label, randomized trial. Setting: The setting was multicenter and outpatient. Patients: Prepubertal short children [height SD score (SDS)

Original languageEnglish (US)
Pages (from-to)2089-2098
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume95
Issue number5
DOIs
StatePublished - May 2010

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ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Variable degree of Growth Hormone (GH) and Insulin-like Growth Factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients : Evidence from an IGF-based dosing study of short children. / Cohen, Pinchas; Germak, John; Rogol, Alan D.; Weng, Wayne; Kappelgaard, Anne Marie; Rosenfeld, Ronald (Ron).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 5, 05.2010, p. 2089-2098.

Research output: Contribution to journalArticle

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