Value of intraoperative parathyroid hormone monitoring

Jyotirmay Sharma, Kresimira Milas, Eren Berber, Peter Mazzaglia, Alan Siperstein, Collin J. Weber

Research output: Contribution to journalArticle

23 Scopus citations


Background: Routine use of intraoperative parathyroid hormone (IOPTH) has been challenged in both unilateral/limited (LE) and bilateral exploration (BE). To investigate this, we assessed the usefulness of IOPTH in surgical management of primary hyperparathyroidism and parathyroid carcinoma (PC). Methods: Between 1998 and 2006, 1133 patients were explored for hyperparathyroidism: 185 LE, 743 BE with IOPTH, 95 BE without IOPTH, 110 reoperations, and 4 PCs. IOPTH patterns were correlated with parathyroid pathology (single adenoma [SA] or multigland disease [MGD]) and operative success. Results: In LE, IOPTH returned to normal in 78% of patients; all patients had SA, and 99% were cured at a mean ± SEM of 1.2 ± .24 years; 22% of LE patients (n = 41) whose IOPTH did not return to normal were converted to BE, and all had MGD. BE with and without IOPTH was equally successful 97% and 98% (P = NS) of the time, respectively. In BE in which IOPTH did not return to normal, 9% of patients remained hypercalcemic; tumor distribution mirrored other BE patients (75% SA, 25% MGD). In reoperations, a normal final IOPTH correlated with cure in 99%; otherwise, 59% had persistent disease. Differential bilateral internal jugular vein IOPTH sampling lateralized disease in 77% of reoperations. Conclusions: IOPTH is an important adjunct for successful LE by identifying the presence of MGD and avoiding operative failure. IOPTH adds little to BE; however, final IOPTH values may predict persistent disease in BE, reoperations, and PCs.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalAnnals of Surgical Oncology
Issue number2
StatePublished - Feb 2008
Externally publishedYes



  • Hyperparathyroidism
  • Intraoperative Parathyroid Hormone
  • Minimally invasive parathyrodectomy
  • Parathyroid Hormone Kinetics
  • Parathyroidectomy
  • Reoperative Parathyroidectomy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Sharma, J., Milas, K., Berber, E., Mazzaglia, P., Siperstein, A., & Weber, C. J. (2008). Value of intraoperative parathyroid hormone monitoring. Annals of Surgical Oncology, 15(2), 493-498.