Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

Barbara Visentin, John A. Vekich, Bradley J. Sibbald, Amy L. Cavalli, Kelli M. Moreno, Rosalia G. Matteo, William A. Garland, Yiling Lu, Shuangxing Yu, Hassan S. Hall, Vikas Kundra, Gordon Mills, Roger A. Sabbadini

Research output: Contribution to journalArticle

366 Citations (Scopus)

Abstract

S1P has been proposed to contribute to cancer progression by regulating tumor proliferation, invasion, and angiogenesis. We developed a biospecific monoclonal antibody to S1P to investigate its role in tumorigenesis. The anti-S1P mAb substantially reduced tumor progression and in some cases eliminated measurable tumors in murine xenograft and allograft models. Tumor growth inhibition was attributed to antiangiogenic and antitumorigenic effects of the antibody. The anti-S1P mAb blocked EC migration and resulting capillary formation, inhibited blood vessel formation induced by VEGF and bFGF, and arrested tumor-associated angiogenesis. The anti-S1P mAb also neutralized S1P-induced proliferation, release of proangiogenic cytokines, and the ability of S1P to protect tumor cells from apoptosis in several tumor cell lines, validating S1P as a target for therapy.

Original languageEnglish (US)
Pages (from-to)225-238
Number of pages14
JournalCancer Cell
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

Antibodies
Growth
Neoplasms
Therapeutics
sphingosine 1-phosphate
Tumor Cell Line
Heterografts
Vascular Endothelial Growth Factor A
Allografts
Blood Vessels
Carcinogenesis
Monoclonal Antibodies
Apoptosis
Cytokines

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Visentin, B., Vekich, J. A., Sibbald, B. J., Cavalli, A. L., Moreno, K. M., Matteo, R. G., ... Sabbadini, R. A. (2006). Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell, 9(3), 225-238. https://doi.org/10.1016/j.ccr.2006.02.023

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. / Visentin, Barbara; Vekich, John A.; Sibbald, Bradley J.; Cavalli, Amy L.; Moreno, Kelli M.; Matteo, Rosalia G.; Garland, William A.; Lu, Yiling; Yu, Shuangxing; Hall, Hassan S.; Kundra, Vikas; Mills, Gordon; Sabbadini, Roger A.

In: Cancer Cell, Vol. 9, No. 3, 01.03.2006, p. 225-238.

Research output: Contribution to journalArticle

Visentin, B, Vekich, JA, Sibbald, BJ, Cavalli, AL, Moreno, KM, Matteo, RG, Garland, WA, Lu, Y, Yu, S, Hall, HS, Kundra, V, Mills, G & Sabbadini, RA 2006, 'Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages', Cancer Cell, vol. 9, no. 3, pp. 225-238. https://doi.org/10.1016/j.ccr.2006.02.023
Visentin, Barbara ; Vekich, John A. ; Sibbald, Bradley J. ; Cavalli, Amy L. ; Moreno, Kelli M. ; Matteo, Rosalia G. ; Garland, William A. ; Lu, Yiling ; Yu, Shuangxing ; Hall, Hassan S. ; Kundra, Vikas ; Mills, Gordon ; Sabbadini, Roger A. / Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. In: Cancer Cell. 2006 ; Vol. 9, No. 3. pp. 225-238.
@article{549f276d63f14c479dd3b63a018c2938,
title = "Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages",
abstract = "S1P has been proposed to contribute to cancer progression by regulating tumor proliferation, invasion, and angiogenesis. We developed a biospecific monoclonal antibody to S1P to investigate its role in tumorigenesis. The anti-S1P mAb substantially reduced tumor progression and in some cases eliminated measurable tumors in murine xenograft and allograft models. Tumor growth inhibition was attributed to antiangiogenic and antitumorigenic effects of the antibody. The anti-S1P mAb blocked EC migration and resulting capillary formation, inhibited blood vessel formation induced by VEGF and bFGF, and arrested tumor-associated angiogenesis. The anti-S1P mAb also neutralized S1P-induced proliferation, release of proangiogenic cytokines, and the ability of S1P to protect tumor cells from apoptosis in several tumor cell lines, validating S1P as a target for therapy.",
author = "Barbara Visentin and Vekich, {John A.} and Sibbald, {Bradley J.} and Cavalli, {Amy L.} and Moreno, {Kelli M.} and Matteo, {Rosalia G.} and Garland, {William A.} and Yiling Lu and Shuangxing Yu and Hall, {Hassan S.} and Vikas Kundra and Gordon Mills and Sabbadini, {Roger A.}",
year = "2006",
month = "3",
day = "1",
doi = "10.1016/j.ccr.2006.02.023",
language = "English (US)",
volume = "9",
pages = "225--238",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

AU - Visentin, Barbara

AU - Vekich, John A.

AU - Sibbald, Bradley J.

AU - Cavalli, Amy L.

AU - Moreno, Kelli M.

AU - Matteo, Rosalia G.

AU - Garland, William A.

AU - Lu, Yiling

AU - Yu, Shuangxing

AU - Hall, Hassan S.

AU - Kundra, Vikas

AU - Mills, Gordon

AU - Sabbadini, Roger A.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - S1P has been proposed to contribute to cancer progression by regulating tumor proliferation, invasion, and angiogenesis. We developed a biospecific monoclonal antibody to S1P to investigate its role in tumorigenesis. The anti-S1P mAb substantially reduced tumor progression and in some cases eliminated measurable tumors in murine xenograft and allograft models. Tumor growth inhibition was attributed to antiangiogenic and antitumorigenic effects of the antibody. The anti-S1P mAb blocked EC migration and resulting capillary formation, inhibited blood vessel formation induced by VEGF and bFGF, and arrested tumor-associated angiogenesis. The anti-S1P mAb also neutralized S1P-induced proliferation, release of proangiogenic cytokines, and the ability of S1P to protect tumor cells from apoptosis in several tumor cell lines, validating S1P as a target for therapy.

AB - S1P has been proposed to contribute to cancer progression by regulating tumor proliferation, invasion, and angiogenesis. We developed a biospecific monoclonal antibody to S1P to investigate its role in tumorigenesis. The anti-S1P mAb substantially reduced tumor progression and in some cases eliminated measurable tumors in murine xenograft and allograft models. Tumor growth inhibition was attributed to antiangiogenic and antitumorigenic effects of the antibody. The anti-S1P mAb blocked EC migration and resulting capillary formation, inhibited blood vessel formation induced by VEGF and bFGF, and arrested tumor-associated angiogenesis. The anti-S1P mAb also neutralized S1P-induced proliferation, release of proangiogenic cytokines, and the ability of S1P to protect tumor cells from apoptosis in several tumor cell lines, validating S1P as a target for therapy.

UR - http://www.scopus.com/inward/record.url?scp=33644830810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644830810&partnerID=8YFLogxK

U2 - 10.1016/j.ccr.2006.02.023

DO - 10.1016/j.ccr.2006.02.023

M3 - Article

C2 - 16530706

AN - SCOPUS:33644830810

VL - 9

SP - 225

EP - 238

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 3

ER -