Validation of a digital color Doppler flow measurement method for pulmonary regurgitant volumes and regurgitant fractions in an in vitro model and in a chronic animal model of postoperative repaired tetralogy of Fallot

Yoshiki Mori, Timothy Irvine, Michael Jones, Rosemary A. Rusk, Quynh Pham, Antoinette Kenny, David Sahn

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Abstract

OBJECTIVES: The purpose of this study was to validate a digital color Doppler (DCD) automated cardiac flow measurement method for quantifying pulmonary regurgitation (PR) in an in vitro and a chronic animal model of the right ventricular outflow tract of postoperative tetralogy of Fallot (TOF). BACKGROUND: There has been no reliable ultrasound method that can accurately quantitate PR. METHODS: We developed an in vitro model of mild pulmonary stenosis and wide-open PR that mimics the patterns of flow seen in patients with postoperative TOF. Thirteen different forward and regurgitant stroke volumes (RSVs) across the noncircular shaped cross-sectional outflow tract flow area were estimated using the DCD method in two orthogonal planes. In six sheep with surgically created PR, 24 different hemodynamic states with PR strictly quantified by electromagnetic probes were also studied. RESULTS: The RSVs and regurgitant fractions (RFs) obtained by the DCD method using average values from two orthogonal planes correlated well with reference values (RSV: r = 0.99, mean difference = 0.02 ± 0.39 ml/beat for in vitro model; r = 0.97, mean differences = 1.79 ± 1.84 ml/beat for animal model, RF: r = 0.98, mean difference = -1.10 ± 4.34% for in vitro model; r = 0.94, mean difference = 2.73 ± 6.75% for animal model). However, the DCD method using a single plane had limited accuracy for estimating pulmonary RFs and RSVs. CONCLUSIONS: The DCD method using average values from two orthogonal planes provides accurate estimation of RSVs and RFs and should have clinical importance for serially quantifying PR in patients with postoperative TOF.

Original languageEnglish (US)
Pages (from-to)632-640
Number of pages9
JournalJournal of the American College of Cardiology
Volume37
Issue number2
DOIs
StatePublished - 2001

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Pulmonary Valve Insufficiency
Tetralogy of Fallot
Stroke Volume
Animal Models
Color
Lung
Animal Rights
Pulmonary Valve Stenosis
Electromagnetic Phenomena
In Vitro Techniques
Sheep
Reference Values
Hemodynamics

ASJC Scopus subject areas

  • Nursing(all)

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Validation of a digital color Doppler flow measurement method for pulmonary regurgitant volumes and regurgitant fractions in an in vitro model and in a chronic animal model of postoperative repaired tetralogy of Fallot. / Mori, Yoshiki; Irvine, Timothy; Jones, Michael; Rusk, Rosemary A.; Pham, Quynh; Kenny, Antoinette; Sahn, David.

In: Journal of the American College of Cardiology, Vol. 37, No. 2, 2001, p. 632-640.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVES: The purpose of this study was to validate a digital color Doppler (DCD) automated cardiac flow measurement method for quantifying pulmonary regurgitation (PR) in an in vitro and a chronic animal model of the right ventricular outflow tract of postoperative tetralogy of Fallot (TOF). BACKGROUND: There has been no reliable ultrasound method that can accurately quantitate PR. METHODS: We developed an in vitro model of mild pulmonary stenosis and wide-open PR that mimics the patterns of flow seen in patients with postoperative TOF. Thirteen different forward and regurgitant stroke volumes (RSVs) across the noncircular shaped cross-sectional outflow tract flow area were estimated using the DCD method in two orthogonal planes. In six sheep with surgically created PR, 24 different hemodynamic states with PR strictly quantified by electromagnetic probes were also studied. RESULTS: The RSVs and regurgitant fractions (RFs) obtained by the DCD method using average values from two orthogonal planes correlated well with reference values (RSV: r = 0.99, mean difference = 0.02 ± 0.39 ml/beat for in vitro model; r = 0.97, mean differences = 1.79 ± 1.84 ml/beat for animal model, RF: r = 0.98, mean difference = -1.10 ± 4.34{\%} for in vitro model; r = 0.94, mean difference = 2.73 ± 6.75{\%} for animal model). However, the DCD method using a single plane had limited accuracy for estimating pulmonary RFs and RSVs. CONCLUSIONS: The DCD method using average values from two orthogonal planes provides accurate estimation of RSVs and RFs and should have clinical importance for serially quantifying PR in patients with postoperative TOF.",
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AU - Kenny, Antoinette

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