Uteroplacental circulation and fetal vascular function and development

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Although blood flow in the placental vasculature is governed by the same physiological forces of shear, pressure and resistance as in other organs, it is also uniquely specialized on the maternal and fetal sides. At the materno-fetal interface, the independent uteroplacental and umbilicoplacental circulations must coordinate sufficiently to supply the fetus with the nutrients and substrates it needs to grow and develop. Uterine arterial flow must increase dramatically to accommodate the growing fetus. Recent evidence delineates the hormonal and endothelial mechanisms by which maternal vessels dilate and remodel during pregnancy. The umbilical circulation is established de novo during embryonic development but blood does not flow through the placenta until late in the first trimester. The umbilical circulation operates in the interest of maintaining fetal oxygenation over the course of pregnancy, and is affected differently by mechanical and chemical regulators of vascular tone compared to other organs. The processes that match placental vascular growth and fetal tissue growth are not understood, but studies of compromised pregnancies provide clues. The subtle changes that cause the failure of the normally regulated vascular processes during pregnancy have not been thoroughly identified. Likewise, practical and effective therapeutic strategies to reverse detrimental placental perfusion patterns have yet to be investigated.

    Original languageEnglish (US)
    Pages (from-to)748-757
    Number of pages10
    JournalCurrent Vascular Pharmacology
    Volume11
    Issue number5
    StatePublished - 2013

    Fingerprint

    Placental Circulation
    Blood Vessels
    Umbilicus
    Pregnancy
    Fetus
    Mothers
    First Pregnancy Trimester
    Fetal Development
    Placenta
    Embryonic Development
    Perfusion
    Pressure
    Food
    Growth

    Keywords

    • Blood flow regulation
    • Compromise
    • Placental insufficiency
    • Pregnancy
    • Vasculature

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Pharmacology

    Cite this

    Uteroplacental circulation and fetal vascular function and development. / Thornburg, Kent; Louey, Samantha.

    In: Current Vascular Pharmacology, Vol. 11, No. 5, 2013, p. 748-757.

    Research output: Contribution to journalArticle

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