Use of a new elastin patch and glue for repair of a major duodenal injury

Michio Kajitani, Yasmin Wadia, Hua Xie, Monica Hinds, Shalaby W. Shalaby, Kim R. Swartz, Kenton Gregory

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Major duodenal injury with significant tissue loss causes high morbidity and mortality. Our new elastin based heterograft combined with small intestinal submucosa (SIS) and biodegradable glue could be used for repair of such defects. Twenty-four domestic pigs were anesthetized and underwent celiotomy. A 2 cm circular defect was created at the second portion of the duodenum with scissors, excising one-half of its circumference. Our elastin patch, combined with SIS, was applied to cover the defect using biodegradable cyanoacrylate glue and a few sutures. It was then covered with omentum. Animals were followed by weight gain, endoscopic evaluation, and upper Gl barium studies. After 2-5 months, animals were sacrificed to obtain specimens. One failed in 3 days due to a technical problem, and one failed in 20 days due to an abdominal abscess. The other 22 animals (22/24, 91.7%) did well, gaining weight. Early endoscopic studies (5-14 d) showed an intact patch. Upper Gl studies showed varying degrees of stenosis at the repair site at 3-4 months. Sacrifice after 2-5 months showed complete healing of the defect and a dissolved patch. Our new elastin patch material provides a reliable barrier for repair of duodenal injury, and the biodegradable glue provides quick and easy watertight tissue fusion for our patch.

Original languageEnglish (US)
Pages (from-to)409-414
Number of pages6
JournalASAIO Journal
Volume46
Issue number4
StatePublished - Jul 2000

Fingerprint

Elastin
Glues
Adhesives
Repair
Defects
Animals
Wounds and Injuries
Cyanoacrylates
Abdominal Abscess
Sus scrofa
Omentum
Barium
Tissue
Duodenum
Heterografts
Sutures
Weight Gain
Pathologic Constriction
Morbidity
Weights and Measures

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Kajitani, M., Wadia, Y., Xie, H., Hinds, M., Shalaby, S. W., Swartz, K. R., & Gregory, K. (2000). Use of a new elastin patch and glue for repair of a major duodenal injury. ASAIO Journal, 46(4), 409-414.

Use of a new elastin patch and glue for repair of a major duodenal injury. / Kajitani, Michio; Wadia, Yasmin; Xie, Hua; Hinds, Monica; Shalaby, Shalaby W.; Swartz, Kim R.; Gregory, Kenton.

In: ASAIO Journal, Vol. 46, No. 4, 07.2000, p. 409-414.

Research output: Contribution to journalArticle

Kajitani, M, Wadia, Y, Xie, H, Hinds, M, Shalaby, SW, Swartz, KR & Gregory, K 2000, 'Use of a new elastin patch and glue for repair of a major duodenal injury', ASAIO Journal, vol. 46, no. 4, pp. 409-414.
Kajitani M, Wadia Y, Xie H, Hinds M, Shalaby SW, Swartz KR et al. Use of a new elastin patch and glue for repair of a major duodenal injury. ASAIO Journal. 2000 Jul;46(4):409-414.
Kajitani, Michio ; Wadia, Yasmin ; Xie, Hua ; Hinds, Monica ; Shalaby, Shalaby W. ; Swartz, Kim R. ; Gregory, Kenton. / Use of a new elastin patch and glue for repair of a major duodenal injury. In: ASAIO Journal. 2000 ; Vol. 46, No. 4. pp. 409-414.
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