Use of a chitosan-based hemostatic dressing in laparoscopic partial nephrectomy

Hua Xie, Yashodhan S. Khajanchee, Jeffrey S. Teach, Brian S. Shaffer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objectives: An external chitosan-based hemostatic bandage has been used to control aggressive bleeding from traumatic injuries. This study was to evaluate the feasibility of using an internal chitosan dressing based on the external platform to control hemorrhage and urinary leakage by sealing off the parenchymal wound following Laparoscopic partial nephrectomy (LPN) in a porcine model. Methods: Nine heparinized domestic swine underwent bilateral laparoscopic partial nephrectomies involving either a polar (N = 13) or wedge resection (N = 5) followed by treatment with the chitosan dressing. Estimated blood loss, hemostatic score, urinary leakage, operative time, and adhesion score of the chitosan dressing were recorded. Results: Of the 18 procedures, 17 achieved complete hemostasis after deployment of the chitosan dressing. The hemostasis score improved significantly after the deployment in both polar (p < 0.001) and wedge (p = 0.017) resections. The rate of successful pyelocaliceal sealing was 85% (11/13) in polar resections and 60% (3/5) in wedge resections. Conclusion: The chitosan-based hemostatic dressing is effective as a primary or supplemental material for controlling parenchymal hemorrhage and sealing the renal collecting system following LPN in the animal model.

Original languageEnglish (US)
Pages (from-to)267-271
Number of pages5
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number1
StatePublished - Apr 2008


  • Chitosan
  • Hemostasis
  • Laparoscopic
  • Nephrectomy

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Use of a chitosan-based hemostatic dressing in laparoscopic partial nephrectomy'. Together they form a unique fingerprint.

Cite this