Uptake of fatty acids by the developing rat brain

Gregory Anderson, William E. Connor

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Polyunsaturated fatty acids are avidly taken up by the developing rat brain. To explore the specificity of this process, [1-14C]labeled 16:0, 18:2n-6, 18:3n-3, and 22:6n-3 each were co-injected with [3H]18:1n-9 into the jugular vein of two-wk-old functionally hepatectomized and shamoperated control rats. The radioactivities present in the brain, liver and serum were assessed 30 min after injection. Uptake of labeled fatty acids into brain lipids steadily increased with increasing degree of unsaturation, with more than twice as much uptake of 22:6n-3 compared to 16:0. Phosphatidylcholine was the principal radioactive species in the brain except for animals injected with [1-14C]22:6n-3, in which more of the label was incorporated into phosphatidylethanolamine. Determination of watersoluble oxidation products in the brain and serum revealed that the greater uptake of the more unsatrated fatty acids did not result from differences in rates of degradation.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalLipids
Volume23
Issue number4
DOIs
StatePublished - Apr 1988

Fingerprint

Rats
Brain
Fatty Acids
fatty acids
uptake mechanisms
brain
rats
Rat control
Jugular Veins
jugular vein
Radioactivity
phosphatidylethanolamines
Serum
Phosphatidylcholines
Unsaturated Fatty Acids
phosphatidylcholines
Liver
polyunsaturated fatty acids
Labels
Animals

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Organic Chemistry
  • Cell Biology

Cite this

Uptake of fatty acids by the developing rat brain. / Anderson, Gregory; Connor, William E.

In: Lipids, Vol. 23, No. 4, 04.1988, p. 286-290.

Research output: Contribution to journalArticle

Anderson, G & Connor, WE 1988, 'Uptake of fatty acids by the developing rat brain', Lipids, vol. 23, no. 4, pp. 286-290. https://doi.org/10.1007/BF02537334
Anderson, Gregory ; Connor, William E. / Uptake of fatty acids by the developing rat brain. In: Lipids. 1988 ; Vol. 23, No. 4. pp. 286-290.
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