Unlocking the molecular secrets of sodium-coupled transporters

Harini Krishnamurthy, Chayne L. Piscitelli, Eric Gouaux

Research output: Contribution to journalArticle

241 Citations (Scopus)

Abstract

Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes.

Original languageEnglish (US)
Pages (from-to)347-355
Number of pages9
JournalNature
Volume459
Issue number7245
DOIs
StatePublished - May 21 2009

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Sodium
Physiological Phenomena
Ions
Membranes

ASJC Scopus subject areas

  • General

Cite this

Unlocking the molecular secrets of sodium-coupled transporters. / Krishnamurthy, Harini; Piscitelli, Chayne L.; Gouaux, Eric.

In: Nature, Vol. 459, No. 7245, 21.05.2009, p. 347-355.

Research output: Contribution to journalArticle

Krishnamurthy, H, Piscitelli, CL & Gouaux, E 2009, 'Unlocking the molecular secrets of sodium-coupled transporters', Nature, vol. 459, no. 7245, pp. 347-355. https://doi.org/10.1038/nature08143
Krishnamurthy, Harini ; Piscitelli, Chayne L. ; Gouaux, Eric. / Unlocking the molecular secrets of sodium-coupled transporters. In: Nature. 2009 ; Vol. 459, No. 7245. pp. 347-355.
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