Unlocking the molecular secrets of sodium-coupled transporters

Harini Krishnamurthy, Chayne L. Piscitelli, Eric Gouaux

Research output: Contribution to journalReview article

247 Scopus citations

Abstract

Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes.

Original languageEnglish (US)
Pages (from-to)347-355
Number of pages9
JournalNature
Volume459
Issue number7245
DOIs
StatePublished - May 21 2009

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