Uniparental disomy in cancer

Musaffe Tuna, Sakari Knuutila, Gordon Mills

Research output: Contribution to journalReview article

128 Citations (Scopus)

Abstract

Uniparental disomy (UPD) results when both copies of a chromosome pair originate from one parent. In humans, this might result in developmental disease or cancer due to either the production of homozygosity (caused by mutated or methylated genes or by microRNA sequences) or an aberrant pattern of imprinting. Constitutional UPD is associated with meiotic errors, resulting in developmental diseases, whereas acquired UPD probably occurs as a result of a mitotic error in somatic cells, which can be an important step in cancer development and progression. This review summarizes the mechanisms underlying UPD and their emerging association with cancer.

Original languageEnglish (US)
Pages (from-to)120-128
Number of pages9
JournalTrends in Molecular Medicine
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2009
Externally publishedYes

Fingerprint

Uniparental Disomy
Neoplasms
MicroRNAs
Chromosomes
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Uniparental disomy in cancer. / Tuna, Musaffe; Knuutila, Sakari; Mills, Gordon.

In: Trends in Molecular Medicine, Vol. 15, No. 3, 01.03.2009, p. 120-128.

Research output: Contribution to journalReview article

Tuna, Musaffe ; Knuutila, Sakari ; Mills, Gordon. / Uniparental disomy in cancer. In: Trends in Molecular Medicine. 2009 ; Vol. 15, No. 3. pp. 120-128.
@article{373eeeae67494f1f8f6c842c48b1dea4,
title = "Uniparental disomy in cancer",
abstract = "Uniparental disomy (UPD) results when both copies of a chromosome pair originate from one parent. In humans, this might result in developmental disease or cancer due to either the production of homozygosity (caused by mutated or methylated genes or by microRNA sequences) or an aberrant pattern of imprinting. Constitutional UPD is associated with meiotic errors, resulting in developmental diseases, whereas acquired UPD probably occurs as a result of a mitotic error in somatic cells, which can be an important step in cancer development and progression. This review summarizes the mechanisms underlying UPD and their emerging association with cancer.",
author = "Musaffe Tuna and Sakari Knuutila and Gordon Mills",
year = "2009",
month = "3",
day = "1",
doi = "10.1016/j.molmed.2009.01.005",
language = "English (US)",
volume = "15",
pages = "120--128",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Uniparental disomy in cancer

AU - Tuna, Musaffe

AU - Knuutila, Sakari

AU - Mills, Gordon

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Uniparental disomy (UPD) results when both copies of a chromosome pair originate from one parent. In humans, this might result in developmental disease or cancer due to either the production of homozygosity (caused by mutated or methylated genes or by microRNA sequences) or an aberrant pattern of imprinting. Constitutional UPD is associated with meiotic errors, resulting in developmental diseases, whereas acquired UPD probably occurs as a result of a mitotic error in somatic cells, which can be an important step in cancer development and progression. This review summarizes the mechanisms underlying UPD and their emerging association with cancer.

AB - Uniparental disomy (UPD) results when both copies of a chromosome pair originate from one parent. In humans, this might result in developmental disease or cancer due to either the production of homozygosity (caused by mutated or methylated genes or by microRNA sequences) or an aberrant pattern of imprinting. Constitutional UPD is associated with meiotic errors, resulting in developmental diseases, whereas acquired UPD probably occurs as a result of a mitotic error in somatic cells, which can be an important step in cancer development and progression. This review summarizes the mechanisms underlying UPD and their emerging association with cancer.

UR - http://www.scopus.com/inward/record.url?scp=62249091705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62249091705&partnerID=8YFLogxK

U2 - 10.1016/j.molmed.2009.01.005

DO - 10.1016/j.molmed.2009.01.005

M3 - Review article

C2 - 19246245

AN - SCOPUS:62249091705

VL - 15

SP - 120

EP - 128

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 3

ER -