Unequal placental sharing and birth weight discordance in monochorionic diamniotic twins

Andrea L. Fick, Vickie A. Feldstein, Mary E. Norton, Christina Wassel Fyr, Aaron Caughey, Geoffrey A. Machin

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Objective: The purpose of this study was to define the association between unequal placental sharing and birth weight discordance in monochorionic/diamniotic twin pregnancies. Study design: The study comprised a prospective cohort of monochorionic/diamniotic twin pregnancies who were delivered in Kaiser Permanente-Northern California, 1997-2003. Dye injection studies of fresh postpartum placentas were performed. Placental sharing, cord insertion combinations, vascular anastomoses, gestational age, and birth weights were recorded. Statistical comparisons of birth weight and gestational age were made with the Student t test. Rates of birth weight discordance were compared with the chi-square test. Multivariate logistic regression models analyzed the relationship between variables of interest. Results: Mean birth weights for larger and smaller twins were 2400 g and 2109 g, respectively. Twenty-two percent of the monochorionic/diamniotic twin pairs had birth weight discordance ≥20%, and 8% of these pairs had twin-twin transfusion syndrome. Monochorionic/diamniotic twin pairs with unequal placental sharing had a 9.8 times greater likelihood of birth weight discordance (95% CI, 5.4-17.9) as compared with those pairs with equal placental sharing. Conclusion: Unequal placental sharing is a significant risk factor for birth weight discordance in monochorionic/diamniotic twins. Antenatal diagnosis of unequal placental sharing would enable improved counseling in the setting of monochorionic/diamniotic twins.

Original languageEnglish (US)
Pages (from-to)178-183
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume195
Issue number1
DOIs
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Birth Weight
Twin Pregnancy
Gestational Age
Logistic Models
Fetofetal Transfusion
Chi-Square Distribution
Prenatal Diagnosis
Postpartum Period
Placenta
Blood Vessels
Counseling
Coloring Agents
Students
Injections

Keywords

  • Growth discordance
  • Monochorionic twins
  • Placental sharing
  • Twin-twin transfusion syndrome

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Unequal placental sharing and birth weight discordance in monochorionic diamniotic twins. / Fick, Andrea L.; Feldstein, Vickie A.; Norton, Mary E.; Wassel Fyr, Christina; Caughey, Aaron; Machin, Geoffrey A.

In: American Journal of Obstetrics and Gynecology, Vol. 195, No. 1, 07.2006, p. 178-183.

Research output: Contribution to journalArticle

Fick, Andrea L. ; Feldstein, Vickie A. ; Norton, Mary E. ; Wassel Fyr, Christina ; Caughey, Aaron ; Machin, Geoffrey A. / Unequal placental sharing and birth weight discordance in monochorionic diamniotic twins. In: American Journal of Obstetrics and Gynecology. 2006 ; Vol. 195, No. 1. pp. 178-183.
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