TY - JOUR
T1 - Understanding the microbiome
T2 - A primer on the role of the microbiome in colorectal neoplasia
AU - Watson, Katherine M.
AU - Gaulke, Christopher A.
AU - Tsikitis, Vassiliki Liana
N1 - Publisher Copyright:
© 2020 Hellenic Society of Gastroenterology.
PY - 2020/5/9
Y1 - 2020/5/9
N2 - Colorectal cancer is a leading cause of cancer-related death internationally, with mounting evidence pointing to the role of the microbiome in adenoma and cancer development. This article aims to provide clinicians with a foundation for understanding the field of research into the microbiome. We also illustrate the various ways in which the microbiota have been linked to colorectal cancer, with a specific focus on microbiota with identified virulence factors, and also on the ways that byproducts of microbiota metabolism may result in oncogenesis. We also review strategies for manipulating the microbiome for therapeutic effects.
AB - Colorectal cancer is a leading cause of cancer-related death internationally, with mounting evidence pointing to the role of the microbiome in adenoma and cancer development. This article aims to provide clinicians with a foundation for understanding the field of research into the microbiome. We also illustrate the various ways in which the microbiota have been linked to colorectal cancer, with a specific focus on microbiota with identified virulence factors, and also on the ways that byproducts of microbiota metabolism may result in oncogenesis. We also review strategies for manipulating the microbiome for therapeutic effects.
KW - Colorectal adenomas
KW - Colorectal cancer
KW - Microbiome
UR - http://www.scopus.com/inward/record.url?scp=85084820840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084820840&partnerID=8YFLogxK
U2 - 10.20524/aog.2020.0467
DO - 10.20524/aog.2020.0467
M3 - Review article
AN - SCOPUS:85084820840
SN - 1108-7471
VL - 33
SP - 223
EP - 236
JO - Annals of Gastroenterology
JF - Annals of Gastroenterology
IS - 3
ER -