Understanding the microbiome: A primer on the role of the microbiome in colorectal neoplasia

Katherine M. Watson, Christopher A. Gaulke, Vassiliki Liana Tsikitis

    Research output: Contribution to journalReview articlepeer-review

    4 Scopus citations

    Abstract

    Colorectal cancer is a leading cause of cancer-related death internationally, with mounting evidence pointing to the role of the microbiome in adenoma and cancer development. This article aims to provide clinicians with a foundation for understanding the field of research into the microbiome. We also illustrate the various ways in which the microbiota have been linked to colorectal cancer, with a specific focus on microbiota with identified virulence factors, and also on the ways that byproducts of microbiota metabolism may result in oncogenesis. We also review strategies for manipulating the microbiome for therapeutic effects.

    Original languageEnglish (US)
    Pages (from-to)223-236
    Number of pages14
    JournalAnnals of Gastroenterology
    Volume33
    Issue number3
    DOIs
    StatePublished - May 9 2020

    Keywords

    • Colorectal adenomas
    • Colorectal cancer
    • Microbiome

    ASJC Scopus subject areas

    • Gastroenterology

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