Understanding Adherence to Daily and Intermittent Regimens of Oral HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in Kenya

Peter Mwangi Mugo, Eduard J. Sanders, Gaudensia Mutua, Elisabeth van der Elst, Omu Anzala, Burc Barin, David Bangsberg, Frances H. Priddy, Jessica E. Haberer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A qualitative assessment of Kenyan men who have sex with men taking daily and intermittent oral HIV pre-exposure prophylaxis (PrEP) found stigma, sex work, mobility, and alcohol impacted adherence. We analyzed quantitative data from the same cohort to explore different definitions of intermittent adherence. Volunteers were randomized to daily emtricitabine/tenofovir or placebo, or intermittent (prescription: Mondays/Fridays/after sex, maximum 1 dose/day) emtricitabine/tenofovir or placebo (2:1:2:1), and followed for 4 months. By electronic monitoring, median adherence for daily dosing was 80 %. Median adherence for intermittent dosing was 71 % per a “relaxed” definition (accounting for off-prescription dosing) and 40 % per a “strict” definition (limited to the prescription). Factors associated with lower adherence included travel, transactional sex, and longer follow-up; higher adherence was associated with daily dosing and an income. The definition of intermittent dosing strongly affects interpretation of adherence. These findings suggest interventions should address challenges of mobility, sex work, and long-term PrEP.

Original languageEnglish (US)
Pages (from-to)794-801
Number of pages8
JournalAIDS and Behavior
Volume19
Issue number5
DOIs
StatePublished - May 1 2015
Externally publishedYes

Fingerprint

Tenofovir
Kenya
Sex Work
Prescriptions
HIV
Placebos
Volunteers
Alcohols
Pre-Exposure Prophylaxis
Emtricitabine

Keywords

  • HIV
  • Intermittent PrEP adherence
  • Men who have sex with men
  • Pre-exposure prophylaxis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

Cite this

Understanding Adherence to Daily and Intermittent Regimens of Oral HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in Kenya. / Mugo, Peter Mwangi; Sanders, Eduard J.; Mutua, Gaudensia; van der Elst, Elisabeth; Anzala, Omu; Barin, Burc; Bangsberg, David; Priddy, Frances H.; Haberer, Jessica E.

In: AIDS and Behavior, Vol. 19, No. 5, 01.05.2015, p. 794-801.

Research output: Contribution to journalArticle

Mugo, Peter Mwangi ; Sanders, Eduard J. ; Mutua, Gaudensia ; van der Elst, Elisabeth ; Anzala, Omu ; Barin, Burc ; Bangsberg, David ; Priddy, Frances H. ; Haberer, Jessica E. / Understanding Adherence to Daily and Intermittent Regimens of Oral HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in Kenya. In: AIDS and Behavior. 2015 ; Vol. 19, No. 5. pp. 794-801.
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