Underlying mechanisms of tinnitus: Review and clinical implications

James A. Henry, Larry E. Roberts, Donald M. Caspary, Sarah M. Theodoroff, Richard J. Salvi

Research output: Contribution to journalReview article

68 Scopus citations

Abstract

Background: The study of tinnitus mechanisms has increased tenfold in the last decade. The common denominator for all of these studies is the goal of elucidating the underlying neural mechanisms of tinnitus with the ultimate purpose of finding a cure. While these basic science findings may not be immediately applicable to the clinician who works directly with patients to assist them in managing their reactions to tinnitus, a clear understanding of these findings is needed to develop the most effective procedures for alleviating tinnitus. Purpose: The goal of this review is to provide audiologists and other health-care professionals with a basic understanding of the neurophysiological changes in the auditory system likely to be responsible for tinnitus. Results: It is increasingly clear that tinnitus is a pathology involving neuroplastic changes in central auditory structures that take place when the brain is deprived of its normal input by pathology in the cochlea. Cochlear pathology is not always expressed in the audiogram but may be detected by more sensitive measures. Neural changes can occur at the level of synapses between inner hair cells and the auditory nerve and within multiple levels of the central auditory pathway. Long-term maintenance of tinnitus is likely a function of a complex network of structures involving central auditory and nonauditory systems. Conclusions: Patients often have expectations that a treatment exists to cure their tinnitus. They should be made aware that research is increasing to discover such a cure and that their reactions to tinnitus can be mitigated through the use of evidence-based behavioral interventions.

Original languageEnglish (US)
Pages (from-to)5-22
Number of pages18
JournalJournal of the American Academy of Audiology
Volume25
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • Auditory cortex
  • Cochlear nucleus
  • Hyperacusis
  • Spontaneous activity
  • Tinnitus
  • Tonotopy

ASJC Scopus subject areas

  • Speech and Hearing

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