Ultrasound imaging of atherosclerotic plaques

Chad L. Carr, Jonathan Lindner

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The development of techniques for imaging the molecular mediators of atherosclerosis is an area of great interest. The ability to image vascular phenotype will create new opportunities for assessing patient risk for aggressive disease at a very early stage and for choosing appropriate treatment strategies in late stages of disease. Ultrasound will undoubtedly play an important role in molecular imaging because of its practicality as a screening test and because intravascular imaging approaches are already widely used as an adjunct to angiographic procedures. This review focuses on the biophysical principles for the diverse set of tools used to evaluate atherosclerosis. General strategies for imaging vascular phenotype include: 1) assessment of histomorphometry by radiofrequency analysis of high-frequency ultrasound; 2) assessment of plaque content by vascular elastic properties; 3) detection of remodeling of the vasa vasorum by contrast ultrasound; and 4) imaging endothelial molecular phenotype with targeted ultrasound contrast agents.

    Original languageEnglish (US)
    Pages (from-to)24-32
    Number of pages9
    JournalCurrent Cardiovascular Imaging Reports
    Volume2
    Issue number1
    DOIs
    StatePublished - 2009

    Fingerprint

    Molecular Imaging
    Atherosclerotic Plaques
    Blood Vessels
    Ultrasonography
    Phenotype
    Atherosclerosis
    Vasa Vasorum
    Contrast Media
    Therapeutics

    ASJC Scopus subject areas

    • Cell Biology
    • Histology
    • Applied Microbiology and Biotechnology

    Cite this

    Ultrasound imaging of atherosclerotic plaques. / Carr, Chad L.; Lindner, Jonathan.

    In: Current Cardiovascular Imaging Reports, Vol. 2, No. 1, 2009, p. 24-32.

    Research output: Contribution to journalArticle

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