Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?

Andrew Phelps, Raga Ramachandran, Jesse Courtier, Emily Perito, Philip Rosenthal, John D. MacKenzie

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective The objective was to identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation. Methods We performed an institutional-review-board-approved prospective study of liver SWS in 41 children undergoing liver biopsy. Results In patients without inflammation, SWS was higher when fibrosis was present compared to when fibrosis was not present (average SWS 1.8 vs. 1.4 m/s, respectively, P=.02). A SWS cutoff of 1.7 m/s had 100% positive predictive value and 24% negative predictive value for detecting fibrosis or inflammation. Conclusion Point shear wave elastography is an insufficient stand-alone screening tool for liver fibrosis and inflammation in a heterogeneous patient population.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalClinical Imaging
Volume41
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • ARFI
  • Elastography
  • Shear wave speed
  • pSWE

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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