Ulcer disease, metabolic alkalosis and hyperparathyroidism: A mechanism of interrelationship?

E. L. Kaplan, G. W. Peskin, Clifford Deveney, L. Way, B. Jaffe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In both normal volunteers and in patients with primary hyperparathyroidism, the induction of a metabolic alkalosis by infusion of sodium bicarbonate results in a decrease in serum calcium ion and in an increase of circulating parathyroid hormone concentrations. Bicarbonate infusion may serve in man as a new provocative test for release of parathyroid hormone. Furthermore, it is speculated that the metabolic alkalosis which is found at times in patients with the Zollinger Ellison syndrome and severe peptic ulcer disease may result in parathyroid gland stimulation.

Original languageEnglish (US)
Pages (from-to)549-557
Number of pages9
JournalAnnals of Surgery
Volume180
Issue number4
StatePublished - 1974
Externally publishedYes

Fingerprint

Alkalosis
Hyperparathyroidism
Metabolic Diseases
Parathyroid Hormone
Ulcer
Zollinger-Ellison Syndrome
Sodium Bicarbonate
Parathyroid Glands
Primary Hyperparathyroidism
Bicarbonates
Peptic Ulcer
Healthy Volunteers
Ions
Calcium
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Ulcer disease, metabolic alkalosis and hyperparathyroidism : A mechanism of interrelationship? / Kaplan, E. L.; Peskin, G. W.; Deveney, Clifford; Way, L.; Jaffe, B.

In: Annals of Surgery, Vol. 180, No. 4, 1974, p. 549-557.

Research output: Contribution to journalArticle

Kaplan, EL, Peskin, GW, Deveney, C, Way, L & Jaffe, B 1974, 'Ulcer disease, metabolic alkalosis and hyperparathyroidism: A mechanism of interrelationship?', Annals of Surgery, vol. 180, no. 4, pp. 549-557.
Kaplan, E. L. ; Peskin, G. W. ; Deveney, Clifford ; Way, L. ; Jaffe, B. / Ulcer disease, metabolic alkalosis and hyperparathyroidism : A mechanism of interrelationship?. In: Annals of Surgery. 1974 ; Vol. 180, No. 4. pp. 549-557.
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