Two years postconversion from a prograf-based regimen to a once-daily tacrolimus extended-release formulation in stable kidney transplant recipients

Rita Alloway, Steven Steinberg, Kassem Khalil, Sita Gourishankar, Joshua Miller, Douglas Norman, Sundaram Hariharan, John Pirsch, Arthur Matas, Jeffrey Zaltzman, Kathleen Wisemandle, William Fitzsimmons, M. Roy First

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69 Scopus citations

Abstract

Tacrolimus extended-release (XL) is a once-daily formulation recently developed to reduce the frequency of dosing for patients currently using the twice-a-day formulation of tacrolimus (TAC). As reported previously, 67 kidney transplant recipients were safely converted (1:1 mg basis, total daily dose) from TAC twice-a-day to XL once-daily in the morning and were maintained on an am dosing regimen of XL using the same therapeutic monitoring and patient care techniques currently employed with TAC. The 2-year postconversion patient (100%) and graft (98.5%) survival, incidence of biopsy-confirmed acute rejection (6.0%), incidence of multiple rejections (1.5%), and safety profile (posttransplant diabetes, hyperlipidemia, hypertension, infections, renal dysfunction, hepatic dysfunction, and malignancies) were consistent with or more favorable than those previously reported for TAC twice-a-day.

Original languageEnglish (US)
Pages (from-to)1648-1651
Number of pages4
JournalTransplantation
Volume83
Issue number12
DOIs
StatePublished - Jun 1 2007

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Keywords

  • Conversion
  • Extended-release
  • Kidney transplant recipients
  • Tacrolimus twice-a-day
  • Two-year safety
  • XL once-daily

ASJC Scopus subject areas

  • Transplantation

Cite this

Alloway, R., Steinberg, S., Khalil, K., Gourishankar, S., Miller, J., Norman, D., Hariharan, S., Pirsch, J., Matas, A., Zaltzman, J., Wisemandle, K., Fitzsimmons, W., & First, M. R. (2007). Two years postconversion from a prograf-based regimen to a once-daily tacrolimus extended-release formulation in stable kidney transplant recipients. Transplantation, 83(12), 1648-1651. https://doi.org/10.1097/01.tp.0000264056.20105.b4