Two independently regulated secretory pathways in mast cells

J. Kirillova, P. Thomas, W. Almers

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We review here evidence that mast cells independently secrete large and small vesicles. Release of small vesicles is triggered by Ca2+. Combining capacitance measurements and flash photolysis of caged Ca2+, we demonstrate Ca-triggered exocytosis that is kinetically identical to the release of dense-core peptidergic vesicles from pituitary melanotrophs. It is suggested that the secretory pathway used for hormone secretion in neuroendocrine cells is also active in mast cells and eosinophils. The nature of the mediator thus secreted is unknown.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalJournal of Physiology - Paris
Volume87
Issue number3
DOIs
StatePublished - 1993

Keywords

  • Ca
  • eosinophils
  • hormone secretion
  • secretory pathways

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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