Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Anders Fridberger, Tianying Ren, Ruikang Wang, Steven L. Jacques, Alfred L. Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 - 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the surgery needed to access the guinea pig apex in the axial direction by introducing a miniature mirror inside the bulla. The method and preliminary data are discussed in this article.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics XI
EditorsHyun Wook Kang, Justus F. Ilgner, Melissa C. Skala, Laura Marcu, Haishan Zeng, Mark W. Dewhirst, Kenton W. Gregory, Andreas Mandelis, Bernard Choi, Brian Jet-Fei Wong, Claus-Peter Richter, Guillermo J. Tearney, Alfred Nuttal, Nikiforos Kollias
PublisherSPIE
ISBN (Electronic)9781628413939
DOIs
StatePublished - Jan 1 2015
EventPhotonic Therapeutics and Diagnostics XI - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9303
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics XI
CountryUnited States
CitySan Francisco
Period2/7/152/8/15

Keywords

  • Biomedical optical imaging
  • Cochlear vibration
  • Optical coherence tomography
  • Optical interferometry
  • Phase-sensitive Fourier domain OCT
  • Speech

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography'. Together they form a unique fingerprint.

  • Cite this

    Ramamoorthy, S., Zhang, Y., Petrie, T., Fridberger, A., Ren, T., Wang, R., Jacques, S. L., & Nuttall, A. L. (2015). Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography. In H. W. Kang, J. F. Ilgner, M. C. Skala, L. Marcu, H. Zeng, M. W. Dewhirst, K. W. Gregory, A. Mandelis, B. Choi, B. J-F. Wong, C-P. Richter, G. J. Tearney, A. Nuttal, & N. Kollias (Eds.), Photonic Therapeutics and Diagnostics XI [93031L] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9303). SPIE. https://doi.org/10.1117/12.2079673