Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Anders Fridberger, Tianying Ren, Ruikang Wang, Steven Jacques, Alfred Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 - 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the surgery needed to access the guinea pig apex in the axial direction by introducing a miniature mirror inside the bulla. The method and preliminary data are discussed in this article.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics XI
PublisherSPIE
Volume9303
ISBN (Print)9781628413939
DOIs
StatePublished - 2015
EventPhotonic Therapeutics and Diagnostics XI - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Other

OtherPhotonic Therapeutics and Diagnostics XI
CountryUnited States
CitySan Francisco
Period2/7/152/8/15

Fingerprint

guinea pigs
Organ of Corti
Optical tomography
Optical Coherence Tomography
Vibration
organs
Surgery
Capsules
Bone
Guinea Pigs
Mirrors
apexes
Hydrodynamics
tomography
vibration
Cochlea
capsules
Ear
cochlea
Blister

Keywords

  • Biomedical optical imaging
  • Cochlear vibration
  • Optical coherence tomography
  • Optical interferometry
  • Phase-sensitive Fourier domain OCT
  • Speech

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ramamoorthy, S., Zhang, Y., Petrie, T., Fridberger, A., Ren, T., Wang, R., ... Nuttall, A. (2015). Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography. In Photonic Therapeutics and Diagnostics XI (Vol. 9303). [93031L] SPIE. https://doi.org/10.1117/12.2079673

Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography. / Ramamoorthy, Sripriya; Zhang, Yuan; Petrie, Tracy; Fridberger, Anders; Ren, Tianying; Wang, Ruikang; Jacques, Steven; Nuttall, Alfred.

Photonic Therapeutics and Diagnostics XI. Vol. 9303 SPIE, 2015. 93031L.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ramamoorthy, S, Zhang, Y, Petrie, T, Fridberger, A, Ren, T, Wang, R, Jacques, S & Nuttall, A 2015, Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography. in Photonic Therapeutics and Diagnostics XI. vol. 9303, 93031L, SPIE, Photonic Therapeutics and Diagnostics XI, San Francisco, United States, 2/7/15. https://doi.org/10.1117/12.2079673
Ramamoorthy S, Zhang Y, Petrie T, Fridberger A, Ren T, Wang R et al. Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography. In Photonic Therapeutics and Diagnostics XI. Vol. 9303. SPIE. 2015. 93031L https://doi.org/10.1117/12.2079673
Ramamoorthy, Sripriya ; Zhang, Yuan ; Petrie, Tracy ; Fridberger, Anders ; Ren, Tianying ; Wang, Ruikang ; Jacques, Steven ; Nuttall, Alfred. / Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography. Photonic Therapeutics and Diagnostics XI. Vol. 9303 SPIE, 2015.
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