Twin valve caval stent for functional replacement of incompetent tricuspid valve: A feasibility animal study

Jan Sochman, Jan H. Peregrin, Dusan Pavcnik, Barry Uchida, Hans A. Timmermans, Masashi Shimohira, Young Ho Choi, Frederick Keller, Josef Rosch

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To evaluate feasibility of a twin valve caval stent (TVCS) for functional replacement of an incompetent tricuspid valve (TV) in an acute animal study. Methods: One swine and three sheep were used in the study. TVCS placement was tested in a swine with a normal TV. TVCS function was tested in three sheep with TV regurgitation created by papillary muscle avulsion. Cardiac angiograms and pressure measurements were used to evaluate TVCS function. Two sheep were studied after fluid overload. Results: TVCS was percutaneously placed properly at the central portions of the superior vena cava (SVC) and inferior vena cava (IVC) in the swine. Papillary muscle avulsion in three sheep caused significant tricuspid regurgitation with massive reflux into the right atrium (RA) and partial reflux into the SVC and IVC. TVCS placement eliminated reflux into the SVC and IVC. After fluid overload, there was enlargement of the right ventricle and RA and significant increase in right ventricle, RA, SVC, and IVC pressures, but no reflux into the IVC and SVC. Conclusion: The results of this feasibility study justify detailed evaluation of TVCS insertion for functional chronic replacement of incompetent TV.

Original languageEnglish (US)
Pages (from-to)174-179
Number of pages6
JournalCardioVascular and Interventional Radiology
Volume34
Issue number1
DOIs
StatePublished - Feb 2011

Fingerprint

Venae Cavae
Tricuspid Valve
Feasibility Studies
Stents
Superior Vena Cava
Inferior Vena Cava
Sheep
Heart Atria
Tricuspid Valve Insufficiency
Swine
Papillary Muscles
Heart Ventricles
Pressure
Angiography

Keywords

  • Animal experiment
  • Caval valve stent
  • Functional tricuspid replacement
  • Tricuspid regurgitation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Twin valve caval stent for functional replacement of incompetent tricuspid valve : A feasibility animal study. / Sochman, Jan; Peregrin, Jan H.; Pavcnik, Dusan; Uchida, Barry; Timmermans, Hans A.; Shimohira, Masashi; Choi, Young Ho; Keller, Frederick; Rosch, Josef.

In: CardioVascular and Interventional Radiology, Vol. 34, No. 1, 02.2011, p. 174-179.

Research output: Contribution to journalArticle

Sochman, Jan ; Peregrin, Jan H. ; Pavcnik, Dusan ; Uchida, Barry ; Timmermans, Hans A. ; Shimohira, Masashi ; Choi, Young Ho ; Keller, Frederick ; Rosch, Josef. / Twin valve caval stent for functional replacement of incompetent tricuspid valve : A feasibility animal study. In: CardioVascular and Interventional Radiology. 2011 ; Vol. 34, No. 1. pp. 174-179.
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