Tumor necrosis factor-α inhibitor-induced psoriasis: Systematic review of clinical features, histopathological findings, and management experience

Gabrielle Brown, Eva Wang, Argentina Leon, Monica Huynh, Mackenzie Wehner, Rebecca Matro, Eleni Linos, Wilson Liao, Anna Haemel

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Background Tumor necrosis factor-α (TNF-α) inhibitors have been reported to induce new-onset psoriasis. Objective To better define the demographic, clinical features, and treatment approach of TNF-α inhibitor-induced psoriasis. Methods Systematic review of published cases of TNF-α inhibitor-induced psoriasis. Results We identified 88 articles with 216 cases of new-onset TNF-α inhibitor-induced psoriasis. The mean age at psoriasis onset was 38.5 years. The most common underlying diseases were Crohn disease (40.7%) and rheumatoid arthritis (37.0%). Patients underwent TNF-α therapy for an average of 14.0 months before psoriasis onset with 69.9% of patients experiencing onset within the first year. The majority of patients received skin-directed therapy, though patients who discontinued TNF therapy had the greatest resolution of symptoms (47.7%) compared with those who switched to a different TNF agent (36.7%) or continued therapy (32.9%). Limitations Retrospective review that relies on case reports and series. Conclusion While TNF-α inhibitor cessation may result in resolution of induced psoriasis, lesions may persist. Decisions regarding treatment should be weighed against the treatability of TNF-α inhibitor-induced psoriasis, the severity of the background rheumatologic or gastrointestinal disease, and possible loss of efficacy with cessation followed by retreatment. Skin-directed therapy is a reasonable initial strategy except in severe cases.

Original languageEnglish (US)
Pages (from-to)334-341
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume76
Issue number2
DOIs
StatePublished - Feb 2017
Externally publishedYes

Keywords

  • adalimumab
  • adverse event
  • certolizumab
  • etanercept
  • golimumab
  • infliximab
  • medication side effect
  • psoriasis
  • tumor necrosis factor-α inhibitor
  • tumor necrosis factor-α-induced psoriasis

ASJC Scopus subject areas

  • Dermatology

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