Tumor microenvironment complexity: Emerging roles in cancer therapy

Melody A. Swartz, Noriho Iida, Edward W. Roberts, Sabina Sangaletti, Melissa Wong, Fiona E. Yull, Lisa Coussens, Yves A. DeClerck

Research output: Contribution to journalArticle

269 Citations (Scopus)

Abstract

The tumor microenvironment (TME) consists of cells, soluble factors, signaling molecules, extracellular matrix, and mechanical cues that can promote neoplastic transformation, support tumor growth and invasion, protect the tumor from host immunity, foster therapeutic resistance, and provide niches for dormant metastases to thrive. An American Association for Cancer Research (AACR) special conference held on November 3-6, 2011, addressed five emerging concepts in our understanding of the TME: its dynamic evolution, how it is educated by tumor cells, pathways of communication between stromal and tumor cells, immunomodulatory roles of the lymphatic system, and contribution of the intestinal microbiota. These discussions raised critical questions on how to include the analysis of the TME in personalized cancer diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)2473-2480
Number of pages8
JournalCancer Research
Volume72
Issue number10
DOIs
StatePublished - May 15 2012

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Tumor Microenvironment
Neoplasms
Therapeutics
Lymphatic System
Stromal Cells
Cell Communication
Cues
Extracellular Matrix
Immunity
Neoplasm Metastasis
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Swartz, M. A., Iida, N., Roberts, E. W., Sangaletti, S., Wong, M., Yull, F. E., ... DeClerck, Y. A. (2012). Tumor microenvironment complexity: Emerging roles in cancer therapy. Cancer Research, 72(10), 2473-2480. https://doi.org/10.1158/0008-5472.CAN-12-0122

Tumor microenvironment complexity : Emerging roles in cancer therapy. / Swartz, Melody A.; Iida, Noriho; Roberts, Edward W.; Sangaletti, Sabina; Wong, Melissa; Yull, Fiona E.; Coussens, Lisa; DeClerck, Yves A.

In: Cancer Research, Vol. 72, No. 10, 15.05.2012, p. 2473-2480.

Research output: Contribution to journalArticle

Swartz, MA, Iida, N, Roberts, EW, Sangaletti, S, Wong, M, Yull, FE, Coussens, L & DeClerck, YA 2012, 'Tumor microenvironment complexity: Emerging roles in cancer therapy', Cancer Research, vol. 72, no. 10, pp. 2473-2480. https://doi.org/10.1158/0008-5472.CAN-12-0122
Swartz MA, Iida N, Roberts EW, Sangaletti S, Wong M, Yull FE et al. Tumor microenvironment complexity: Emerging roles in cancer therapy. Cancer Research. 2012 May 15;72(10):2473-2480. https://doi.org/10.1158/0008-5472.CAN-12-0122
Swartz, Melody A. ; Iida, Noriho ; Roberts, Edward W. ; Sangaletti, Sabina ; Wong, Melissa ; Yull, Fiona E. ; Coussens, Lisa ; DeClerck, Yves A. / Tumor microenvironment complexity : Emerging roles in cancer therapy. In: Cancer Research. 2012 ; Vol. 72, No. 10. pp. 2473-2480.
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