1. 1. Tumor cells were injected into the left ventricle of infant and adult rabbits and ocular metastases subsequently developed in the majority of animals. 2. 2. The incidence of metastasis to the eye was comparable to the incidence of metastasis in other organs. 3. 3. Ocular metastasis occurred almost exclusively in the iris, ciliary body and anterior choroid. 4. 4. Stained tumor cells injected into the left ventricle were found throughout the capillaries of the entire choroid and less frequently in the iris and ciliary body. 5. 5. The predominance of tumors in the iris, ciliary body and anterior choroid does not appear to result from a relative concentration of arrested tumor cells in that area. 6. 6. These results suggest that in the eye, local environmental factors are important in assuring the development of an arrested tumor cell embolus into a metastasis.
ASJC Scopus subject areas