TY - JOUR
T1 - Tumor metastasis to the eye. Part III. The fate of circulating tumor cells to the eye
AU - Albert, Daniel M.
AU - Zimmermann, Albert W.
AU - Zeidman, Irving
N1 - Funding Information:
The Brown-Pearce and V2 tumor strains were used in infant (two weeks old) and adult New Zealand white rabbits of mixed sex. Tumor cell suspensions were prepared by passing tumor fragments into a balanced salt solution. Most clumps were removed from the suspension by centrifugation. Cell From the Department of Ophthalmology, Hospital of the University of Pennsylvania, Philadelphia General Hospital, the Veterans Administration Hospital, the Children's Hospital of Philadelphia, and the Department of Pathology, University of Pennsylvania School of Medicine. This study was supported by an institutional grant from the American 'Cancer Society (IN-38F), subproject 10, and by United States Public Health Service grant 5-R01-CA02356-12 from the National Cancer Institute. Reprint requests to the Department of Ophthalmology, Hospital of the University of Pennsylvania.
PY - 1967/4
Y1 - 1967/4
N2 - 1. 1. Tumor cells were injected into the left ventricle of infant and adult rabbits and ocular metastases subsequently developed in the majority of animals. 2. 2. The incidence of metastasis to the eye was comparable to the incidence of metastasis in other organs. 3. 3. Ocular metastasis occurred almost exclusively in the iris, ciliary body and anterior choroid. 4. 4. Stained tumor cells injected into the left ventricle were found throughout the capillaries of the entire choroid and less frequently in the iris and ciliary body. 5. 5. The predominance of tumors in the iris, ciliary body and anterior choroid does not appear to result from a relative concentration of arrested tumor cells in that area. 6. 6. These results suggest that in the eye, local environmental factors are important in assuring the development of an arrested tumor cell embolus into a metastasis.
AB - 1. 1. Tumor cells were injected into the left ventricle of infant and adult rabbits and ocular metastases subsequently developed in the majority of animals. 2. 2. The incidence of metastasis to the eye was comparable to the incidence of metastasis in other organs. 3. 3. Ocular metastasis occurred almost exclusively in the iris, ciliary body and anterior choroid. 4. 4. Stained tumor cells injected into the left ventricle were found throughout the capillaries of the entire choroid and less frequently in the iris and ciliary body. 5. 5. The predominance of tumors in the iris, ciliary body and anterior choroid does not appear to result from a relative concentration of arrested tumor cells in that area. 6. 6. These results suggest that in the eye, local environmental factors are important in assuring the development of an arrested tumor cell embolus into a metastasis.
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U2 - 10.1016/0002-9394(67)91299-8
DO - 10.1016/0002-9394(67)91299-8
M3 - Article
C2 - 6023682
AN - SCOPUS:0014077380
SN - 0002-9394
VL - 63
SP - 733
EP - 738
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 4
ER -