T magnetic resonance fingerprinting

Cory R. Wyatt, Thomas M. Barbara, Alexander R. Guimaraes

Research output: Contribution to journalArticle

Abstract

T relaxation imaging is a quantitative imaging technique that has been used to assess cartilage integrity, liver fibrosis, tumors, cardiac infarction, and Alzheimer's disease. T1, T2, and T relaxation time constants have each demonstrated different degrees of sensitivity to several markers of fibrosis and inflammation, allowing for a potential multi-parametric approach to tissue quantification. Traditional magnetic resonance fingerprinting (MRF) has been shown to provide quick, quantitative mapping of T1 and T2 relaxation time constants. In this study, T relaxation is added to the MRF framework using spin lock preparations. An MRF sequence involving an RF-spoiled sequence with TR, flip angle, T, and T2 preparation variation is described. The sequence is then calibrated against conventional T1, T2, and T relaxation mapping techniques in agar phantoms and the abdomens of four healthy volunteers. Strong intraclass correlation coefficients (ICC > 0.9) were found between conventional and MRF sequences in phantoms and also in healthy volunteers (ICC > 0.8). The highest ICC correlation values were seen in T1, followed by T and then T2. In this study, T relaxation has been incorporated into the MRF framework by using spin lock preparations, while still fitting for T1 and T2 relaxation time constants. The acquisition of these parameters within a single breath hold in the abdomen alleviates the issues of movement between breath holds in conventional techniques.

Original languageEnglish (US)
Article numbere4284
JournalNMR in biomedicine
Volume33
Issue number5
DOIs
StatePublished - May 1 2020

Keywords

  • body
  • quantitation
  • relaxometry
  • sampling strategies

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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