Trivalent T cell receptor peptide vaccine for treatment of multiple sclerosis targets predominant V genes widely implicated in autoimmune diseases and allergy

Arthur Vandenbark, Nicole E. Culbertson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The involvement of T cells in the pathogenesis of human autoimmune disease has long been suspected, even though few data are available that directly implicate these T cells. In contrast, antigen-specific CD4+ T cells have clearly been demonstratedto induce autoimmune tissue destruction and clinical disease in experimental animal models. These pathogenic T cells retained the tendency to develop characteristic CDR3 "motifs" specific for target peptides, as well as to utilize common V gene families. This knowledge has led to immune interventions directed at both clonotypic CDR3 determinants present on only the peptide-specific T cells and more broadly represented V gene determinants, typically the CDR1, CDR2, and FW3 loops of the TCR.

Original languageEnglish (US)
Title of host publicationImmune Regulation and Immunotherapy in Autoimmune Disease
PublisherSpringer US
Pages369-408
Number of pages40
ISBN (Print)0387360026, 9780387360027
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Subunit Vaccines
T-Cell Antigen Receptor
Autoimmune Diseases
Multiple Sclerosis
Hypersensitivity
T-Lymphocytes
Genes
Peptide T
CD4 Antigens
Animal Models
Peptides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Trivalent T cell receptor peptide vaccine for treatment of multiple sclerosis targets predominant V genes widely implicated in autoimmune diseases and allergy. / Vandenbark, Arthur; Culbertson, Nicole E.

Immune Regulation and Immunotherapy in Autoimmune Disease. Springer US, 2007. p. 369-408.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vandenbark, Arthur ; Culbertson, Nicole E. / Trivalent T cell receptor peptide vaccine for treatment of multiple sclerosis targets predominant V genes widely implicated in autoimmune diseases and allergy. Immune Regulation and Immunotherapy in Autoimmune Disease. Springer US, 2007. pp. 369-408
@inbook{d9daeee128ec438a84324e079ba0e289,
title = "Trivalent T cell receptor peptide vaccine for treatment of multiple sclerosis targets predominant V genes widely implicated in autoimmune diseases and allergy",
abstract = "The involvement of T cells in the pathogenesis of human autoimmune disease has long been suspected, even though few data are available that directly implicate these T cells. In contrast, antigen-specific CD4+ T cells have clearly been demonstratedto induce autoimmune tissue destruction and clinical disease in experimental animal models. These pathogenic T cells retained the tendency to develop characteristic CDR3 {"}motifs{"} specific for target peptides, as well as to utilize common V gene families. This knowledge has led to immune interventions directed at both clonotypic CDR3 determinants present on only the peptide-specific T cells and more broadly represented V gene determinants, typically the CDR1, CDR2, and FW3 loops of the TCR.",
author = "Arthur Vandenbark and Culbertson, {Nicole E.}",
year = "2007",
doi = "10.1007/978-0-387-36003-4_16",
language = "English (US)",
isbn = "0387360026",
pages = "369--408",
booktitle = "Immune Regulation and Immunotherapy in Autoimmune Disease",
publisher = "Springer US",

}

TY - CHAP

T1 - Trivalent T cell receptor peptide vaccine for treatment of multiple sclerosis targets predominant V genes widely implicated in autoimmune diseases and allergy

AU - Vandenbark, Arthur

AU - Culbertson, Nicole E.

PY - 2007

Y1 - 2007

N2 - The involvement of T cells in the pathogenesis of human autoimmune disease has long been suspected, even though few data are available that directly implicate these T cells. In contrast, antigen-specific CD4+ T cells have clearly been demonstratedto induce autoimmune tissue destruction and clinical disease in experimental animal models. These pathogenic T cells retained the tendency to develop characteristic CDR3 "motifs" specific for target peptides, as well as to utilize common V gene families. This knowledge has led to immune interventions directed at both clonotypic CDR3 determinants present on only the peptide-specific T cells and more broadly represented V gene determinants, typically the CDR1, CDR2, and FW3 loops of the TCR.

AB - The involvement of T cells in the pathogenesis of human autoimmune disease has long been suspected, even though few data are available that directly implicate these T cells. In contrast, antigen-specific CD4+ T cells have clearly been demonstratedto induce autoimmune tissue destruction and clinical disease in experimental animal models. These pathogenic T cells retained the tendency to develop characteristic CDR3 "motifs" specific for target peptides, as well as to utilize common V gene families. This knowledge has led to immune interventions directed at both clonotypic CDR3 determinants present on only the peptide-specific T cells and more broadly represented V gene determinants, typically the CDR1, CDR2, and FW3 loops of the TCR.

UR - http://www.scopus.com/inward/record.url?scp=37149019020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37149019020&partnerID=8YFLogxK

U2 - 10.1007/978-0-387-36003-4_16

DO - 10.1007/978-0-387-36003-4_16

M3 - Chapter

SN - 0387360026

SN - 9780387360027

SP - 369

EP - 408

BT - Immune Regulation and Immunotherapy in Autoimmune Disease

PB - Springer US

ER -