TY - CHAP
T1 - Trivalent T cell receptor peptide vaccine for treatment of multiple sclerosis targets predominant V genes widely implicated in autoimmune diseases and allergy
AU - Vandenbark, Arthur A.
AU - Culbertson, Nicole E.
PY - 2007
Y1 - 2007
N2 - The involvement of T cells in the pathogenesis of human autoimmune disease has long been suspected, even though few data are available that directly implicate these T cells. In contrast, antigen-specific CD4+ T cells have clearly been demonstratedto induce autoimmune tissue destruction and clinical disease in experimental animal models. These pathogenic T cells retained the tendency to develop characteristic CDR3 "motifs" specific for target peptides, as well as to utilize common V gene families. This knowledge has led to immune interventions directed at both clonotypic CDR3 determinants present on only the peptide-specific T cells and more broadly represented V gene determinants, typically the CDR1, CDR2, and FW3 loops of the TCR.
AB - The involvement of T cells in the pathogenesis of human autoimmune disease has long been suspected, even though few data are available that directly implicate these T cells. In contrast, antigen-specific CD4+ T cells have clearly been demonstratedto induce autoimmune tissue destruction and clinical disease in experimental animal models. These pathogenic T cells retained the tendency to develop characteristic CDR3 "motifs" specific for target peptides, as well as to utilize common V gene families. This knowledge has led to immune interventions directed at both clonotypic CDR3 determinants present on only the peptide-specific T cells and more broadly represented V gene determinants, typically the CDR1, CDR2, and FW3 loops of the TCR.
UR - http://www.scopus.com/inward/record.url?scp=37149019020&partnerID=8YFLogxK
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U2 - 10.1007/978-0-387-36003-4_16
DO - 10.1007/978-0-387-36003-4_16
M3 - Chapter
AN - SCOPUS:37149019020
SN - 0387360026
SN - 9780387360027
SP - 369
EP - 408
BT - Immune Regulation and Immunotherapy in Autoimmune Disease
PB - Springer US
ER -