TY - JOUR
T1 - Trial-to-trial noise cancellation of cortical field potentials in awake macaques by autoregression model with exogenous input (ARX)
AU - Wang, Zheng
AU - Roe, Anna W.
N1 - Funding Information:
This work was funded by NIH EY11744 (AWR), DA023002 (AWR), Vanderbilt Vision Research Center, and Vanderbilt University Center for Integrative & Cognitive Neuroscience . We thank Robert Friedman for providing the NI LabVIEW support, Roger Williams and Bruce Williams for excellent mechanic support, and Lisa Chu for awake primate training. We acknowledge two anonymous reviewers for their invaluable criticism and comments that improved the manuscript.
PY - 2011/1/15
Y1 - 2011/1/15
N2 - Gamma band synchronization has drawn increasing interest with respect to its potential role in neuronal encoding strategy and behavior in awake, behaving animals. However, contamination of these recordings by power line noise can confound the analysis and interpretation of cortical local field potential (LFP). Existing denoising methods are plagued by inadequate noise reduction, inaccuracies, and even introduction of new noise components. To carefully and more completely remove such contamination, we propose an automatic method based on the concept of adaptive noise cancellation that utilizes the correlative features of common noise sources, and implement with AutoRegressive model with eXogenous Input (ARX). We apply this technique to both simulated data and LFPs recorded in the primary visual cortex of awake macaque monkeys. The analyses here demonstrate a greater degree of accurate noise removal than conventional notch filters. Our method leaves desired signal intact and does not introduce artificial noise components. Application of this method to awake monkey V1 recordings reveals a significant power increase in the gamma range evoked by visual stimulation. Our findings suggest that the ARX denoising procedure will be an important pre-processing step in the analysis of large volumes of cortical LFP data as well as high frequency (gamma-band related) electroencephalography/magnetoencephalography (EEG/MEG) applications, one which will help to convincingly dissociate this notorious artifact from gamma-band activity.
AB - Gamma band synchronization has drawn increasing interest with respect to its potential role in neuronal encoding strategy and behavior in awake, behaving animals. However, contamination of these recordings by power line noise can confound the analysis and interpretation of cortical local field potential (LFP). Existing denoising methods are plagued by inadequate noise reduction, inaccuracies, and even introduction of new noise components. To carefully and more completely remove such contamination, we propose an automatic method based on the concept of adaptive noise cancellation that utilizes the correlative features of common noise sources, and implement with AutoRegressive model with eXogenous Input (ARX). We apply this technique to both simulated data and LFPs recorded in the primary visual cortex of awake macaque monkeys. The analyses here demonstrate a greater degree of accurate noise removal than conventional notch filters. Our method leaves desired signal intact and does not introduce artificial noise components. Application of this method to awake monkey V1 recordings reveals a significant power increase in the gamma range evoked by visual stimulation. Our findings suggest that the ARX denoising procedure will be an important pre-processing step in the analysis of large volumes of cortical LFP data as well as high frequency (gamma-band related) electroencephalography/magnetoencephalography (EEG/MEG) applications, one which will help to convincingly dissociate this notorious artifact from gamma-band activity.
KW - Adaptive noise cancellation (ANC)
KW - Autoregression model with exogenous input (ARX)
KW - Awake macaque
KW - Gamma band
KW - Local field potential
KW - Wavelet transform
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U2 - 10.1016/j.jneumeth.2010.10.029
DO - 10.1016/j.jneumeth.2010.10.029
M3 - Article
C2 - 21074560
AN - SCOPUS:78650510465
SN - 0165-0270
VL - 194
SP - 266
EP - 273
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
IS - 2
ER -